Echinocystic-acid-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEEchinocysticacidCat.No.:HY-N0271CASNo.:510-30-5分?式:C??H??O?分?量:472.7作?靶點(diǎn):ReactiveOxygenSpecies;Apoptosis作?通路:Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB;Apoptosis儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:≥100mg/mL(211.55mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.1155mL10.5775mL21.1551mL5mM0.4231mL2.1155mL4.2310mL10mM0.2116mL1.0578mL2.1155mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE1.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.75mg/mL(5.82mM);ClearsolutionBIOLOGICALACTIVITY?物活性Echinocysticacid從皂莢的果實(shí)中提取出來的五環(huán)三萜，有很強(qiáng)的抗氧化，抗炎癥和抗腫瘤的特性。REFERENCES[1].YangJHetal.EchinocysticacidinhibitsRANKL-inducedosteoclastogenesisbyregulatingNF-κBandERKsignalingpathways.BiochemBiophysResCommun.2016Sep2;477(4):673-7.[2].MaZetal.EchinocysticAcidInhibitsIL-1β-InducedCOX-2andiNOSExpressioninHumanOsteoarthritisChondrocytes.Inflammation.2016Apr;39(2):543-9.[3].LiSetal.Echinocysticacidreducesreserpine-inducedpain/depressiondyadinmice.MetabBrainDis.2016Apr;31(2):455-63.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58