SNDX-5613-DataSheet-生命科學(xué)試劑-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemESNDX-5613Cat.No.:HY-136175CASNo.:2169919-21-3分?式:C??H??FN?O?S分?量:630.82作?靶點(diǎn):EpigeneticReaderDomain作?通路:Epigenetics儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:41.67mg/mL(66.06mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.5852mL7.9262mL15.8524mL5mM0.3170mL1.5852mL3.1705mL10mM0.1585mL0.7926mL1.5852mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存?式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案，配制前請(qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥4.17mg/mL(6.61mM);Clearsolution2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥4.17mg/mL(6.61mM);Clearsolution3.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥4.17mg/mL(6.61mM);Clearsolution1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性SNDX-5613?種有效的特異性Menin-MLL抑制劑，結(jié)合Ki為0.149nM，細(xì)胞實(shí)驗(yàn)中，抑制Menin-MLL的IC50為10-20nM[1]。SNDX-5613可?于MLL因重排的急性??病研究，包括急性淋巴細(xì)胞??病(ALL)和急性髓細(xì)胞??病(AML)[1]。IC50&TargetMenin-MLL[1]體內(nèi)研究SNDX-5613showsinvivoplasmaIC50of53nM.SNDX-5613treatmentprovidessignificantsurvivalbenefitandleukemiccontrolinaggressiveMOLM-13disseminatedxenografts[1].REFERENCES[1].Adrug,SNDX-5613,totreatacuteleukemiawithaKMT2AtranslocationoranNPM1mutationthathascomeback(relapsed)orhasnotgottenbetterwithtreatment(refractory).McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021