Zalcitabine-ddC-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEZalcitabineCat. No.: HY-17392CAS No.: 7481-89-2Synonyms: ddC; Dideoxycytidine; 2,3-Dideoxycytidine分式: CHNO分量: 211.22作靶點: HIV; Reverse Transcriptase作通路: Anti-infection儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C

2、 1 month溶解性數據體外實驗 DMSO : 16.67 mg/mL (78.92 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 4.7344 mL 23.6720 mL 47.3440 mL5 mM 0.9469 mL 4.7344 mL 9.4688 mL10 mM 0.4734 mL 2.3672 mL 4.7344 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗請根據您的實驗動物和給藥式選擇適當的溶解案，配制前

3、請先配制澄清的儲備液，再依次添加助溶劑(為保證實驗結果的可靠性，體內實驗的作液，建議您現現配，當天使；澄清的儲備液可以根據儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (11.84 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (11.84 mM); Clear solution3

4、. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (11.84 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Zalcitabine有效的核苷類似物逆轉錄酶抑制劑，于治療HIV感染。IC50 & Target Target: HIV體外研究 Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated t

5、o the active metabolite 2,3-dideoxycytidine 5-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeuticconcentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminatingelongation of the proviral DNA chain 1. Zalcitabine exhibits th

6、e inhibition effect on the cellular uptake of3H-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. Furthermore, the cellular uptake of zalcitabineincreased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells 2.REFERENCES1. Adkins JC, et al. Zalcitabine. An update of its pharmacody

7、namic and pharmacokinetic properties and clinical efficacy in the managementof HIV infection.Drugs. 1997 Jun;53(6):1054-802. Jin MJ, et al. Interaction of zalcitabine with human organic anion transporter 1. Pharmazie. 2006 May;61(5):491-2.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use