Smurf1-IN-A01-A01-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESmurf1-IN-A01Cat. No.: HY-110195CAS No.: 1007647-73-5Synonyms: A01分式: CHClFNOS分量: 512.93作靶點(diǎn): Others作通路: Others儲(chǔ)存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 62.5 mg/mL

2、 (121.85 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.9496 mL 9.7479 mL 19.4958 mL5 mM 0.3899 mL 1.9496 mL 3.8992 mL10 mM 0.1950 mL 0.9748 mL 1.9496 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，

3、當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (4.06 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (4.06 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.Me

4、dChemE物活性 Smurf1-IN-A01 (A01)種泛素連接酶 Smad 泛素化調(diào)節(jié)因-1 (Smurf1) 抑制劑，kd 值為 3.664nM，Smurf1-IN-A01 通過抑制 Smurf1 介導(dǎo)的 Smad1/5 降解來提 BMP-2 的反應(yīng)性 1。IC50 & Target Kd: 3.664 nM (Smurf1) 1REFERENCES1. Cao Y, et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5degradation. Sci Rep. 2014 May 14;4:4965.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax