TCMDC-135051-hydrochloride-DataSheet-生命科學試劑-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemETCMDC-135051hydrochlorideCat.No.:HY-126323B分?式:C??H??ClN?O?分?量:508.05作?靶點:Parasite作?通路:Anti-infection儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:83.33mg/mL(164.02mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.9683mL9.8416mL19.6831mL5mM0.3937mL1.9683mL3.9366mL10mM0.1968mL0.9842mL1.9683mL請根據(jù)產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。BIOLOGICALACTIVITY?物活性TCMDC-135051hydrochloride?種?選擇性和有效性的蛋?激酶PfCLK3抑制劑，具有低的靶外毒性。TCMDC-135051hydrochloride可以防?滋養(yǎng)體到裂殖體的轉變，破壞轉錄并減少向蚊?載體的傳播。TCMDC-135051hydrochloride具有抗寄??活性(EC50=320nM)。體外研究TCMDC-135051hydrochlorideshowspotentactivityagainstP.bergheisporozoitesinaliverinvasionanddevelopmentassayinwhichthecompoundshowsapEC50valueof6.17(EC50=0.40μM).ThekinaseassaysusingrecombinantPvCLK3(P.vivax)andPbCLK3(P.berghei)showthatTCMDC-135051hydrochloridehasnear-equipotentinhibitionatthesetwoorthologs,withpIC50valuesof7.47(IC50=0.033μ1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEM)and7.86(IC50=0.013μM),respectively[1].REFERENCES[1].AlamMM,etal.ValidationoftheproteinkinasePfCLK3asamultistagecross-speciesmalarialdrugtarget.Science.2019Aug30;365(6456).pii:eaau1682.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792