Thalidomide-NH-PEG2-COOH-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEThalidomide-NH-PEG2-COOHCat.No.:HY-138772CASNo.:2412056-45-0分?式:C??H??N?O?分?量:433.41作?靶點:E3LigaseLigand-LinkerConjugates作?通路:PROTAC儲存?式:-20°C,sealedstorage,awayfrommoistureandlight*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoistureandlight)溶解性數(shù)據(jù)體外實驗DMSO:125mg/mL(288.41mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.3073mL11.5364mL23.0728mL5mM0.4615mL2.3073mL4.6146mL10mM0.2307mL1.1536mL2.3073mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoistureandlight)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性Thalidomide-NH-PEG2-COOH?種合成的E3連接酶配體-linker偶聯(lián)物，包含于Thalidomide的cereblon配體和1個linker[1]。IC50&TargetCereblon體外研究PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaligandforanE3ubiquitinligaseandtheotherisforthetargetprotein.PROTACsexploittheintracellularubiquitin-proteasomesystemto1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEselectivelydegradetargetproteins[2].REFERENCES[1].SatoT,etal.Cereblon-BasedSmall-MoleculeCompoundstoControlNeuralStemCellProliferationinRegenerativeMedicine.FrontCellDevBiol.2021;9:629326.Published2021Mar11.[2].NalawanshaDA,etal.PROTACs:AnEmergingTherapeuticModalityinPrecisionMedicine.CellChemBiol.2020;27(8):998-1003.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589559