PF-4840154 _TRP Channel Agonist - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPF-4840154Cat. No.: HY-18779CAS No.: 1332708-14-1分式: CHNO分量: 466.62作靶點: TRP Channel作通路: Membrane Transporter/Ion Channel; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 5

2、0 mg/mL (107.15 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.1431 mL 10.7154 mL 21.4307 mL5 mM 0.4286 mL 2.1431 mL 4.2861 mL10 mM 0.2143 mL 1.0715 mL 2.1431 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液

3、，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.36 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.36 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubil

4、ity: 2.5 mg/mL (5.36 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 PF-4840154有效，選擇性的和 TrpA1 通道激動劑， EC50分別為97和23nM。IC50 & Target IC50: 97 nM (rTrpA1), 23 nM (hTrpA1) 1REFERENCES1. Ryckmans T, et al. Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel.Bioorg Med Chem Lett. 2011 Aug 15;21(16):4857-4859.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;