Clavulanate-potassium-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEClavulanatepotassiumCat.No.:HY-A0256ACASNo.:61177-45-5分?式:C?H?KNO?分?量:237.25作?靶點:Bacterial;Antibiotic作?通路:Anti-infection儲存?式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實驗H2O:33.33mg/mL(140.48mM;ultrasonicandadjustpHto2withHCl)MassSolvent1mg5mg10mgConcentration制備儲備液1mM4.2150mL21.0748mL42.1496mL5mM0.8430mL4.2150mL8.4299mL10mM0.4215mL2.1075mL4.2150mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性Clavulanatepotassium?種?效的β-lactamase抑制劑，可作為抗?素[1][2]。IC50&Targetβ-lactamase[1]體外研究Clavulanatepotassiumhasweakantibacterialactivityagainstmostorganismswhenadministeredalone,butgivenincombinationwithbeta-lactamantibioticspreventsantibioticinactivationbymicrobiallactamase[1].1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEClavulanatepotassium(0.25mg/L,0.5mg/L)causesarelativelyslowinhibitionofgrowth,andahigherconcentration(1mg/L)isonlymarginallymoreeffectivethan0.5mg/L[2].戶使?本產(chǎn)品發(fā)表的科研?獻?NatCommun.2022Mar2;13(1):1116.?Genomics.2022:110527.?BiomedResInt.2018Jul2;2018:3579832.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].ReadingC,etal.ClavulanicAcid:aBeta-Lactamase-InhibitingBeta-LactamfromStreptomycesclavuligerus.AntimicrobAgentsChemother.1977May;11(5):852–857.[2].StokesDH,etal.Bactericidaleffectsofamoxycillin/clavulanicacidagainstintracellularLegionellapneumophilaintissueculturestudies.JAntimicrobChemother.1989Apr;23(4):547-56.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-