BG45 - HDAC 抑制劑 - 生命科學試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBG45Cat. No.: HY-18712CAS No.: 926259-99-6分式: CHNO分量: 214.22作靶點: HDAC作通路: Cell Cycle/DNA Damage; Epigenetics儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 48 mg/mL (224.07 mM)* means solub

2、le, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 4.6681 mL 23.3405 mL 46.6810 mL5 mM 0.9336 mL 4.6681 mL 9.3362 mL10 mM 0.4668 mL 2.3340 mL 4.6681 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 BG45 is diluted in natural saline (NS)2.BIOLOGICAL ACTIVITY物活性 BG45個HDAC

3、I型抑制劑, 選擇性抑制HDAC3 (IC50=289 nM). BG45抑制HDAC1/2/ 6, 效降低 (IC50分別為2, 2.2, 和 20M)。IC50 & Target HDAC3 HDAC1 HDAC21/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE0.289 M (IC50) 2.0 M (IC50) 2.2 M (IC50)戶使本產(chǎn)品發(fā)表的科研獻 J Mol Med (Berl). 2019 Jun 14. Oncol Rep. 2018 Apr;39(4):1957-1965.See more customer valid

4、ations on HYPERLINK / www.MedChemEREFERENCES1. Iaconelli J, et al. HDAC6 Inhibitors Modulate Lys49 Acetylation and Membrane Localization of -Catenin in Human iPSC-DerivedNeuronal Cells. ACS Chemical Biology (2015), 10(3), 883-890.2. Tang D, et al. Metformin facilitates BG45-induced apoptosis via an anti-Warburg effect in cholangiocarcinoma cells. Oncol Rep. 2018Apr;39(4):1957-1965.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;F