Tauroursodeoxycholate-dihydrate-TUDCA-dihydrate-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETauroursodeoxycholate dihydrateCat. No.: HY-19696BCAS No.: 117609-50-4Synonyms: TUDCA dihydrate; UR 906 dihydrate; Taurolite dihydrate分式: CHNOS分量: 535.73作靶點: ERK; Caspase; Apoptosis作通路: MAPK/ERK Pathway; Stem Cell/Wnt; Apoptosis

2、儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 83.33 mg/mL (155.54 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.8666 mL 9.3331 mL 18.6661 mL5 mM 0.3733 mL 1.8666 mL 3.7332 mL10 mM 0.1867 mL 0.9333 mL 1.8666 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑

3、配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (3.88 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline

4、)Solubility: 2.08 mg/mL (3.88 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.08 mg/mL (3.88 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Tauroursodeoxycholate dihydrate (TUDCA dihydrate; UR 906 dihydrate; Taurolite dihydrate)種內(nèi)質(zhì)應(yīng)激抑制劑

5、。Tauroursodeoxycholate 顯著降低凋亡分如 caspase-3 和 caspase-12 表達(dá)。Tauroursodeoxycholate 也抑制 ERK 1 2。IC50 & Target ERK 1Caspase-3, Caspase-12 2戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Br J Pharmacol. 2019 Jul;176(13):2162-2178. Biochem Pharmacol. 2018 May 24;154:278-292. Sci Rep. 2017 Aug 30;7(1):9967. Food Chem Toxicol. 2018 Jul 14;120

6、:253-260. Fundam Clin Pharmacol. 2018 Aug;32(4):363-377.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Kim SY, et al. Tauroursodeoxycholate (TUDCA) inhibits neointimal hyperplasia by suppression of ERK viaPKC-mediated MKP-1induction. Cardiovasc Res. 2011 Nov 1;92(2):307-16.2.

7、Qin Y, et al. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. Eur J Vasc Endovasc Surg. 2017 Mar;53(3):337-345.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use