課題組報(bào)告匯工作匯報(bào)

工作匯報(bào)匯報(bào)人：王銘銘工作匯總1，333系列2，二硫代氨基鈉鹽系列3，開(kāi)鏈系列二硫代氨基鈉鹽系列評(píng)價(jià)挑菌（IMP10株，NDM-1選10株）化合物MIC篩選（單用聯(lián)合用藥，聯(lián)合用藥，MEM,NOTA,化合物10個(gè)）紅細(xì)胞溶血（3個(gè)化合物）細(xì)胞毒（3個(gè)化合物）時(shí)間殺菌曲線鋅離子聯(lián)合用藥酶活性實(shí)驗(yàn)蛋白分子對(duì)接開(kāi)鏈系列挑菌（NDM共20株）化合物MIC篩選（單用聯(lián)合用藥，聯(lián)合用藥,MEM,NOTA,化合物3個(gè)）MIC菌株挑選菌株對(duì)應(yīng)編號(hào)A1EC-13-22B1N5-15-2-1D1KP-13-9A2EC-13-33B2N5-15-2-2D2EC-13-26A3PM-13-36B3N5-15-2-24D3ECL-13-46A4CF-14-50B4N5-15-2-26D4ECL-14-57A5EC-15-3B5N5-15-2-35D5K-15-36A6KP-15-35B6N5-15-2-36D6EC-15-65A7PM-58B7N7-15-50D7KP-15-72A8PM-153B8N5-15-2-52D815-2-84A9KP-113B9N4-14-55D915-2-85A10KP-131B10N5-15-2-62D1015-2-88二硫代氨基鈉鹽聯(lián)合用藥MIC結(jié)果化合物編號(hào)/64kp-13-9EC-13-26ECL-13-46ECL-14-57K-15-36EC-15-65KP-15-7215-2-8415-2-8515-2-8849＜0.03125＜0.0312516＜0.03125＜0.03125＜0.03125＜0.03125＜0.03125＜0.031251650＜0.03125＜0.031250.125＜0.03125＜0.03125＜0.03125＜0.03125＜0.03125＜0.03125165182＞16884161681610384＞1681681616816137＞16＞16＞16＞16＞16＞16＞16＞16＞16＞161400.250.0625＜0.031250.06250.1250.0625＜0.03125＜0.031252＞16142162＞1616＞1616＞168＞16＞1614320.54＜0.03125＜0.03125＜0.03125＜0.03125＜0.03125416146168＞168168161684147＜0.0312518812＜0.03125442化合物編號(hào)/32kp-13-9EC-13-26ECL-13-46ECL-14-57K-15-36EC-15-65KP-15-7215-2-8415-2-8515-2-884940.5＞16822＞1688165020.5＞16842888＞1651164＞1616168168816103164＞1681681616168137＞16＞16＞16＞16＞16＞16＞16＞16＞16＞16140＜0.03125＜0.03125＜0.03125＜0.03125＜0.03125＜0.031250.0625＜0.03125＜0.03125＜0.0312514281＞168881688814340.5＞16882＜0.03125881614684＞16888168881478416888＜0.03125884化合物編號(hào)/64EC-13-22EC-13-33PM-13-36CF-14-50EC-15-3KP-15-35PM-58PM-153KP-113KP-13149＜0.03125＜0.03125＜0.03125＜0.031250.25＜0.03125416＜0.03125＜0.0312550＜0.03125＜0.03125＜0.03125＜0.031252＜0.03125280.25＜0.031255188162＞168161641610316842＞16448416137＞16＞16＞16＞16＞16＞16＞16＞16＞16＞16140＞16＞16＞16＞16＞16＞16＞16＞16＞16＞1614216＞16＞16＞16＞16＞160.25＞16＞16＞16143210.5＜0.0312516142＜0.031252146＞16888＞16881681614784241614218MEM單用20201010802020401020開(kāi)鏈化合物聯(lián)合用藥MIC結(jié)果A系列菌株化合物固定濃度64μg/Ml化合物固定濃度64μg/Ml化合物編號(hào)187198199187198199A1222222A20.1250.1250.1250.1250.1250.125A30.50.50.50.50.51A40.1250.1250.1250.1250.1250.125A5121121A6222222A7444444A8442442A9222222A10222222D系列菌株化合物固定濃度64μg/Ml化合物固定濃度64μg/Ml化合物編號(hào)187198199187198199D1444444D2222222D3222222D40.50.50.50.50.50.5D50.125120.062512D60.250.250.250.1250.1250.125D7110.5111D80.1250.1250.1250.1250.250.125D9212211D100.12510.1250.062510.0625B系列菌株化合物固定濃度64μg/Ml化合物編號(hào)187198199B10.1250.1250.25B20.1250.06250.125B30.1250.06250.0625B40.1250.1250.125B50.1250.06250.0625B60.06250.06250.0625B70.1250.06