Embelin-Embelic-acid-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEmbelinCat. No.: HY-17473CAS No.: 550-24-3Synonyms: Embelic acid; Emberine; NSC 91874分式: CHO分量: 294.39作靶點(diǎn): IAP作通路: Apoptosis儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 50 mg/mL (169.84

2、mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.3969 mL 16.9843 mL 33.9685 mL5 mM 0.6794 mL 3.3969 mL 6.7937 mL10 mM 0.3397 mL 1.6984 mL 3.3969 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，

3、體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (8.49 mM); Suspended solution; Need ultrasonic2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (8.49 mM); Clear solution1/2 Master of Small Molecule

4、s 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Embelin可滲透細(xì)胞的，有抗癌特性的苯醌化合物。戶(hù)使本產(chǎn)品發(fā)表的科研獻(xiàn) Mol Neurobiol. 2014 Apr;49(2):1087-101.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Siegel C, et al. miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences

5、in the response to cerebralischemia. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11662-7.2. Hu R, et al. Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells. Med Oncol. 2011 Dec;28(4):1584-8.3. Siegelin MD, et al. The XIAP inhibitor Embelin enhances TRAIL-mediated apo

6、ptosis in malignant glioma cells by down-regulation of theshort isoform of FLIP. Neurochem Int. 2009 Nov;55(6):423-30.4. Kalyan Kumar G, et al. Embelin reduces cutaneous TNF- level and ameliorates skin edema in acute and chronic model of skininflammation in mice. Eur J Pharmacol. 2011 Jul 15;662(1-3

7、):63-9.5. Kumar G K, et al. Embelin ameliorates dextran sodium sulfate-induced colitis in mice. Int Immunopharmacol. 2011 Jun;11(6):724-31.6. Xue Z, et al. Embelin suppresses dendritic cell functions and limits autoimmune encephalomyelitis through the TGF-/-catenin andSTAT3 signaling pathways. Mol Neurobiol. 2014 Apr;49(2):1087-101.McePdfHeightCaution: Product has not been fully validated for medical applications.For research