Theophylline-Standard-1-3-Dimethylxanthine-Standard-DataSheet-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemETheophylline(Standard)Cat.No.:HY-B0809RCASNo.:58-55-9Synonyms:1,3-Dimethylxanthine(Standard);Theo-24(Standard)分?式:C?H?N?O?分?量:180.16作?靶點(diǎn):Phosphodiesterase(PDE);AdenosineReceptor;HDAC;Apoptosis;InterleukinRelated;TNFReceptor;EndogenousMetabolite作?通路:MetabolicEnzyme/Protease;GPCR/GProtein;CellCycle/DNADamage;Epigenetics;Apoptosis;Immunology/Inflammation儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實(shí)驗(yàn)0.1MNaOH:20mg/mL(111.01mM;ultrasonicandwarmingandadjustpHto10with0.1MNaOHandheatto60°C)DMSO:11.11mg/mL(61.67mM;Needultrasonic)H2O:5mg/mL(27.75mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM5.5506mL27.7531mL55.5062mL5mM1.1101mL5.5506mL11.1012mL10mM0.5551mL2.7753mL5.5506mLBIOLOGICALACTIVITY?物活性Theophylline(Standard)Theophylline的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Theophylline(1,3-Dimethylxanthine)有效的磷酸?酯酶(PDE)抑制劑，腺苷受體拮抗劑，和組蛋?脫?酰酶(HDAC)活化劑。Theophylline(1,3-Dimethylxanthine)抑制PDE3活性，放松?道平滑肌。Theophylline(1,3-Dimethylxanthine)通過(guò)增加IL-10和抑制NF-κB進(jìn)?細(xì)胞核?具有抗炎活性。Theophylline(1,3-1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEDimethylxanthine)誘發(fā)細(xì)胞凋亡(apoptosis)。Theophylline(1,3-Dimethylxanthine)可?于哮喘和慢性阻塞性肺疾病(COPD)的研究。IC50&TargetHumanEndogenousIL-10IL-6PDE3Metabolite戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?CellRepMed.2023May24;101061.?IntJMolSci.2023,24(2),1019.?PharmacolResPerspect.2020Apr;8(2):e00575.?EurJDrugMetabPharmacokinet.2022Jun22.?ResearchSquarePreprint.2020Oct.Seemorecustomervalidationsonwww.MedChemEMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;02