antipsychoticdrugs學(xué)習(xí)教案

1、會計學(xué)1antipsychoticdrugs第一頁，共26頁。disturbed perceptionsinappropriate emotions & action第1頁/共26頁第二頁，共26頁。第2頁/共26頁第三頁，共26頁。第3頁/共26頁第四頁，共26頁。第4頁/共26頁第五頁，共26頁。第5頁/共26頁第六頁，共26頁。 Phenothiazin 吩噻嗪類吩噻嗪類 chlorpromazine 氯丙嗪氯丙嗪 (wintermine 冬眠冬眠(dngmin)靈靈) 第6頁/共26頁第七頁，共26頁。 Blocking Mesolimbic system and mesoco

2、rtical D2-R More effective for treating positive symptom Substantia nigra- corpus striatum - extrapyramidal effects 錐體外系反應(yīng)錐體外系反應(yīng)(fnyng) Node-funnel - endocrine system action第7頁/共26頁第八頁，共26頁。mechanismsn decrease temperature no matter normal or high temperature n body temperature varies with the envir

3、onment第8頁/共26頁第九頁，共26頁。n autonomic NS effectsn blocking -Rn vasodilatationn “epinephrine reversal”n blocking M-R n atropine-like actionn endocrine system actionn increasing prolactin催乳素催乳素 secretionn inhibiting gonadotropic hormone促性腺激素，促性腺激素，n growth hormone生長激素生長激素(shn chn j s) secretion第9頁/共26頁第十

4、頁，共26頁。n chlorpromazine promethazine pethidinen（氯丙嗪（氯丙嗪 異丙嗪異丙嗪 哌哌替啶）替啶）第10頁/共26頁第十一頁，共26頁。(artane, )第11頁/共26頁第十二頁，共26頁。 tardive dyskinesia 遲發(fā)性運動障礙遲發(fā)性運動障礙 treated by antidopamine drugs (clozapine,氯氮平氯氮平)Neural antagonist severe symdromedrug-induced mind abnormality convulsion驚厥驚厥 and epilepsy癲癇癲癇alle

5、rgic reaction acute hypogranulocytosis (粒細胞減少粒細胞減少(jinsho)癥癥)cardiovascular and endocrine system reactionacute poisoning 急性中毒急性中毒第12頁/共26頁第十三頁，共26頁。du)uclozapine 氯氮平氯氮平第13頁/共26頁第十四頁，共26頁。第14頁/共26頁第十五頁，共26頁。Antimanic drugsnBipolar affective disorder （雙極性情感障礙（雙極性情感障礙(zhng i)）nCyclic manic attacks （往復(fù)性

6、躁狂發(fā)作）（往復(fù)性躁狂發(fā)作）nIn high spirit （情緒高漲）（情緒高漲）nOveractivity （過度活動）（過度活動）nParanoid thoughts （妄想）（妄想）第15頁/共26頁第十六頁，共26頁。Lithium Carbonate （碳酸鋰）（碳酸鋰）Clinical usen Based on the Li+ n treatment for bipolar disorder manic phase particularlyn prophylactic Li may block both manic and depressive第16頁/共26頁第十七頁，共26

7、頁。 Adverse effectsGI tract nausea, vomiting, diarrhea mental confusion, tremor, aphasia 失語癥失語癥, choreoathetosis 舞蹈舞蹈(wdo)癥癥, comaManagement of Li overdosage:peritoneal dialysis腹膜透析腹膜透析or hemodialysisiv NaCl第17頁/共26頁第十八頁，共26頁。第18頁/共26頁第十九頁，共26頁。depressant effect depression: mood elevation, spirit exc

8、itationThe onset of the mood-elevation is slow, 23 weeks第19頁/共26頁第二十頁，共26頁。第20頁/共26頁第二十一頁，共26頁。第21頁/共26頁第二十二頁，共26頁。pressure, arrhythmia, dry mouth, constipation第22頁/共26頁第二十三頁，共26頁。5-HT reuptake inhibitorfluoxetine 氟西汀氟西汀,百憂解百憂解u inhibit 5-HT reuptake selectively u treat depression: improve attention

9、 emotionu adverse effects: GI tract reaction, tremor u risk of life-threatening “serotonin-syndrome” co-administered with MAO inhibitors第23頁/共26頁第二十四頁，共26頁。 MAO inhibitor Phenelzine 苯乙肼苯乙肼 inhibit MAO nonselectively treat mild, moderate depression, also phobic states恐怖恐怖(kngb)狀態(tài)狀態(tài) side effects: orthostatic hypotension, nausea, headache, insomnia