10β-17β-dihydroxyestra-1-4-dien-3-one-DHED-DataSheet-生命科學(xué)試劑-MedChemExpresss

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE10,17-dihydroxyestra-1,4-dien-3-oneCat. No.: HY-128976CAS No.: 549-02-0Synonyms: DHED分式: CHO分量: 288.38作靶點: Estrogen Receptor/ERR作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 25

2、0 mg/mL (866.91 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.4676 mL 17.3382 mL 34.6765 mL5 mM 0.6935 mL 3.4676 mL 6.9353 mL10 mM 0.3468 mL 1.7338 mL 3.4676 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建

3、議您現(xiàn)現(xiàn)配，當(dāng)天使；澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (7.21 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (7.21 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Maste

4、r of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.08 mg/mL (7.21 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 10,17-dihydroxyestra-1,4-dien-3-one (DHED)種靶向腦的雌激素 (estrogen) 前體。10,17-dihydroxyestra-1,4-dien-3-one (DHED)17-estradiol 的主物前藥，可降低腦部溫度調(diào)節(jié)功能障礙的發(fā)潮熱 1。體內(nèi)研究 10,17-dihydroxyestra-1,4-dien-3-one (D

5、HED), is an inactive bioprecursor prodrug of 17-estradiolconverting to 17-estradiol only in the brain. DHED as an E2-bioprecursor may be a viable approach fordelivering E2 selectively into the brain for the potential treatment of hot flushes 1.REFERENCES1. Merchenthaler I, et al. Treatment with an orally bioavailable prodrug of 17-estradiol alleviates hot flushes without hormonal effects inthe periphery. Sci Rep. 2016 Aug 1;6:30721.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37