Basiliximab-CHI-621-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEBasiliximabCat.No.:HY-108852CASNo.:179045-86-4Synonyms:CHI621作?靶點(diǎn):InterleukinRelated作?通路:Immunology/Inflammation儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Basiliximab(CHI621)?種重組嵌合?/?IgG1單克隆抗?細(xì)胞介素2受體(interleukin-2receptor)抗體。Basiliximab可?于腎移植研究。IC50&TargetInterleukin-2receptor[1]體外研究BasiliximabspecificallyinhibitsTlymphocyteproliferationbybindingtotheIL-2Rα[1].Basiliximabbindsonlytoactivatedlymphocytesandmacrophages/monocytes[3].BasiliximabdoesnotaffectrestingTlymphocytesthatdonotexpressIL-2Rα[3].體內(nèi)研究Basiliximab(CHI621)(0.07mg/rat;i.v.;once)decreasestotalplacentalnaturalkillercellsinreduceduterineperfusionpressure(RUPP)rats[2].AnimalModel:Timed-pregnantSpragueDawley(SD)rats,reduceduterineperfusionpressure(RUPP)ratmodelofplacentalischemia[2]Dosage:0.07mg/ratAdministration:IVinfusion,onceResult:Decreasedtotalplacentalnaturalkillercells.HadnoeffecttolowerMAPorimprovepupweightandplacentalweight.REFERENCES1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[1].McKeageK,etal.Basiliximab:areviewofitsuseasinductiontherapyinrenaltransplantation.BioDrugs.2010Feb1;24(1):55-76.[2].CunninghamMW,etal.TheRoleofInterleukin‐2(IL‐2)inNaturalKillerCell(NK)ActivationandHypertensioninaPreclinicalRatModelofPreeclampsia.TheFASEBJournal,2018,32:911.1-911.1.[3].ChapmanTM,etal.Basiliximab:areviewofitsuseasinductiontherapyinrenaltransplantation.Drugs.2003;63(24):2803-35.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;0