D-Galactose-D-plus-Galactose-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemED-GalactoseCat. No.: HY-N0210CAS No.: 59-23-4Synonyms: D-(+)-Galactose分式: CHO分量: 180.16作靶點(diǎn): Endogenous Metabolite作通路: Metabolic Enzyme/Protease儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) H2O :

2、 100 mg/mL (555.06 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 5.5506 mL 27.7531 mL 55.5062 mL5 mM 1.1101 mL 5.5506 mL 11.1012 mL10 mM 0.5551 mL 2.7753 mL 5.5506 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 D-Galactose天然的糖，是葡萄

3、糖的C-4差向異構(gòu)體。IC50 & Target Human Endogenous Metabolite體外研究Galactose is important for the survival and virulence of bacteria. In Escherichia coli galactose is utilized by1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEthe Leloir pathway. Two anomers of d-galactose are used for different purposes, -d-g

4、alactose as a carbonsource and -d-galactose for induction of UDP-galactose synthesis for biosynthetic glycosylation 1.體內(nèi)研究 Chronic D-galactose exposure induces neurodegeneration by enhancing caspase-mediated apoptosis andinhibiting neurogenesis and neuron migration in mice, as well as increasing oxi

5、dative damage. In addition, D-galactose-induced toxicity in mice is a useful model for studying the mechanisms of neurodegeneration andneuroprotective drugs and agents 2. D-galactose given by oral route causes cognitive impairments in ratswhich are accompanied by oxidative damage. Cognitive impairme

6、nts is observed in the open-field test in the4th and 6th weeks after d-gal administration, as well as an impairment in spatial memory in the radial mazetest after the 6th week of d-gal administration 3.PROTOCOLAnimal Rats: D-galactose is dissolved in water for administration at the dose of 100 mg/kg

7、 of body weight, and givenAdministration 23 by oral gavage, once a day, over a period of 1, 2, 4, 6 or 8 weeks. Animals are randomized into two groups:control animals (receiving water by oral gavage) or d-gal animals (receiving D-galactose by oral gavage). Thebehavioral tests and biochemical analysi

8、s are undertaken on the1st, 2nd, 4th, 6th and 8th weeks after thelast administration of d-gal 3.Mice: Male adult C57BL/6 mice are randomly divided into three groups (control, D-galactose, and D-galactose plus -LA). D-galactose (100 mg/kg) is injected subcutaneously (s.c.) daily into mice for 7 weeks

9、.-LA (100 mg/kg body weight) is injected peritoneally (i.p.) daily concomitantly for 7 weeks. All controlanimals are given saline 2.MCE has not independently confirmed the accuracy of these methods. They are for reference only.戶(hù)使本產(chǎn)品發(fā)表的科研獻(xiàn) PLoS Biol. 2018 Oct 18;16(10):e2006483.See more customer vali

10、dations on HYPERLINK / www.MedChemEREFERENCES1. Csiszovszki Z, et al. Structure and function of the D-galactose network in enterobacteria. MBio. 2011 Jun 28;2(4):e00053-11.2. Cui X, et al. Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidativedamage in mice: protectiveeffects of R-alpha-lipoic acid. J Neurosci Res. 2006 Aug 15;84(3):647-54.3. Budni J, et al. Oral administration of d-galactose induces cognitive impairments and oxidative damage in rats. Behav Brain Res. 2016Apr 1;302:35-43.McePdfHeightCaution: Product has not bee