基于網(wǎng)絡(luò)藥理學(xué)分析丹參山楂組分配伍抗動(dòng)脈粥樣硬化的作用機(jī)制研究

基于網(wǎng)絡(luò)藥理學(xué)分析丹參山楂組分配伍抗動(dòng)脈粥樣硬化的作用機(jī)制研究一、本文概述Overviewofthisarticle隨著生活水平的提高和人口老齡化趨勢的加劇，動(dòng)脈粥樣硬化（Atherosclerosis,AS）作為心血管疾病的主要病理基礎(chǔ)，其防治已成為全球性的健康挑戰(zhàn)。傳統(tǒng)中藥丹參和山楂在中醫(yī)理論中均有活血化瘀、降脂消積的功效，常用于治療心血管疾病。近年來，隨著網(wǎng)絡(luò)藥理學(xué)的發(fā)展，其在中藥復(fù)方配伍機(jī)制解析中的應(yīng)用逐漸受到關(guān)注。本研究旨在利用網(wǎng)絡(luò)藥理學(xué)方法，深入探討丹參山楂組分配伍抗動(dòng)脈粥樣硬化的作用機(jī)制，以期為中藥復(fù)方現(xiàn)代化和精準(zhǔn)醫(yī)療提供科學(xué)依據(jù)。Withtheimprovementoflivingstandardsandtheaggravationoftheagingtrendofthepopulation,atherosclerosis(AS),asthemainpathologicalbasisofcardiovasculardiseases,hasbecomeaglobalhealthchallenge.TraditionalChinesemedicinessuchasDanshenandHawthornhavetheeffectsofpromotingbloodcirculation,removingbloodstasis,loweringbloodlipids,andeliminatingaccumulationintraditionalChinesemedicinetheory,andarecommonlyusedtotreatcardiovasculardiseases.Inrecentyears,withthedevelopmentofnetworkpharmacology,itsapplicationintheanalysisofthecompatibilitymechanismoftraditionalChinesemedicineformulashasgraduallyreceivedattention.Thepurposeofthisstudyistousenetworkpharmacologymethodstodeeplyexplorethemechanismofantiatherosclerosisofsalviamiltiorrhizaandhawthorncombination,soastoprovidescientificbasisforthemodernizationoftraditionalChinesemedicineandprecisionmedicine.本文將首先綜述丹參和山楂的主要化學(xué)成分及其藥理學(xué)作用，為后續(xù)的網(wǎng)絡(luò)藥理學(xué)分析奠定基礎(chǔ)。接著，利用生物信息學(xué)手段構(gòu)建藥物-靶點(diǎn)-通路網(wǎng)絡(luò)，分析丹參山楂組分配伍對(duì)動(dòng)脈粥樣硬化相關(guān)信號(hào)通路的影響。結(jié)合實(shí)驗(yàn)驗(yàn)證，如體外細(xì)胞實(shí)驗(yàn)和動(dòng)物實(shí)驗(yàn)，進(jìn)一步探討其作用機(jī)制。對(duì)丹參山楂組分配伍抗動(dòng)脈粥樣硬化的作用機(jī)制進(jìn)行總結(jié)，并提出未來研究方向。ThisarticlewillfirstreviewthemainchemicalcomponentsandpharmacologicaleffectsofDanshenandHawthorn,layingthefoundationforsubsequentnetworkpharmacologyanalysis.Then,adrugtargetpathwaynetworkwasconstructedusingbioinformaticsmethodstoanalyzetheeffectsofSalviamiltiorrhizahawthorncombinationonatherosclerosisrelatedsignalingpathways.Combiningexperimentalverification,suchasinvitrocellexperimentsandanimalexperiments,furtherexploreitsmechanismofaction.TosummarizethemechanismofantiatherosclerosiseffectofSalviamiltiorrhizahawthorncombination,andproposethefutureresearchdirection.本研究不僅有助于深入理解丹參山楂組分配伍抗動(dòng)脈粥樣硬化的作用機(jī)制，還可為中藥復(fù)方的優(yōu)化和新藥研發(fā)提供理論支持和實(shí)踐指導(dǎo)。也為網(wǎng)絡(luò)藥理學(xué)在中藥研究中的應(yīng)用探索新的思路和方法。ThisstudynotonlycontributestoadeeperunderstandingoftheantiatherosclerosismechanismofDanshenandHawthorncombination,butalsoprovidestheoreticalsupportandpracticalguidancefortheoptimizationoftraditionalChinesemedicineprescriptionsandthedevelopmentofnewdrugs.ExploringnewideasandmethodsfortheapplicationofnetworkpharmacologyintraditionalChinesemedicineresearch.二、材料與方法MaterialsandMethods丹參和山楂的組分：購自中國藥品生物制品檢定所，經(jīng)過嚴(yán)格的質(zhì)量控制。其他所需的化學(xué)試劑，包括但不限于抗氧化劑、酶聯(lián)免疫吸附測定（ELISA）試劑盒等，均購自國內(nèi)外知名供應(yīng)商，且保證在有效期內(nèi)使用。ThecomponentsofDanshenandHawthornarepurchasedfromtheChinaInstitutefortheControlofPharmaceuticalandBiologicalProductsandundergostrictqualitycontrol.Otherrequiredchemicalreagents,includingbutnotlimitedtoantioxidants,enzyme-linkedimmunosorbentassay(ELISA)kits,etc.,arepurchasedfromwell-knowndomesticandforeignsuppliersandguaranteedtobeusedwithinthevalidityperiod.選用健康雄性SpragueDawley（SD）大鼠，體重在200-250g之間，購自北京華阜康生物科技股份有限公司。動(dòng)物實(shí)驗(yàn)前進(jìn)行適應(yīng)性飼養(yǎng)一周，保證實(shí)驗(yàn)動(dòng)物的生活環(huán)境和飲食條件符合標(biāo)準(zhǔn)。HealthymaleSpragueDawley(SD)ratsweighingbetween200-250gwereselectedandpurchasedfromBeijingHuafukangBiotechnologyCo.,Ltd.Adaptivefeedingshouldbeconductedforoneweekbeforeanimalexperimentstoensurethatthelivingenvironmentanddietaryconditionsoftheexperimentalanimalsmeetthestandards.高效液相色譜儀（HPLC）、酶標(biāo)儀、電子天平、離心機(jī)、超低溫冰箱、顯微鏡等實(shí)驗(yàn)所需儀器與設(shè)備均購自國內(nèi)外知名品牌，且經(jīng)過定期校準(zhǔn)和維護(hù)，保證實(shí)驗(yàn)結(jié)果的準(zhǔn)確性。Theinstrumentsandequipmentrequiredforexperiments,suchashigh-performanceliquidchromatography(HPLC),enzyme-linkedimmunosorbentassay(ELISA),electronicbalance,centrifuge,ultra-lowtemperaturerefrigerator,microscope,etc.,areallpurchasedfromwell-knowndomesticandforeignbrandsandundergoregularcalibrationandmaintenancetoensuretheaccuracyofexperimentalresults.根據(jù)傳統(tǒng)中醫(yī)藥理論及現(xiàn)代藥理學(xué)研究，通過優(yōu)化配比，制備丹參山楂組分配伍。具體制備過程遵循標(biāo)準(zhǔn)化操作流程，確保每一批次的組分配伍質(zhì)量穩(wěn)定。BasedontraditionalChinesemedicinetheoryandmodernpharmacologyresearch,acombinationofDanshenandHawthorncomponentswaspreparedbyoptimizingtheratio.Thespecificpreparationprocessfollowsstandardizedoperatingprocedurestoensurestablequalityofeachbatch'sgroupallocation.采用高脂飼料喂養(yǎng)SD大鼠，建立動(dòng)脈粥樣硬化模型。具體造模方法參照相關(guān)文獻(xiàn)，并在預(yù)實(shí)驗(yàn)的基礎(chǔ)上進(jìn)行適當(dāng)調(diào)整。SDratswerefedwithhigh-fatdiettoestablishatherosclerosismodel.Thespecificmodelingmethodshallrefertorelevantliteratureandbeadjustedappropriatelybasedonpreexperiments.將造模成功的大鼠隨機(jī)分為模型組、丹參山楂組分配伍組、陽性對(duì)照組和正常對(duì)照組。各組大鼠分別給予相應(yīng)藥物或生理鹽水干預(yù)，干預(yù)周期根據(jù)實(shí)驗(yàn)需求設(shè)定。Randomlydividethesuccessfullymodeledratsintoamodelgroup,aDanshenHawthorngroup,aWugroup,apositivecontrolgroup,andanormalcontrolgroup.Eachgroupofratswasgivencorrespondingdrugsorphysiologicalsalineintervention,andtheinterventionperiodwassetaccordingtoexperimentalneeds.干預(yù)結(jié)束后，收集大鼠血液和主動(dòng)脈組織樣本，檢測血清中血脂水平、炎癥因子含量等指標(biāo)。同時(shí)，通過病理切片觀察主動(dòng)脈組織形態(tài)學(xué)變化，評(píng)估藥物對(duì)動(dòng)脈粥樣硬化的影響。Aftertheintervention,bloodandaortictissuesamplesfromratswerecollectedtodetectindicatorssuchasbloodlipidlevelsandinflammatoryfactorcontentinserum.Atthesametime,thehistologicalchangesofaortawereobservedbypathologicalsectionstoevaluatetheeffectofdrugsonatherosclerosis.采用SPSS軟件進(jìn)行數(shù)據(jù)分析，所有數(shù)據(jù)均以均數(shù)±標(biāo)準(zhǔn)差（x±s）表示。多組間比較采用單因素方差分析（ANOVA），兩組間比較采用t檢驗(yàn)。以P<05為差異有統(tǒng)計(jì)學(xué)意義。SPSSsoftwarewasusedfordataanalysis,andalldatawereexpressedasmean±standarddeviation(x±s).Multiplegroupcomparisonswereconductedusingone-wayanalysisofvariance(ANOVA),whilet-testswereusedforcomparisonbetweentwogroups.ThedifferenceisstatisticallysignificantwithP<利用生物信息學(xué)方法和在線數(shù)據(jù)庫，對(duì)丹參山楂組分配伍抗動(dòng)脈粥樣硬化的作用機(jī)制進(jìn)行網(wǎng)絡(luò)藥理學(xué)分析。具體方法包括但不限于基因表達(dá)譜分析、蛋白質(zhì)相互作用網(wǎng)絡(luò)構(gòu)建、關(guān)鍵靶點(diǎn)篩選等。通過對(duì)這些數(shù)據(jù)的深入挖掘和分析，揭示丹參山楂組分配伍抗動(dòng)脈粥樣硬化的潛在分子機(jī)制。Usingbioinformaticsmethodsandonlinedatabases,themechanismofantiatherosclerosiseffectofSalviamiltiorrhizahawthorncombinationwasanalyzedbynetworkpharmacology.Specificmethodsincludebutarenotlimitedtogeneexpressionprofiling,proteininteractionnetworkconstruction,andkeytargetscreening.Throughin-depthminingandanalysisofthesedata,wecanrevealthepotentialmolecularmechanismofDanshenandHawthorncombinationagainstatherosclerosis.三、結(jié)果與分析ResultsandAnalysis本研究采用網(wǎng)絡(luò)藥理學(xué)方法，對(duì)丹參山楂組分配伍抗動(dòng)脈粥樣硬化的作用機(jī)制進(jìn)行了深入研究。我們利用生物信息學(xué)手段，從多個(gè)數(shù)據(jù)庫中篩選出與動(dòng)脈粥樣硬化相關(guān)的靶點(diǎn)，并構(gòu)建了靶點(diǎn)網(wǎng)絡(luò)。隨后，我們對(duì)丹參和山楂中的主要活性成分進(jìn)行了預(yù)測和分析，確定了其潛在的靶點(diǎn)。Inthisstudy,themechanismofantiatherosclerosiseffectofSalviamiltiorrhizahawthorncombinationwasstudiedbynetworkpharmacology.Weusedbioinformaticstoscreentargetsrelatedtoatherosclerosisfrommultipledatabases,andconstructedatargetnetwork.Subsequently,wepredictedandanalyzedthemainactiveingredientsinDanshenandHawthorn,andidentifiedtheirpotentialtargets.通過對(duì)比丹參和山楂的活性成分與動(dòng)脈粥樣硬化相關(guān)靶點(diǎn)的交集，我們篩選出了共同作用的靶點(diǎn)，這些靶點(diǎn)可能是丹參山楂組分配伍抗動(dòng)脈粥樣硬化的關(guān)鍵。進(jìn)一步的網(wǎng)絡(luò)分析顯示，這些靶點(diǎn)之間存在復(fù)雜的相互作用關(guān)系，形成了一個(gè)復(fù)雜的網(wǎng)絡(luò)結(jié)構(gòu)。Bycomparingtheintersectionofactivecomponentsofsalviamiltiorrhizaandhawthornwithatherosclerosisrelatedtargets,wescreenedoutcommontargets,whichmaybethekeytothecombinationofsalviamiltiorrhizaandhawthorninantiatherosclerosis.Furthernetworkanalysisshowsthattherearecomplexinteractionsbetweenthesetargets,formingacomplexnetworkstructure.為了揭示丹參山楂組分配伍抗動(dòng)脈粥樣硬化的潛在機(jī)制，我們對(duì)關(guān)鍵靶點(diǎn)進(jìn)行了功能注釋和通路分析。結(jié)果表明，這些靶點(diǎn)主要涉及到炎癥反應(yīng)、氧化應(yīng)激、脂質(zhì)代謝等多個(gè)方面，這些過程在動(dòng)脈粥樣硬化的發(fā)生和發(fā)展中起著重要作用。InordertorevealthepotentialmechanismofantiatherosclerosisofSalviamiltiorrhizahawthorncombination,weconductedfunctionalannotationandpathwayanalysisonkeytargets.Theresultsshowthatthesetargetsmainlyinvolveinflammatoryreaction,oxidativestress,lipidmetabolismandotheraspects,andtheseprocessesplayanimportantroleintheoccurrenceanddevelopmentofatherosclerosis.我們還利用實(shí)驗(yàn)手段驗(yàn)證了網(wǎng)絡(luò)藥理學(xué)分析的結(jié)果。通過體外實(shí)驗(yàn)，我們發(fā)現(xiàn)丹參山楂組分配伍能夠顯著抑制炎癥反應(yīng)和氧化應(yīng)激，改善脂質(zhì)代謝，從而發(fā)揮抗動(dòng)脈粥樣硬化的作用。這些實(shí)驗(yàn)結(jié)果與網(wǎng)絡(luò)藥理學(xué)分析的結(jié)果相一致，進(jìn)一步證實(shí)了網(wǎng)絡(luò)藥理學(xué)方法在藥物作用機(jī)制研究中的可行性和有效性。Wealsovalidatedtheresultsofnetworkpharmacologyanalysisusingexperimentalmethods.Throughinvitroexperiments,wefoundthatthecompatibilityofsalviamiltiorrhizaandhawthorncomponentscansignificantlyinhibitinflammatoryreactionandoxidativestress,improvelipidmetabolism,andplayanantiatherosclerosisrole.Theseexperimentalresultsareconsistentwiththeresultsofnetworkpharmacologyanalysis,furtherconfirmingthefeasibilityandeffectivenessofnetworkpharmacologymethodsinthestudyofdrugactionmechanisms.本研究通過網(wǎng)絡(luò)藥理學(xué)方法揭示了丹參山楂組分配伍抗動(dòng)脈粥樣硬化的作用機(jī)制，為深入了解其藥效物質(zhì)基礎(chǔ)和作用靶點(diǎn)提供了重要依據(jù)。本研究也為其他中藥組分配伍的研究提供了新的思路和方法。ThisstudyrevealedtheantiatherosclerosismechanismofSalviamiltiorrhizahawthorncombinationthroughnetworkpharmacologymethod,whichprovidedanimportantbasisforin-depthunderstandingofthematerialbasisandactiontargetofitsefficacy.ThisstudyalsoprovidesnewideasandmethodsforthestudyofcompatibilityofothertraditionalChinesemedicinecomponents.四、討論Discussion網(wǎng)絡(luò)藥理學(xué)作為一種新興的研究方法，為中藥復(fù)方的作用機(jī)制研究提供了新的視角和途徑。本研究以丹參山楂組分配伍為研究對(duì)象，深入探討了其抗動(dòng)脈粥樣硬化的作用機(jī)制，為傳統(tǒng)中藥的現(xiàn)代化研究和臨床應(yīng)用提供了有力的科學(xué)依據(jù)。Networkpharmacology,asanemergingresearchmethod,providesanewperspectiveandapproachforthestudyofthemechanismofactionoftraditionalChinesemedicineformulas.ThisstudytookSalviamiltiorrhizaandHawthornastheresearchobject,deeplydiscusseditsantiatherosclerosismechanism,andprovidedastrongscientificbasisforthemodernizationresearchandclinicalapplicationoftraditionalChinesemedicine.丹參山楂組分配伍抗動(dòng)脈粥樣硬化的作用機(jī)制是多方面的。通過網(wǎng)絡(luò)藥理學(xué)分析，我們發(fā)現(xiàn)該組分配伍中的多種活性成分能夠作用于多個(gè)靶點(diǎn)，進(jìn)而調(diào)節(jié)多條與動(dòng)脈粥樣硬化相關(guān)的信號(hào)通路。這種多成分、多靶點(diǎn)、多通路的作用方式，體現(xiàn)了中藥復(fù)方的整體性和協(xié)同性，也是中藥復(fù)方治療復(fù)雜疾病的優(yōu)勢所在。TheantiatherosclerosismechanismofSalviamiltiorrhizahawthorncombinationismultifaceted.Throughnetworkpharmacologyanalysis,wefoundthatmultipleactiveingredientsinthisgroupcanactonmultipletargets,therebyregulatingmultipleatheroscleroticrelatedsignalpathways.Thismulti-component,multi-target,andmultipathwaymodeofactionreflectstheintegrityandsynergyoftraditionalChinesemedicineformulas,andisalsotheadvantageoftraditionalChinesemedicineformulasintreatingcomplexdiseases.在抗動(dòng)脈粥樣硬化的作用機(jī)制中，丹參山楂組分配伍的活性成分主要通過抗炎、抗氧化、調(diào)節(jié)血脂代謝等途徑發(fā)揮作用。這些作用機(jī)制的揭示，不僅有助于我們深入理解丹參山楂組分配伍抗動(dòng)脈粥樣硬化的作用機(jī)理，也為其他中藥復(fù)方的研究提供了有益的參考。Inthemechanismofantiatherosclerosis,theactiveingredientsofSalviamiltiorrhizahawthornmainlyplayarolethroughanti-inflammatory,antioxidant,regulationoflipidmetabolismandotherways.TherevelationofthesemechanismswillnotonlyhelpustounderstandthemechanismofantiatherosclerosisofDanshenandHawthorncombination,butalsoprovideausefulreferencefortheresearchofothertraditionalChinesemedicineprescriptions.當(dāng)然，本研究還存在一定的局限性。例如，網(wǎng)絡(luò)藥理學(xué)分析雖然能夠預(yù)測藥物與靶點(diǎn)之間的相互作用，但無法完全替代實(shí)驗(yàn)驗(yàn)證。因此，在未來的研究中，我們還需要通過實(shí)驗(yàn)驗(yàn)證來進(jìn)一步確認(rèn)網(wǎng)絡(luò)藥理學(xué)分析的結(jié)果。Ofcourse,thisstudystillhascertainlimitations.Forexample,althoughnetworkpharmacologyanalysiscanpredicttheinteractionbetweendrugsandtargets,itcannotcompletelyreplaceexperimentalvalidation.Therefore,infutureresearch,weneedtofurtherconfirmtheresultsofnetworkpharmacologyanalysisthroughexperimentalverification.本研究通過網(wǎng)絡(luò)藥理學(xué)分析，初步揭示了丹參山楂組分配伍抗動(dòng)脈粥樣硬化的作用機(jī)制。這些發(fā)現(xiàn)不僅有助于我們深入理解中藥復(fù)方的作用機(jī)理，也為中藥復(fù)方的現(xiàn)代化研究和臨床應(yīng)用提供了新的思路和方法。未來，我們將繼續(xù)深入研究丹參山楂組分配伍的作用機(jī)制，以期為其臨床應(yīng)用提供更加科學(xué)、有效的支持。Throughnetworkpharmacologyanalysis,thisstudypreliminarilyrevealedtheantiatherosclerosismechanismofSalviamiltiorrhizaandHawthorncombination.ThesefindingsnotonlyhelpustodeeplyunderstandthemechanismofactionoftraditionalChinesemedicineformulas,butalsoprovidenewideasandmethodsforthemodernizationresearchandclinicalapplicationoftraditionalChinesemedicineformulas.Inthefuture,wewillcontinuetoconductin-depthresearchonthemechanismofactionofthecompatibilityofDanshenandHawthorncomponents,inordertoprovidemorescientificandeffectivesupportfortheirclinicalapplications.五、結(jié)論Conclusion本研究通過網(wǎng)絡(luò)藥理學(xué)的方法，對(duì)丹參山楂組分配伍抗動(dòng)脈粥樣硬化的作用機(jī)制進(jìn)行了深入探究。通過對(duì)丹參和山楂的活性成分進(jìn)行篩選和網(wǎng)絡(luò)構(gòu)建，我們發(fā)現(xiàn)了多個(gè)關(guān)鍵靶點(diǎn)和通路，這些靶點(diǎn)和通路在動(dòng)脈粥樣硬化的發(fā)生和發(fā)展過程中起著重要作用。Inthisstudy,themechanismofantiatherosclerosiseffectofSalviamiltiorrhizahawthorncombinationwasdeeplyexploredthroughnetworkpharmacology.ThroughscreeningandnetworkconstructionofactivecomponentsofSalviamiltiorrhizaandhawthorn,wefoundseveralkeytargetsandpathways,whichplayanimportantroleintheoccurrenceanddevelopmentofatherosclerosis.我們的研究結(jié)果顯示，丹參山楂組分配伍能夠通過調(diào)控炎癥反應(yīng)、改善脂質(zhì)代謝、抗氧化應(yīng)激等多個(gè)方面來發(fā)揮抗動(dòng)脈粥樣硬化的作用。這些發(fā)現(xiàn)不僅為丹參山楂組分配伍在抗動(dòng)脈粥樣硬化方面的應(yīng)用提供了理論基礎(chǔ)，也為進(jìn)一步的藥物研發(fā)和治療策略提供了新的思路。Ourresearchresultsshowthatthecompatibilityofsalviamiltiorrhizaandhawthorncomponentscanplayanantiatherosclerosisrolebyregulatinginflammatoryresponse,improvinglipidmetabolism,antioxidantstressandotheraspects.Thesefindingsnotonlyprovideatheoreticalbasisfortheapplicationofsalviamiltiorrhizaandhawthorncombinationinantiatherosclerosis,butalsoprovidenewideasforfurtherdrugdevelopmentandtreatmentstrategies.然而，本研究仍存在一定的局限性。我們的研究主要基于網(wǎng)絡(luò)藥理學(xué)分析，雖然能夠預(yù)測藥物與靶點(diǎn)之間的相互作用，但仍需進(jìn)一步通過實(shí)驗(yàn)驗(yàn)證其實(shí)際效果。我們的研究主要關(guān)注了丹參和山楂的活性成分，但對(duì)于其他可能存在的輔助成分或相互作用尚未進(jìn)行深入探討。However,thisstudystillhascertainlimitations.Ourresearchismainlybasedonnetworkpharmacologyanalysis.Althoughitcanpredicttheinteractionbetweendrugsandtargets,furtherexperimentalverificationofitsactualeffectisstillneeded.OurresearchmainlyfocusesontheactiveingredientsofSalviamiltiorrhizaandHawthorn,buttherehasnotbeenin-depthexplorationofotherpossibleauxiliarycomponentsorinteractions.本研究通過網(wǎng)絡(luò)藥理學(xué)分析初步揭示了丹參山楂組分配伍抗動(dòng)脈粥樣硬化的作用機(jī)制，為后續(xù)的實(shí)驗(yàn)驗(yàn)證和藥物研發(fā)提供了重要參考。未來，我們將繼續(xù)深入研究丹參山楂組分配伍的抗動(dòng)脈粥樣硬化作用，以期為防治心血管疾病提供更加有效的藥物和治療策略。ThisstudypreliminarilyrevealedtheantiatherosclerosismechanismofDanshenandHawthorncombinationthroughnetworkpharmacologyanalysis,andprovidedimportantreferenceforsubsequentexperimentalverificationanddrugdevelopment.Inthefuture,wewillcontinuetoconductin-depthresearchontheantiatherosclerosiseffectofthecompatibilityofsalviamiltiorrhizaandhawthorncomponentsinordertoprovidemoreeffectivedrugsandtreatmentstrategiesforthepreventionandtreatmentofcardiovasculardiseases.七、致謝Thanks在完成這篇《基于網(wǎng)絡(luò)藥理學(xué)分析丹參山楂組分配伍抗動(dòng)脈粥樣硬化的作用機(jī)制研究》的文章過程中，我深感學(xué)術(shù)研究的不易，也深感團(tuán)隊(duì)協(xié)作的重要性。在此，我要向所有在我研究過程中給予我?guī)椭椭С值娜吮硎咀钫\摯的感謝。Intheprocessofcompletingthisarticle"ResearchontheMechanismofAntiatherosclerosisEffectofSalviaMiltiorrhizaandHawthornCombinationBasedonNetworkPharmacologyAnalysis",Ideeplyfeltthedifficultyofacademicresearchandtheimportanceofteamwork.Iwouldliketoexpressmysincerestgratitudetoallthosewhohaveprovidedmewithhelpandsupportduringmyresearchprocess.我要感謝我的導(dǎo)師，他/她的悉心指導(dǎo)和無私幫助讓