TCS-PIM-1-1-SC-204330-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETCS PIM-1 1Cat. No.: HY-18086CAS No.: 491871-58-0Synonyms: SC 204330分式: CHBrNO分量: 367.2作靶點(diǎn): Pim作通路: JAK/STAT Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 52 mg/mL (141.61 mM)* m

2、eans soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.7233 mL 13.6166 mL 27.2331 mL5 mM 0.5447 mL 2.7233 mL 5.4466 mL10 mM 0.2723 mL 1.3617 mL 2.7233 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實(shí)驗(yàn) TCS PIM-1 1 is dissolved in 0.5% DMSO2.BIOLOGICAL ACTIVITY物活性 T

3、CS PIM-1 1 (SC 204330)ATP競爭性Pim-1激酶抑制劑，IC50為50nM，對Pim-2和MEK1/MEK2的抑制性較。1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Clin Res Hepatol Gastroenterol. 2018 Sep;42(4):382-386. J Cent South Univ. 2018, 43(5): 481-489.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Ch

4、eney IW, et al. Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg MedChem Lett. 2007 Mar 15;17(6):1679-83.2. Shen Y, et al. Pim-1 inhibitor attenuates trinitrobenzene sulphonic acid induced colitis in the mice. Clin Res Hepatol Gastroenterol. 2018Sep;42(4):382-386.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax