Pafuramidine-DB289-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPafuramidineCat. No.: HY-14932CAS No.: 186953-56-0Synonyms: DB289分式: CHNO分量: 364.4作靶點(diǎn): Parasite作通路: Anti-infection儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 33.33 mg/mL (91.47 mM; Need

2、 ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.86 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (6.86 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Pafuramidine (DB289)服物相容性的furamidine原藥，臨床上具有抗肺囊肺

3、炎活性。 Molecules. 2018 May 16;23(5). pii: E1195.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Lanteri CA, Trumpower BL, Tidwell RR, DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharomyces cerevisiae.Antimicrob Agents Chemother. 2004 Oct;48(10):3968-74

4、.2. Midgley I, Fitzpatrick K, Taylor LM, Pharmacokinetics and metabolism of the prodrug DB289 (2,5-bis4-(N-methoxyamidino)phenylfuranmonomaleate) in rat and monkey and its conversion to the antiprotozoal/antifungal drug DB75 (2,5-bis(4-guanylphenyl)furan d3. Sturk LM, Brock JL, Bagnell CR, Distribut

5、ion and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75)and its N-methoxy prodrug DB289 in murine brain tissue. Acta Trop. 2004 Jul;91(2):131-43.4. In vitro inhibitory activity against Trypanosoma brucei rhodesiense - BioAssay Summary.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-