實(shí)驗(yàn)室常用化療藥物

1紫杉醇(paclitaxol)分子式：C47H51NO14分子量：853.92CAS號(hào)：33069-62-4藥理：促進(jìn)微管聚合和穩(wěn)定已聚合的微管，抑制有絲分裂。關(guān)鍵詞：tubulinbinding，mitosisinhibition代表文獻(xiàn)： WallME.Camptothecinandtaxol:discoverytoclinic--thirteenthBruceF.CainMemorialAwardLecture.Cancerresearch.1995,55(4):753-60.全文鏈接：/pubmed/78507852多烯紫杉醇(Docetaxel)分子式：C43H53NOm分子量：807.88CAS號(hào)：114977-28-5

關(guān)鍵詞：microtubulesbinding,stabilizedmicrotubles,關(guān)鍵詞：microtubulesapoptosis代表文獻(xiàn)：YvonAM,WadsworthP,JordanMA(April1999).”TaxolSuppressesDynamicsofIndividualMicrotubulesinLivingHumanTumorCell.”Mol.Biol.Cell10(4):947-59.3阿霉素(Doxorubicin/Adriamycin)分子式:C27H29NO11分子式:C27H29NO11分子量:579.99CAS號(hào):23214-92-8關(guān)鍵詞:代表文獻(xiàn):關(guān)鍵詞:代表文獻(xiàn):DNAintercalating,macromolecularbiosynthesisinhibitionMomparlerRL,KaronM,SiegelSE,AvilaF(August1976)"EffectofadriamycinonDNA,RNA,andproteinsynthesisincell-freesystemsandintactcells.CancerRes36(8):2891-5.4毗柔比星(Pirarubicin)分子式：c32h37noi2分子量：627.63CAS號(hào)：72496-41-4關(guān)鍵詞：intercalating,DNAandRNAsynthesisinhibition,topoisomeraseIIenzymeinhibition文獻(xiàn)：ZhengSE,Pirarubicininhibitsmultidrug-resistantosteosarcomacellproliferationthroughinductionofG(2)/Mphasecellcyclearrest.ActaPharmacolSin.2012,5網(wǎng)址：/pubmed/225807405 5-氟尿嘧啶(5-Flurouracil)分子式：C4H3FN2O2分子量：130.08CAS號(hào)：51-21-8X"關(guān)鍵詞：suicideinhibitor,thymidylatesynthaseinhibition文獻(xiàn)：LongleyDB,HarkinDP,JohnstonPG(May2003).”5-fluorouracil:mechanismsofactionandclinicalstrategies”.Nat.Rev.Cancer3(5):

330-8.doi:10.1038/nrc10746鹽酸伊立替康(IrinotecanHydrochloride)分子式：C33H38N4O6-HCI-3H2°分子量：677.19CAS號(hào)：100286-90-6關(guān)鍵詞：topoisomeraseIenzymeinhibition文獻(xiàn):O'DwyerPJ,CatalanoRB(October2006).”Uridinediphosphateglucuronosyltransferase(UGT)1A1andirinotecan:practicalpharmacogenomicsarrivesincancertherapy"J.Clin.Onc(24(28):4534-8.doi:10.1200/JCO.2006.07.30317索拉菲尼(sorafenib)分子式：CHClFNO116 343分子量：464.825CAQ號(hào)? zHHCAS號(hào)：284461-73-0HH°T...文獻(xiàn):關(guān)鍵詞：tyrosineproteinkinasesinhibition,Rafkinasesinhibition文獻(xiàn):KeatingGM,SantoroA.(2009).”Sorafenib:AReviewofitsUsein

AdvancedHepatocellularCarcinoma"Drugs69(2):223240.doi:10.2165/00003495-200969020-000068替尼泊苷(Teniposide)分子式：C32H32O13S分子量：656.655CAS號(hào):CAS號(hào):29767-20-2'關(guān)鍵詞DNAandDNA-proteincross-linksbreak,關(guān)鍵詞topoisomeraseIIenzymeinhibition文獻(xiàn):AnejaR,Multidrugresistance-associatedprotein-overexpressingteniposide-resistanthumanlymphomasundergoapoptosisbyatubulin-bindingagent.CancerRes.2008網(wǎng)址：/pubmed/183166149舒尼替尼(Sunitinib)分子式：C22H27FN4O2分子量：398.474CAS號(hào)：341031-54-7關(guān)鍵詞:關(guān)鍵詞:文獻(xiàn):multiplerecepto