DDR2-IN-1-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEDDR2-IN-1Cat.No.:HY-112545CASNo.:1573053-23-2分?式:C??H??ClN?O?分?量:526.03作?靶點:DiscoidinDomainReceptor作?通路:ProteinTyrosineKinase/RTK儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實驗DMSO:250mg/mL(475.26mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.9010mL9.5052mL19.0103mL5mM0.3802mL1.9010mL3.8021mL10mM0.1901mL0.9505mL1.9010mL體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(3.95mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.08mg/mL(3.95mM);Suspendedsolution;NeedultrasonicBIOLOGICALACTIVITY1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE?物活性DDR2-IN-1?種有效的DDR2抑制劑，IC50為26nM。DDR2-IN-1，化合物129，可?于?關節(jié)炎研究。IC50&TargetIC50:26nM(DDR2)[1]REFERENCES[1].MargaritaWucherer-Plietker,etal.Inhibiteursdeddr2pourletraitementdel'arthrose.PatentWO2014032755A2.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-53