Dabigatran-etexilate-mesylate-BIBR-1048MS-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDabigatran etexilate mesylateCat. No.: HY-10274ACAS No.: 872728-81-9Synonyms: BIBR 1048MS; Dabigatran etexilate methanesulfonate分式: CHNOS分量: 723.84作靶點: Thrombin作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn s

2、olvent -80C 6 months-20C 1 month溶解性數據體外實驗 DMSO : 50 mg/mL (69.08 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.3815 mL 6.9076 mL 13.8152 mL5 mM 0.2763 mL 1.3815 mL 2.7630 mL10 mM 0.1382 mL 0.6908 mL 1.3815 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗請根據您的實驗動物和給藥式選擇適當

3、的溶解案，配制前請先配制澄清的儲備液，再依次添加助溶劑(為保證實驗結果的可靠性，體內實驗的作液，建議您現現配，當天使；澄清的儲備液可以根據儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (3.45 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (3.45 mM); Clear sol

4、ution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (3.45 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Dabigatran etexilate mesylate (BIBR 1048MS)服活性的dabigatran前藥。Dabigatran 可逆的直接凝酶抑制劑（DTI），Ki為4.5 nM。戶使本產品發(fā)表的科研獻 Biochem Pharmacol. 2016 Nov 1;11

5、9:76-84. J Chromatogr Sci. 2016 Jul 29;54(9):1648-1651.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Wienen W, Stassen JM, Priepke H, In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and itsorally activeprodrug, dabigatran etexil

6、ate. Thromb Haemost. 2007 Jul;98(1):155-62.2. Kansal AR, Sorensen SV, Gani R, Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UKpatients withatrial fibrillation. Heart. 2012 Apr;98(7):573-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-8