過渡金屬催化芳香化合物碳氫鍵活化課件

TransitionMetal-CatalyzedC-HBondActivationofAromaticCompounds：Chelation-AssistedOrtho-Functionalization

TransitionMetal-CatalyzedC-HOutlineIntroductionCatalyticOrtho-FunctionalizationConclusionandOutlookOutlineIntroductionIntroductionIntroductionIntroductionLewis,L.N.;Smith,J.F,J.Am.Chem.Soc.

1986,108,2728IntroductionLewis,L.N.;SmithIntroductionMurai,S.;etal.Nature1993,366,529IntroductionMurai,S.;etal.IntroductionIntroductionAdvantagesHighselectivityAtomeconomyCleanandeconomicalprocessAdvantagesHighselectivityCatalyticOrtho-FunctionalizationOrtho-AlkylationOrtho-ArylationOrtho-CarbonylationOthersCatalyticOrtho-FunctionalizatOrtho-AlkylationJun,C.H.Angew.Chem.Int.Ed.

2000,

39,3440Ortho-AlkylationJun,C.H.AngOrtho-AlkylationAhrendt,K.A.;etal.Org.Lett.2003,5,1301Ortho-AlkylationAhrendt,K.A.Ortho-AlkylationThalji,R.K.;etal.J.Am.Chem.Soc.2004,126,7192Ortho-AlkylationThalji,R.K.;Ortho-AlkylationChenX.;etal.J.Am.Chem.Soc.2006,128,12634Ortho-AlkylationChenX.;etalOrtho-ArylationOrtho-ArylationOrtho-ArylationKakiuchi,F.;etal.J.Am.Chem.Soc.

2003,125,1698.J.Am.Chem.Soc.

2005,127,5936Ortho-ArylationKakiuchi,F.;eOrtho-ArylationKakiuchi,F.;etal.J.Am.Chem.Soc.

2005,127,5936Ortho-ArylationKakiuchi,F.;e過渡金屬催化芳香化合物碳氫鍵活化課件Ortho-ArylationWanX.B.,etal.J.Am.Chem.Soc.2006,128,7416.PunnaS,etal.Synlett

2004,13,2351.RodriguezN.;etal.J.Org.Chem.

2004,69,8070.ShiZJ.;etal.Angew.Chem.Int.Ed.

2007,

46,5554Ortho-ArylationWanX.B.,etaOrtho-ArylationOrtho-ArylationOrtho-ArylationKalyani,D.;etal.J.Am.Chem.Soc.2005,127,7330Ortho-ArylationKalyani,D.;etOrtho-ArylationOrtho-ArylationOrtho-ArylationOrtho-ArylationOrtho-ArylationOrtho-ArylationOrtho-ArylationShabashov,D.;Daugulis,O.Org.Lett.2005,7,3657Ortho-ArylationShabashov,D.;Ortho-CarbonylationMoore,E.J.;etal.J.Am.Chem.Soc.1992,114,5888Ortho-CarbonylationMoore,E.JOrtho-CarbonylationFukuyama,T.;etal.J.Org.

Chem.1997,62,5647Ortho-CarbonylationFukuyama,TOrtho-SilylationKakiuchi,F.;etal.Chem.Lett.2001,422.Chem.Lett.2002,396Ortho-SilylationKakiuchi,F.;Kakiuchi,F.;etal.Chem.Lett.1995,681Jia,C.;etal.Science2000,287,1992Kakiuchi,F.;etal.Chem.LetKuninobuY.;etal.Angew.Chem.Int.Ed.

2007,

46,6518KuninobuY.;etal.Angew.ChemConclusionandOutlookOutstandingresultshavebeenobtainedinselectivityandatomeconomy.ThesedevelopmentwillhelpbothsyntheticandmaterialchemistagreatdealDevelopme