Ranitidine-hydrochloride _Histamine Receptor Antagonist - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERanitidine hydrochlorideCat. No.: HY-B0281ACAS No.: 66357-59-3分式: CHClNOS分量: 350.86作靶點: Histamine Receptor作通路: GPCR/G Protein; Immunology/Inflammation; NeuronalSignaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-

2、20C 1 month溶解性數(shù)據體外實驗 H2O : 50 mg/mL (142.51 mM)DMSO : 50 mg/mL (142.51 mM; Need ultrasonic)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.8501 mL 14.2507 mL 28.5014 mL5 mM 0.5700 mL 2.8501 mL 5.7003 mL10 mM 0.2850 mL 1.4251 mL 2.8501 mL請根據產品在不同溶劑中的溶解度，選擇

3、合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗請根據您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結果的可靠性，體內實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.13 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in sa

4、line)1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (7.13 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.13 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Ranitidine hydrochloride是組胺H2-受體拮抗劑，IC50為3.3uM。REFERENCES1. Herling, A.W., et al., Inhibition

5、of 14C-aminopyrine accumulation in isolated rabbit gastric glands by the H2-receptor antagonist HOE 760(TZU-0460). Agents Actions, 1987. 20(1-2): p. 35-9.2. Leucuta, A., et al., A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug MetabolDrug Interact, 2004. 20(4): p. 273-81.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 02