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CholesteatomaShankaiYinProfDeptofOtolaryngology,thesixthhospitalaffiliatedtoShanghaijiaotonguniversityOtolaryngologyinstituteatShanghaijiaotonguniversityCholesteatomaShankaiYinProEpidemiologyExactprevalenceisunknownIncidenceestimatedbetween3and12.6per100,000EpidemiologyExactprevalenceiClassificationCongenitalAcquiredPrimaryacquired(retractionpocket)SecondaryacquiredClassificationCongenitalPathogenesisCongenitalArisefromembryonalrestsofepithelialcellsLocation(petrouspyramid,mastoidandmiddleearcleft)LevensoncriteriaWhitemassmedialtonormalTMNormalparsflaccidaandtensaNohistoryofotorrheaorperforationsNopriorotologicproceduresPriorboutsofotitismedianotgroundsforexclusionPathogenesisCongenitalTheories
“Acquired”inclusiontheory -TosEpidermalresttheory-TeedMichaelTheories“Acquired”inclusiCongenitalcholesteatomaCongenitalcholesteatomaPrimaryacquiredEustachiantubedysfunctionPooraerationoftheepitympanicspaceRetractionoftheparsflaccidaNormalmigratorypatternalteredAccumulationofkeratin,enlargementofsacPrimaryacquiredPrimaryacquiredcholesteatomaPrimaryacquiredcholesteatomaSecondaryacquiredImplantation–surgery,foreignbody,blastinjuryMetaplasia–transformationofcuboidalepitheliumtosquamousepitheliumfromchronicinfectionInvasion/Migration–medialmigrationalongpermanentperforationofTMPapillaryingrowth–intactparsflaccida,inflammationinPrussack’sspace,breakinthebasalmembrane,cordsofepitheliummigrateinwardSecondaryacquired上海交通大學(xué)耳鼻咽喉科學(xué)英文版課件cholesteatomaClinicalmanifestationsCommonPainlessotorrheaRefractory/recurrentearinfectionsConductivehearinglossUncommonVertigo/SensorineuralFacialnerveparalysisCNSinfectionsBrainherniation/CSFleakPneumocephalusClinicalmanifestationsCommonhistoryPhysicalExaminationOtomicroscopyPosterosuperiorretractionpocketwithsquamGranulationfromdiseasedboneAuralpolypsPneumaticotoscopy–positivefistularesponsesuggestserosionintolabyrinthCulturesshouldbeobtainedininfectedearsDiagnosishistoryDiagnosisAudiologyusuallyconductiveloss,mayvarygreatly;confirmwithtuningforksImaging
CTtemporalbone–definitelyobtainforrevisioncases,complicationsofchronicsuppurativeotitismedia,sensorineuralhearingloss,vestibularsymptoms,othercomplicationsofcholesteatomaAudiologyImagingPurposeDiagnosisDeterminingextentRiskassessmentModalitiesPlainfilmComputedtomographyscansMagneticResonanceimagingImagingPurpose
GoalsofCTImagingMiddleearventilationOssiculardestructionEpitympanumaccessMastoidcortexTegmenintegrityLabyrinthinvolvementFacialnerveinvolvementSurgicalchangesGoalsofCTImagingMiddleear上海交通大學(xué)耳鼻咽喉科學(xué)英文版課件cholesteatoma上海交通大學(xué)耳鼻咽喉科學(xué)英文版課件cholesteatoma上海交通大學(xué)耳鼻咽喉科學(xué)英文版課件cholesteatomaCTdisadvantagesGranulationtissuevs.cholesteatomaSpecificsofttissueproblemsDuralinvolvementAbscessBrainherniationLabyrinthinvolvementSigmoidsinusthrombosisMRIneededCTdisadvantagesGranulationtiMRImagingHypointenseonT1IsointensetobrainIntermediateonT2NonenhancingGranulationtissuedoesenhanceRecurrencedetectionLesions>2mm90%sensitive,100%specificityMRImagingHypointenseonT1T2DelayedcontrastT1T2DelayedcontrastT1DifferentialDiagnosisChronicserousotitismediaJugulotympanicparagangliomasCholesterolgranulomasNeurofibromasHemangiomasArachnoidcystJugularbulbanomaliesTympanosclerosisencephaloceleDifferentialDiagnosisChronicTreatmentCreatea“dryandsafe”ear
TreatmentCreatea“dryandsaf
Non-surgicalTreattheInfection–FloxinOticDropsDecreasetheinflammation–TopicalsteroidsDebridementoftheexternalcanalNon-surgicalTreattheInfectiSurgicalAtticotomyRadicalMastoidectomyBondyModifiedRadical(Canalwalldown)mastoidectomyTympanoplastyandcanalwallupmastoidectomySurgicalAtticotomyPrognosisResidualorrecurrentcholesteatomaover5years–15to40%Reportedtobeupto67%inthepediatricpopulationClosefollow-up
Regularexaminationsneeded-6monthsPrognosisResidualorrecurrentComplicationsDuraltear-CSFleakFistulaofthehorizontalsemicircularcanal(vertigo)–Upto10%FacialnerveinjuryInjurytothesigmoidsinus/jugularbulbOtiticHydrocephalusHearingloss30%haveconductivelosspre-operativelyPostoperatively,anadditional30%haveworseningoronsetofhearinglossduetoextentofdiseaseInfection–Meningitis,Abscess,lateralsinusthrombosis–Upto1%ComplicationsDuraltear-CSFPredisposingfactorsVirulentorganismsCholesteatomaandboneerosionPresenceofacongenitaldehiscence(e.g.dehiscentfacialcanal)orapreformedpathway(e.g.skullbasefracture)Obstructionofdrainagee.g.byapolyp.LowresistanceofthepatientPredisposingfactorsVirulentoPathwaysofinfectionThecommonestwayforextensionofinfectionisbyboneerosionduetoacholesteatoma.Vascularextension(retrogradethrombophlebitis).Extensionalongpreformedpathwaysas–Congenitaldehiscences,fracturelines,roundwindowmembrane,thelabyrinth,–Dehiscencesduetoprevioussurgery.PathwaysofinfectionThecommoClassificationCranialcomplicationsExtra-cranialcomplicationsIntra-cranialcomplicationsClassificationCranialcomplicaCranialcomplicationsAcutemastoiditisandmastoidabscesses(mostcommoncomplication).Petrositis.Labyrinthitis.Facialparalysis.OsteomyelitisofthetemporalboneCranialcomplicationsAcutemasExtra-cranialcomplicationsExternalotitisCervicallymphadenitisRetropharyngealParapharyngealabscessesExtra-cranialcomplicationsExtIntracranialcomplicationsExtraduralabscess(commonestintracranialcomplication).Subduralabscess.Meningitis.Brainabscess:Temporallobeabscess.Cerebellarabscess.Lateralsinusthrombosis.Otitichydrocephalus.IntracranialcomplicationsExtPotentiallylifethreateningSuppurativeotorrhea,chronicheadache,pain,fever–impendingintracranialcomplicationMentalstatuschanges,nuchalrigidity,cranialneuropathiesrequireneurosurgicalconsultPotentiallylifethreatening上海交通大學(xué)耳鼻咽喉科學(xué)英文版課件cholesteatoma上海交通大學(xué)耳鼻咽喉科學(xué)英文版課件cholesteatomaBrainAbscessBrainAbscessQuestions?Questions?CholesteatomaShankaiYinProfDeptofOtolaryngology,thesixthhospitalaffiliatedtoShanghaijiaotonguniversityOtolaryngologyinstituteatShanghaijiaotonguniversityCholesteatomaShankaiYinProEpidemiologyExactprevalenceisunknownIncidenceestimatedbetween3and12.6per100,000EpidemiologyExactprevalenceiClassificationCongenitalAcquiredPrimaryacquired(retractionpocket)SecondaryacquiredClassificationCongenitalPathogenesisCongenitalArisefromembryonalrestsofepithelialcellsLocation(petrouspyramid,mastoidandmiddleearcleft)LevensoncriteriaWhitemassmedialtonormalTMNormalparsflaccidaandtensaNohistoryofotorrheaorperforationsNopriorotologicproceduresPriorboutsofotitismedianotgroundsforexclusionPathogenesisCongenitalTheories
“Acquired”inclusiontheory -TosEpidermalresttheory-TeedMichaelTheories“Acquired”inclusiCongenitalcholesteatomaCongenitalcholesteatomaPrimaryacquiredEustachiantubedysfunctionPooraerationoftheepitympanicspaceRetractionoftheparsflaccidaNormalmigratorypatternalteredAccumulationofkeratin,enlargementofsacPrimaryacquiredPrimaryacquiredcholesteatomaPrimaryacquiredcholesteatomaSecondaryacquiredImplantation–surgery,foreignbody,blastinjuryMetaplasia–transformationofcuboidalepitheliumtosquamousepitheliumfromchronicinfectionInvasion/Migration–medialmigrationalongpermanentperforationofTMPapillaryingrowth–intactparsflaccida,inflammationinPrussack’sspace,breakinthebasalmembrane,cordsofepitheliummigrateinwardSecondaryacquired上海交通大學(xué)耳鼻咽喉科學(xué)英文版課件cholesteatomaClinicalmanifestationsCommonPainlessotorrheaRefractory/recurrentearinfectionsConductivehearinglossUncommonVertigo/SensorineuralFacialnerveparalysisCNSinfectionsBrainherniation/CSFleakPneumocephalusClinicalmanifestationsCommonhistoryPhysicalExaminationOtomicroscopyPosterosuperiorretractionpocketwithsquamGranulationfromdiseasedboneAuralpolypsPneumaticotoscopy–positivefistularesponsesuggestserosionintolabyrinthCulturesshouldbeobtainedininfectedearsDiagnosishistoryDiagnosisAudiologyusuallyconductiveloss,mayvarygreatly;confirmwithtuningforksImaging
CTtemporalbone–definitelyobtainforrevisioncases,complicationsofchronicsuppurativeotitismedia,sensorineuralhearingloss,vestibularsymptoms,othercomplicationsofcholesteatomaAudiologyImagingPurposeDiagnosisDeterminingextentRiskassessmentModalitiesPlainfilmComputedtomographyscansMagneticResonanceimagingImagingPurpose
GoalsofCTImagingMiddleearventilationOssiculardestructionEpitympanumaccessMastoidcortexTegmenintegrityLabyrinthinvolvementFacialnerveinvolvementSurgicalchangesGoalsofCTImagingMiddleear上海交通大學(xué)耳鼻咽喉科學(xué)英文版課件cholesteatoma上海交通大學(xué)耳鼻咽喉科學(xué)英文版課件cholesteatoma上海交通大學(xué)耳鼻咽喉科學(xué)英文版課件cholesteatomaCTdisadvantagesGranulationtissuevs.cholesteatomaSpecificsofttissueproblemsDuralinvolvementAbscessBrainherniationLabyrinthinvolvementSigmoidsinusthrombosisMRIneededCTdisadvantagesGranulationtiMRImagingHypointenseonT1IsointensetobrainIntermediateonT2NonenhancingGranulationtissuedoesenhanceRecurrencedetectionLesions>2mm90%sensitive,100%specificityMRImagingHypointenseonT1T2DelayedcontrastT1T2DelayedcontrastT1DifferentialDiagnosisChronicserousotitismediaJugulotympanicparagangliomasCholesterolgranulomasNeurofibromasHemangiomasArachnoidcystJugularbulbanomaliesTympanosclerosisencephaloceleDifferentialDiagnosisChronicTreatmentCreatea“dryandsafe”ear
TreatmentCreatea“dryandsaf
Non-surgicalTreattheInfection–FloxinOticDropsDecreasetheinflammation–TopicalsteroidsDebridementoftheexternalcanalNon-surgicalTreattheInfectiSurgicalAtticotomyRadicalMastoidectomyBondyModifiedRadical(Canalwalldown)mastoidectomyTympanoplastyandcanalwallupmastoidectomySurgicalAtticotomyPrognosisResidualorrecurrentcholesteatomaover5years–15to40%Reportedtobeupto67%inthepediatricpopulationClosefollow-up
Regularexaminationsneeded-6monthsPrognosisResidualorrecurrentComplicationsDuraltear-CSFleakFistulaofthehorizontalsemicircularcanal(vertigo)–Upto10%FacialnerveinjuryInjurytothesigmoidsinus/jugularbulbOtiticHydrocephalusHearingloss30%haveconductivelosspre-operativelyPostoperatively,anadditional30%haveworseningoronsetofhearinglossduetoextentofdiseaseInfection–Meningitis,Abscess,lateralsinusthrombosis–Upto1%ComplicationsDuraltear-CSFPredisposingfactorsVirulentorganismsCholesteatomaandboneerosionPresenceofacongenitaldehiscence(e.g.dehiscentfacialcanal)orapreformedpathway(e.g.skullbasefracture)Obstructionofdrainagee.g.byapolyp.LowresistanceofthepatientPredisposingfactorsVirulentoPathwaysofinfectionThecommonestwayforextensionofinfectionisbyboneerosionduetoacholesteatoma.Vascularextension(retrograde
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