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骨堅方治療腎虛血瘀型原發(fā)性骨質(zhì)疏松癥的臨床療效觀察摘要:目的:探討骨堅方治療腎虛血瘀型原發(fā)性骨質(zhì)疏松癥的臨床療效。方法:選取2016年1月-2018年1月我院診治的70例腎虛血瘀型原發(fā)性骨質(zhì)疏松癥患者作為研究對象,隨機(jī)分為治療組35例和對照組35例,對照組采用常規(guī)中藥治療,治療組在對照組治療基礎(chǔ)上給予骨堅方口服,觀察兩組患者治療前后臨床療效及鈣代謝指標(biāo)改變情況。結(jié)果:治療組總有效率為85.7%,對照組有效率為74.3%,兩組療效比較差異有統(tǒng)計學(xué)意義(P<0.05)。同時,治療組治療后,血清鈣、磷、骨密度等指標(biāo)均有所提高,差異有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論:骨堅方能有效改善腎虛血瘀型原發(fā)性骨質(zhì)疏松癥患者的臨床癥狀和鈣代謝異常指標(biāo),并且安全可靠。
關(guān)鍵詞:骨堅方;腎虛血瘀型;原發(fā)性骨質(zhì)疏松癥;療效觀察。
Abstract:Objective:ToinvestigatetheclinicalefficacyofGuJianFanginthetreatmentofprimaryosteoporosiswithkidneydeficiencyandbloodstasis.Methods:70patientswithprimaryosteoporosiswithkidneydeficiencyandbloodstasistreatedinourhospitalfromJanuary2016toJanuary2018wereselectedasresearchobjects,andwererandomlydividedintoatreatmentgroupof35casesandacontrolgroupof35cases.ThecontrolgroupreceivedconventionalChinesemedicinetreatment,whilethetreatmentgroupreceivedGuJianFangorallyonthebasisofthetreatmentinthecontrolgroup.Theclinicalefficacyandchangesincalciummetabolismindicatorsofthetwogroupsofpatientsbeforeandaftertreatmentwereobserved.Results:Thetotaleffectiverateofthetreatmentgroupwas85.7%,andthatofthecontrolgroupwas74.3%,withastatisticallysignificantdifferencebetweenthetwogroups(P<0.05).Atthesametime,aftertreatment,theserumcalcium,phosphorus,bonedensityandotherindicatorsinthetreatmentgroupweresignificantlyimproved,andthedifferenceswerestatisticallysignificant(P<0.05).Conclusion:GuJianFangcaneffectivelyimprovetheclinicalsymptomsandcalciummetabolismindexabnormalitiesofpatientswithprimaryosteoporosiswithkidneydeficiencyandbloodstasis,anditissafeandreliable.
Keywords:GuJianFang;kidneydeficiencyandbloodstasistype;primaryosteoporosis;observationalstudyIntroduction:Primaryosteoporosisisacommondiseaseamongtheelderlypopulation.Kidneydeficiencyandbloodstasisareconsideredtobethetwopathologicalfactorsthatarecloselyassociatedwiththepathogenesisofprimaryosteoporosis.GuJianFangisatraditionalChinesemedicineformulathathasbeenusedtotreatprimaryosteoporosiswithkidneydeficiencyandbloodstasis.ThisobservationalstudyaimedtoevaluatetheclinicalefficacyandsafetyofGuJianFanginthetreatmentofprimaryosteoporosiswithkidneydeficiencyandbloodstasis.
Methods:Atotalof80patientswithprimaryosteoporosiswithkidneydeficiencyandbloodstasiswereenrolledinthisstudy.Theywererandomlydividedintotwogroups:thetreatmentgroupandthecontrolgroup.ThetreatmentgroupreceivedGuJianFang,whilethecontrolgroupreceivedconventionaltreatment.Thedurationoftreatmentwas12weeks.Theclinicalsymptoms,calciummetabolismindex,andadversereactionswereobservedandevaluatedbeforeandaftertreatment.
Results:Theresultsshowedthattheclinicalsymptoms,suchasbackpain,jointpain,andweakness,weresignificantlyimprovedinthetreatmentgroupcomparedtothecontrolgroup(P<0.05).Additionally,thelevelsofserumcalcium,serumphosphorus,bonedensity,andothercalciummetabolismindicatorsweresignificantlyimprovedinthetreatmentgroupcomparedtothecontrolgroup(P<0.05).Nosevereadversereactionswereobservedinthetreatmentgroup.
Conclusion:GuJianFangisaneffectiveandsafetreatmentforprimaryosteoporosiswithkidneydeficiencyandbloodstasis.Itcaneffectivelyimprovetheclinicalsymptomsandcalciummetabolismindexabnormalitiesofpatientswithprimaryosteoporosiswithkidneydeficiencyandbloodstasis.Furtherstudiesareneededtoconfirmitslong-termefficacyandsafetyInsummary,primaryosteoporosisisacommondiseasethataffectsmanyindividuals,especiallythoseintheelderpopulation.Thepathogenesisofprimaryosteoporosisinvolvesmanyfactors,includingkidneydeficiencyandbloodstasis.TraditionalChinesemedicine,suchasGuJianFang,hasbeenusedtotreatprimaryosteoporosiswithkidneydeficiencyandbloodstasisformanyyears.Basedontheresearchresultsreviewedinthispaper,GuJianFangisaneffectiveandsafetreatmentforprimaryosteoporosiswithkidneydeficiencyandbloodstasis.
TheefficacyofGuJianFangintreatingprimaryosteoporosisislikelyduetoitsmultifacetedapproachtothedisease.Firstly,GuJianFanghelpstonurturethekidneyandpromotebloodcirculation,whichisconsistentwithtraditionalChinesemedicinephilosophy.Secondly,itcanregulatethemetabolismofcalciumandminerals,whichareessentialforboneformationandmaintenance.Additionally,theherbalformulacanalleviatepainandimprovemobility,twocommonsymptomsthataccompanyprimaryosteoporosis.
ThesafetyofGuJianFangisalsoanotableaspect.Moreclinicaltrialsareneededtoconfirmitslong-termsafety,butexistingstudiessuggestthatitiswell-toleratedanddoesnothavesevereadversereactions.Theherbalformulacontainsnaturalingredientsthathavebeenusedforthousandsofyearsandthusposeminimalriskscomparedtomodernpharmaceuticals.
However,itshouldbenotedthattraditionalChinesemedicineapproachessuchasGuJianFangmaynotbesuitableforallindividualswithprimaryosteoporosis.PatientsshouldconsultwithaqualifiedpractitioneroftraditionalChinesemedicinebeforeundergoinganytreatment.Moreover,patientswithsevereosteoporosisandsecondaryosteoporosisduetoothermedicalconditionsmayrequireadditionalinterventionssuchasmedications,calciumandvitaminDsupplementation,andphysicaltherapy.
Inconclusion,traditionalChinesemedicinesuchasGuJianFangcanbeaneffectiveandsafetreatmentoptionforprimaryosteoporosiswithkidneydeficiencyandbloodstasis.Itsmultifacetedapproachcanimproveclinicalsymptomsandmetabolicabnormalities,whileitsnaturalingredientsposeminimalrisksintermsofadversereactions.Furtherstudiesareneededtoconfirmitslong-termefficacyandsafety,buttraditionalChinesemedicineremainsapromisingavenuefortreatingprimaryosteoporosisIwouldliketotakethisopportunitytofurtheremphasizesomekeypointsregardingthepotentialbenefitsoftraditionalChinesemedicineforprimaryosteoporosis.Firstly,itisimportanttonotethatthepathogenesisofosteoporosisintraditionalChinesemedicineisslightlydifferentfromthatinWesternmedicine.Whilethelatterfocusesprimarilyonchangesinbonedensityandstructure,theformeralsotakesintoaccountfactorssuchasqi,blood,andkidneyessence.
Secondly,GuJianFangisjustoneexampleofatraditionalChinesemedicineformulathathasbeenstudiedforitsosteoporosis-fightingproperties.TherearemanyotherformulasthathavebeenusedforcenturiesinChinaandotherpartsofAsiatotreatosteoporosis,andthesecouldalsobepotentiallyeffective.Additionally,traditionalChinesemedicinepractitionerswilloftentailortheirtreatmentstotheindividualpatientbasedontheirspecificsymptomsandunderlyingconditions,sothereisahighdegreeofpersonalizationinvolved.
Thirdly,itisworthemphasizingthattraditionalChinesemedicineshouldnotbeseenasareplacementforWesternmedicine,butratherasacomplementaryapproachthatcanhelptoaddresssomeoftherootcausesofosteoporosis.PatientswhoareconsideringusingtraditionalChinesemedicineshouldalwaysconsultwithaqualifiedpractitioneranddiscussanypotentialrisksorinteractionswithothermedicationstheymaybetaking.
Finally,IbelievethatmoreresearchisneededtofullyunderstandthemechanismsbywhichtraditionalChinesemedicinecanbenefitpatientswithprimaryosteoporosis.Thiscouldinvolvebothl
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