BMS-1001-hydrochloride-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBMS-1001 hydrochlorideCat. No.: HY-120635CAS No.: 2113650-04-5分式: CHClNO分量: 631.11作靶點(diǎn): PD-1/PD-L1作通路: Immunology/Inflammation儲(chǔ)存式: Please store the product under the recommended conditions inthe COA.溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 12.5 mg/mL (1

2、9.81 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.5845 mL 7.9225 mL 15.8451 mL5 mM 0.3169 mL 1.5845 mL 3.1690 mL10 mM 0.1585 mL 0.7923 mL 1.5845 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢?qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄

3、的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 1.25 mg/mL (1.98 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 1.25 mg/mL (1.98 mM); Clear solutionBIOLOGICAL ACTIVITY物活性BMS-1001 hydrochloride具有服活性的、 PD-

4、L1/PD-1 免疫檢查點(diǎn)的抑制劑。BMS-10011/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEhydrochloride 具有細(xì)胞毒性低的特點(diǎn)。IC50 & Target PD-L1/PD-1 1.體外研究 BMS-1001 binds to human PD-L1 and blocks its interaction with PD-1. BMS-1001 presents low toxicitytowards tested cell lines and block the interaction of soluble PD-L1 w

5、ith the cell surface-expressed PD-1.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes 1.REFERENCES1. Skalniak L, et al. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.Oncotarget. 2017 Aug 7;8(42):72167-72181.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0