Isotodesnitazene-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEIsotodesnitazeneCat.No.:HY-164747CASNo.:2732926-27-9分子式:C??H??N?O分子量:365.51作用靶點:OpioidReceptor作用通路:GPCR/GProtein;NeuronalSignaling儲存方式: 4°C,protectfromlight,storedundernitrogenInsolvent:-80°C,6months;-20°C,1month(protectfromlight,storedundernitrogen)溶解性數(shù)據(jù)體外實驗DMSO:≥100mg/mL(273.59mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.7359mL13.6795mL27.3590mL5mM0.5472mL2.7359mL5.4718mL10mM0.2736mL1.3680mL2.7359mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存方式和期限：-80°C,6months;-20°C,1month(protectfromlight,storedundernitrogen)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。BIOLOGICALACTIVITY生物活性 Isotodesnitazene是一種阿片類物質(zhì)。Isotodesnitazene主要作用于μ-阿片受體(MOR)。Isotodesnitazene對MOR-βarr2和MOR-mini-Gi的EC50分別為34.8nM和142nM。Isotodesnitazene可用于阿片類藥物的研究。IC50&Target μOpioidReceptor/MOR1/2 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemEREFERENCESVandeputteMM,etal.Synthesis,ChemicalCharacterization,andμ-OpioidReceptorActivityAssessmentoftheEmergingGroupof"Nitazene"2-BenzylbenzimidazoleSyntheticOpioids.ACSChemNeurosci.2021Apr7;12(7):1241-1251.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:021-5