BRAF-inhibitor _Raf 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBRAF inhibitorCat. No.: HY-10247CAS No.: 918505-61-0分式: CHFNOS分量: 456.47作靶點(diǎn): Raf作通路: MAPK/ERK Pathway儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 50 mg/mL (109.54 mM; Need ultrasonic)Mas

2、s Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.1907 mL 10.9536 mL 21.9072 mL5 mM 0.4381 mL 2.1907 mL 4.3814 mL10 mM 0.2191 mL 1.0954 mL 2.1907 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百

3、分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.48 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.48 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.48 mM); Clear solutio

4、n1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 BRAF inhibitor種 B-Raf 抑制劑，詳細(xì)信息請(qǐng)參考專利獻(xiàn) WO2012006552A1 中的化合物 P-0850。IC50 & Target B-RafREFERENCES1. Prahbha N. Ibrahim, et al. Pyrrolo2,3-b pyridine derivatives as protein kinase inhibitors. WO2007002325A1.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 0