多組分反應(yīng)和串聯(lián)反應(yīng)課件

1、第五章 Multi-Component ReactionsMulticomponents reactions (MCRs) are those reactions in which three or more reactants come together in a single reaction vessel to form a new product which contains portions of all the componentsMCRA+B+C.PConvergencyComplexityProductivitySelectivityAtom economyDiversity一

2、、多組分反應(yīng)的歷史Ivar Karl Ugi (1930-2005), the inventor of the most significant isocyanide based MCRs.二、多組分反應(yīng)涉及的反應(yīng)機(jī)理1.離子機(jī)理異腈參與的多組分反應(yīng)大多為離子機(jī)理。Angew. Chem. Int. Ed. 1998, 37, 22342.自由基機(jī)理Angew. Chem. Int. Ed. 2003, 42, 34903.周環(huán)反應(yīng)機(jī)理Tetrahedron Lett. 1998, 29, 58554.混合機(jī)理自由基和負(fù)離子組合Angew. Chem. Int. Ed. 1998, 37, 1

3、52三、金屬催化的多組分反應(yīng)四、多組分反應(yīng)展望Hardly a field in organic chemistry has evolved faster over only a couple of years than MCRs. However, the very large MCR space of 1020 is only explored marginally.Future research in the area of MCRs will include the discovery and design of novel MCRs, combinations of MCRs and

4、 traditional reactions, experimental improvements in solid-and liquid-phase, enantio-and diastereo-selective variations, and more and more applications in drug discovery, material science, bioconjugates, and agrochemical compounds.第六章 串聯(lián)反應(yīng)新進(jìn)展串聯(lián)反應(yīng)（Tandem reaction）串級反應(yīng)(Cascade reaction)多米諾反應(yīng)(Domino reaction)連續(xù)反應(yīng)(Sequential reaction)Tandem reactions, in which multiple reactions are combined into one synthetic operation, have been reported extensively in the synthetic chemistry literature. . Angew. Chem. Int. E