Propyl-pyrazole-triol-PPT-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPropyl pyrazole triolCat. No.: HY-100689CAS No.: 263717-53-9Synonyms: PPT分式: CHNO分量: 386.44作靶點(diǎn): Estrogen Receptor/ERR作通路: Others儲存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (258.77 mM)*

2、means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.5877 mL 12.9386 mL 25.8772 mL5 mM 0.5175 mL 2.5877 mL 5.1754 mL10 mM 0.2588 mL 1.2939 mL 2.5877 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作

3、液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 10 mg/mL (25.88 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 10 mg/mL (25.88 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Ma

4、ster of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 10 mg/mL (25.88 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Propyl pyrazole triol (PPT)種雌激素受體 (ER) 激動劑。Propyl pyrazole triol (PPT) 對 ER 的相對結(jié)合親和 (ER: 49%)是雌激素受體 (ER: 0.12%) 的 410 倍 1。IC50 & Target Estrogen receptor alpha 1體外研究 The EC50 of Propyl py

5、razole triol for the ER-dependent response is 140 pM in ER-U2OS-Luc cells 1.REFERENCES1. /pubmed/18644836/2. Stauffer SR, et al. Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem.2000 Dec 28;43(26):4934-47.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-