1-2-Dioleoyl-sn-glycero-3-phosphoethanolamine-DOPE-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE1,2-Dioleoyl-sn-glycero-3-phosphoethanolamineCat. No.: HY-112005CAS No.: 4004-05-1Synonyms: DOPE分式: CHNOP分量: 744.03作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Pure form -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 3

2、1.25 mg/mL (42.00 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.3440 mL 6.7202 mL 13.4403 mL5 mM 0.2688 mL 1.3440 mL 2.6881 mL10 mM 0.1344 mL 0.6720 mL 1.3440 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

3、 (DOPE)陽(yáng)離脂質(zhì)體的中性輔助脂質(zhì) (helper lipid)，與陽(yáng)離磷脂結(jié)合，提裸 siRNA 的轉(zhuǎn)染效率。IC50 & Target IC50: helper lipid for liposome 1體外研究In this study, each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.11/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEmolar percent) 1.With the neutral lip

4、id for the LNP is DOPE, LNP exerts knock-down (KD) effectonmacrophages and DCs and Liposome-containing DOPE shows fusogenicity 1.LNP/siRNA significantlysuppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not onmonocytes, neutrophils, plasmacytoid DCs, or B cell

5、s 1.LNP has the potential to be an efficient siRNAdelivery system not only for murine but also for human macrophages and DCs 1.REFERENCES1. Uemura Y, et al. The efficiency of lipid nanoparticles with an original cationic lipid as a siRNA delivery system for macrophages anddendritic cells.Pharm Dev Technol. 2019 Mar;24(3):263-268.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0