INH14 _IKK 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEINH14Cat. No.: HY-114454CAS No.: 200134-22-1分式: CHNO分量: 240.3作靶點(diǎn): IKK作通路: NF-B儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 125 mg/mL (520.18 mM)H2O : 40% PEG300 5% Tween-80 45% salineSol

2、ubility: 2.08 mg/mL (8.66 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (8.66 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 INH14是IKK/IKK 的抑制劑，IC50 值分別為 8.97 和 3.59 M。INH14 抑制 IKK/ 依賴性 TLR 炎癥反應(yīng)。抑制 TAK1/TAB1 的下游和 NF-kB 信號(hào)通路。具

3、有抗炎和抗癌作 1。IC50 & Target IKK IKK3.59 M (IC50) 8.97 M (IC50)體內(nèi)研究 INH14 (5 g/g, i.p. for 2 hours) reduces lipopeptide-induced inflammation in mice 1.Animal Model: 8-week old, male, pathogen-free C57BL/6J mice 1Dosage: 5 g/g, one hour before Pam2CSK4 injectionAdministration: I.P. for 2 hoursResult: Decr

4、eased TNF production in mice.REFERENCES1. Drexel M, et al. INH14, a Small-Molecule Urea Derivative, Inhibits the IKK/-Dependent TLR Inflammatory Response. Chembiochem.2019 Mar 1;20(5):710-717.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021-5