Itraconazole-R51211-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEItraconazoleCat. No.: HY-17514CAS No.: 84625-61-6Synonyms: R51211分式: CHClNO分量: 705.63作靶點(diǎn): Fungal; Autophagy作通路: Anti-infection; Autophagy儲(chǔ)存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)

2、溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 7.3 mg/mL (10.35 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.4172 mL 7.0859 mL 14.1717 mL5 mM 0.2834 mL 1.4172 mL 2.8343 mL10 mM 0.1417 mL 0.7086 mL 1.4172 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Itraco

3、nazole是抗真菌劑。戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Med Mycol. 2018 Jun 1;56(4):452-457.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESee more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Kim, J., et al., Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Canc

4、er Cell, 2010.17(4): p. 388-99.2. Chong, C.R., et al., Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem Biol, 2007. 2(4): p. 263-70.3. Shi, W., et al., Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation,

5、vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling. J Med Chem, 2011. 54(20): p. 7363-74.4. Olkkola, K.T., J.T. Backman, and P.J. Neuvonen, Midazolam should be avoided in patients receiving the systemic antimycoticsketoconazole or itraconazole. Clinical Pharmacology & Therapeutics, 1994. 55(5): p. 481-485.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;