Pristane-Norphytane-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPristaneCat.No.:HY-N7819CASNo.:1921-70-6Synonyms:Norphytane分?式:C??H??分?量:268.52作?靶點(diǎn):Others作?通路:Others儲存?式:Pureform-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:100mg/mL(372.41mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM3.7241mL18.6206mL37.2412mL5mM0.7448mL3.7241mL7.4482mL10mM0.3724mL1.8621mL3.7241mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請?jiān)?個?內(nèi)使?，-20°C儲存時，請?jiān)?個?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:≥2.5mg/mL(9.31mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(9.31mM);Clearsolution3.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(9.31mM);ClearsolutionBIOLOGICALACTIVITY?物活性Pristane(Norphytane)?種天然存在的烴油，在許多植物、各種海洋?物中少量發(fā)現(xiàn)，礦物油中最活躍的成分[1]。Pristane?種?抗原性佐劑，可在??中誘導(dǎo)MHCII類限制性關(guān)節(jié)炎T細(xì)胞[2]。體外研究PristaneactivatesCD4+αβTcellsthatareMHCclassIIrestrictedandarthritogenic[1].體內(nèi)研究PristaneactivatesCD4+alphabetaTcellsthatareMHCclassIIrestrictedandarthritogenicinvivo[2].AnimalModel:Naiverecipientrats(DA)[2]Dosage:500μLofPristaneoilAdministration:IntradermalinjectionResult:BothCD4+,CD8+αβTcellsandBcellssignificantlyexpandindraininglymphnodesuntilday6afterinjection,whereaftertheCD4+αβTcellscontinuetoexpanduntilday12afterinjection.REFERENCES[1].JJTurner,etal.KryptonFluoride:PreparationbytheMatrixIsolationTechnique.Science.1963May31;140(3570):974-5.[2].JensHolmberg,etal.Pristane,anon-antigenicadjuvant,inducesMHCclassII-restricted,arthritogenicTcellsintherat.JImmunol.2006Jan15;176(2):1172-9.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.