參考分析微生物-6bacteria

MedicalDepartmentofMicrobiology,SectionSectionIIIPathogenesisofBacterialZhao-HuaZhong,Ph.D.,Prof.Dept.ofMicrobiology,HMUBacterialManytypesMechanismsofbacterialAdherence:Fimbriae,afimbriaeInvasionfactors:enzymes,capsules,Exotoxins& KeyKeyOpportunisticInfectiousKoch’s

Extra/intracellularCompromisedAmicroorganismcapableofcausingIdentifyingIdentifyingBacteriaThatCauseDisease:Koch'spostulatesMolecularKoch’sMolecularKoch’sKnock-Knock-downExceptionsExceptionstoKoch’sTreponemapallidumMycobacteriumlepraenotbeNesseriagonorrhoeaeanimalmodelforitsE.coli(foodpoisoning,benormalflora,butcausediseaseswhenmovingtootherorgansMechanismsMechanismsofBacterialHostHostRespiratoryUrogenitalNormalskinandmucousmembranesprovidetheprimarydefenseagainstTocausedisease,pathogensmust thesebarriersBacterialBacterialVirulenceInvasionInvasionofhostcells&AntiphagocyticInvasiveIntracellularMicrocolony,E.coliwithE.E.coliStreptococcusStreptococcusInvasiveTissue-degradingCosmeticIgA

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KeyPropertiesof :heatExotoxins:A-BExotoxins:A-BBBACell eToxoids類毒素 ,butnolongerAntibodies(antitoxins抗毒素)DiphtheriaDiphtheriaToxin(白喉毒素&PseudomonasExotoxinribosylatedElongationFactor2CholeraCholeratoxinandE.colilabiletoxinAdenylatecyclaseShigaShigatoxin-Shiga-liketoxin-enterohemorraghicE.ofepithelialcellsofwaterbloodandBotulinumBotulinumTetanusInhibitsInhibitsFlacidInhibitsRigidExotoxinsExotoxins-ExtracellularMatrixofConnectiveTissueStaphylococcusMembraneDamagingMembraneDamagingDetergent-likeC.C.perfringensSepticSepticShwartzmanShwartzmanHypotension(tissuepoolingoffluids)DisseminatedWBCOverallsystemComparisonComparisonofExotoxinandSpecificSpecificImmunityandAnthrax(BacillusBrucellosis(BrucellaBotulism(ClostridiumbotulinumCholera(VibrioClostridiumperfringens(EpsilonE.coliO157:H7(Escherichia (YersiniaBacterialBacterialThemostfrequentThemostfrequentportalsofentryarethesiteswheremucousmembranesmeetwiththerespiratory(upper&lowergenital,urinary AnimalEnvironmenttoAirborneFood&SexualKeyfacts499millionsexuallytransmittedinfectionsoccuryearly(syphilis,gonorrhoea,chlamydiaandtrichomoniasis……)SexuallytransmittedinfectionsareanimportantcauseofinfertilityinmenandwomenDrug ,especiallyforgonorrhoea,isamajorthreattoSTIcontrolgloballySTIscanincreasetheriskofHIVacquisitionthree-foldorCommonbacterialNeisseriagonorrhoeae(causesgonorrhoeaorgonococcalinfection)Chlamydiatrachomatis(causeschlamydialTreponemapallidum(causesHaemophilusducreyi(causesKlebsiellagranulomatis(causesgranulomainguinaleorSexualTransmissionofBacterial ViralHuman (causesHerpessimplex 1andtype2(causesgenitalHumanpapilloma (causesgenitalwartsandcertainsubtypesleadtocervicalcancerinwomen)HepatitisB (causeshepatitisandchroniccasesmayleadtocanceroftheliver)Verticaltransmissionreferstotransmissionofaninfection,suchasHIV,hepatitisB,orhepatitisC,frommothertochildduringtheperinatalperiod,theperiod ybeforeandafterbirth

Horizontaltransmissionofabacterial,fungal,orviralinfectionbetweenmembersofthesamespeciesthatarenotinaparent-childTypesTypesofBacterialExogenousExogenousEndogenousInapparentSubclinicalApparentAcuteChoronicLocalSystemicTypesoftoilBacterial菌血

毒血

內(nèi)毒素血

敗血

膿毒 ThepresenceofbacteriaintheThedetectionofbacteriainthebloodisalwaysabnormalToxemia/bacteriaitselfmaynotenterorgrowintheSepticemiaPyemia敗血癥/ 敗血Adiseasecausedbythepresenceofpathogenicbacteriainthebloodstream,characterizedbychillsandfever 膿毒血typeofsepticaemiathatleadswidespreadabscessesofametastatictheblood,e.g.StaphylococcusSectionSectionIIIAntimicrobialImmune PathogenAlveolarMacrophageAttackingE.Defensespecific

天然免

獲得性免 NaturalNaturalBlood-1st2ndAntimicrobial2ndHumoralCellularHumoralCellular3rdInnate pleteNon-specificNon-specificImmune 補(bǔ) 溶菌 MemorialBMemorialBTcellPlasmaTcellMemorialTMemorialTActivatedcytolyticT

BBAcquiredAcquiredExtracellularExtracellular/Intracell