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1、Crow Fukase syn drome with cerebralin farcti on 1 casesCrow, Fukase syn drome, cerebralin farctio n1clinical data Female patient, 65 years old, admitted to hospital due to the inconvenience of physical activity on the right side of 1 d 2 a before no incentiveto appear black, dry body skin, the body
2、swelli ng sig ni fica ntly lowerlimbs, amenorrhea,feet numb, had to check liver andkidney functionis not see the exception. 2 mo beforeadmission in our hospital because of chest tightness, difficulty breathing, echocardiography shows pericardial effusi on, ascites and pleural fluids, give symptomati
3、c treatme nt improved, no clear diag no sis. deny the history of hepatitis and tuberculosis. exam in ati on: blood pressure 120/75 mmHg, poor nu tritio n, the body pigme ntati on of the skin, areola, obviously, was a dark black, hairy, stai ned yellow, left lower jaw may touch on a 1.0 cmx 1.0 cm si
4、zeof lymph no des, heart and lung fun cti on is no rmal.Abdome n soft, liver and ribs not palpable, splee n and ribs at 1 cm palpable tendern ess, shifti ng dull ness (-), clubb ingof the nail bed white,pittingedema of both lowerextremities,n eurologicalexam in ati on:con sciousmind,Ian guage and ey
5、e each to freedom of moveme nt, Double Visio n sen sitive optical reflecti on, closed lips turn a bli nd eye muscle, the n asolabial fold symmetry, Shen she cen ter.soft n eck, right side of the limb muscle stre ngth gradeIV,Head MRI: leftlow muscle tone, bilateral biceps, triceps, knee tendon refle
6、x Achilles tendon reflex dimini shed, bilateral Babin ski sig n (+), the distal extremities dull type of pain, and deephypoesthesia.fun duspapilledema.temporal-parietalin farct;EMG: limbs peripheraln erve4ultras ono graphy:space-occupy ing,cha nges; ECG: no rmal ECG; abdo minalsubsta ntive rightin t
7、rahepaticcon sideri ngthe hema ngioma,splee n,splee n;colorDoppler ultraso und of the lower limbs: diffuse plaques, i n line with atherosclerosis ; pul monary CT: right side of thepleura is visible thicke ningdual marki ngs running clear;echocardiography: a small amount of pericardial effusi on;7 of
8、 thyroid fun cti on, no rmal blood, urine and biochemicaltests, prothromb in activity 93%, an ti nu clear an tibodies (-).lumbar pun cture: pressure 160 mmH20 (no rmal). no rmalrouti ne biochemical; cerebrosp inal fluidoligocl onal ban d-positive urine light cha in associated KAP of 183 mg /L (norma
9、l: 0.00 of 50 mg / L,). 1 globulin 4.7 % (normal ran ge: 1.4% 4.1%). blood light chain of LAM 7.1 mg / L (n ormal value: 2.98 6.65 mg / L), blood of the I gA7.1 mg/ L, (no rmal: <6.65 mg / L) whole body bone sea n: left proximal femurabno rmalradioactivein creasedbonemarrow:material well, poor sm
10、ear, stai ning, 60% ofplasma cells. diag no sis:Crow Fukase syn dromewithcerebral in farctio n in the day of admissi on, acute seizure hemaggluti nati onfour immediate defibrase 10U staticpoin ts, the n ext day to give the Sodium Ozagrel 80 mg 2 times / d, static poin t, 10 d, patie nts with the rig
11、ht side of limb muscle strengthwas significantlyrestored, couldwalkin depe nden tlyrequired for discharge to givepred nisone 35 mg / d, oral, 6 mo after the patie nts died.2 Discussion Crow Fukase syndrome is a multi-systemdisease,complex and diverse cli ni calmani festati ons 1 and its diag no stic
12、 criteria: (1) peripheral neuropathy, organ enlargement, endocrine lesions, M albumin, or plasma cell tumor, skin lesions typical cases should be above 5 lesi ons, atypical cases with at least , and the remaining three one beforediag no sis,whichis themost importa nt peripheraln europathy,andabno rm
13、al hypergammaglobuli plexity and diversity of its cli nical mani festati ons, the symptoms in order of appeara nee varies, it is easily missed, misdiagnosedCrow Fukase syndrome is no specifictreatme nt methods, multi-method for the treatme nt of a horm one,immuno suppressiveage nts,chemotherapy,local radiotherapy has alsobee nreportedChin esemedic ine Qi, splee n, kid ney and other prescripti on so that the con diti on be relieved 2.References 1 SHI Yu Zhou Xiao reached practical n eurology lear ning M
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