抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件

李道洋留美學(xué)者國家一級心理咨詢師Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL李道洋留美學(xué)者1抑郁癥的產(chǎn)生原理Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL抑郁癥的產(chǎn)生原理2五羥色胺(5-TH)去甲腎上腺素(NE多巴胺(DA)Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL五羥色胺(5-TH)3五羥色胺(5-H)開高感遲鈍心培穩(wěn)焦慮五羥色胺(5-TH)感敏感抑郁焦慮性抑郁Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL五羥色胺(5-H)開高感遲鈍心培穩(wěn)4a11--覺醒-精力增加NE升高a21改善認知β↑抗抑郁意志活動1〓→思睡一精力下降冖→減退NE降低2「→認知下降一→思維遲緩阝↓-情感低落阻滯性抑郁Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyLa11--覺醒-精力增加5前額皮質(zhì)D1受體↑認知改善DA高〈伏隔核口1受體↑增加快感紋狀體D2受體↑精神運動靈活前額皮質(zhì)D受體!→→認知下降思維遲緩DA傌伏嗝核D1受體!一快感缺失→情感低落紋狀體D2受體精神運動哪意志活動減退遲鈍阻滯性抑郁Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL前額皮質(zhì)D1受體↑認知改善65-TH濃度低下焦慮性抑郁NE濃度低下(主要阻滯性抑郁DA濃度低下(次要Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL5-TH濃度低下焦慮性抑郁7ssR|s類藥物在臨床治療中的運用Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyLssR|s類藥物在臨床治療中的運用8ssR|制5TH再攝取門控系統(tǒng)→突觸間隙5T濃度升高情感遲鈍治療焦慮性抑郁治療焦慮障礙注:強迫癥、創(chuàng)傷后應(yīng)激驚強恐創(chuàng)傷障礙產(chǎn)生的原因亦包括了性障追怖后應(yīng)激障情感的高度敏感焦礙癥癥慮Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyLssR|制5TH再攝取門控系統(tǒng)→突觸間隙5T濃度升高9sSRs類藥物的副反應(yīng)(三高、三低)Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyLsSRs類藥物的副反應(yīng)(三高、三低)10抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件11抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件12抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件13抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件14抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件15抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件16抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件17抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件18抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件19抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件20抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件21抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件22抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件23抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件24抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件25抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件26抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件27抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件28抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件29抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件30抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件31抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件32抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件33抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件34抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件35抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件36抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件37抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件38抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件39抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件40抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件41抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件42抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件43抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件44抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件45抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件46抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件47抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件48抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件49李道洋留美學(xué)者國家一級心理咨詢師Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL李道洋留美學(xué)者50抑郁癥的產(chǎn)生原理Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL抑郁癥的產(chǎn)生原理51五羥色胺(5-TH)去甲腎上腺素(NE多巴胺(DA)Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL五羥色胺(5-TH)52五羥色胺(5-H)開高感遲鈍心培穩(wěn)焦慮五羥色胺(5-TH)感敏感抑郁焦慮性抑郁Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL五羥色胺(5-H)開高感遲鈍心培穩(wěn)53a11--覺醒-精力增加NE升高a21改善認知β↑抗抑郁意志活動1〓→思睡一精力下降冖→減退NE降低2「→認知下降一→思維遲緩阝↓-情感低落阻滯性抑郁Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyLa11--覺醒-精力增加54前額皮質(zhì)D1受體↑認知改善DA高〈伏隔核口1受體↑增加快感紋狀體D2受體↑精神運動靈活前額皮質(zhì)D受體!→→認知下降思維遲緩DA傌伏嗝核D1受體!一快感缺失→情感低落紋狀體D2受體精神運動哪意志活動減退遲鈍阻滯性抑郁Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL前額皮質(zhì)D1受體↑認知改善555-TH濃度低下焦慮性抑郁NE濃度低下(主要阻滯性抑郁DA濃度低下(次要Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyL5-TH濃度低下焦慮性抑郁56ssR|s類藥物在臨床治療中的運用Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyLssR|s類藥物在臨床治療中的運用57ssR|制5TH再攝取門控系統(tǒng)→突觸間隙5T濃度升高情感遲鈍治療焦慮性抑郁治療焦慮障礙注:強迫癥、創(chuàng)傷后應(yīng)激驚強恐創(chuàng)傷障礙產(chǎn)生的原因亦包括了性障追怖后應(yīng)激障情感的高度敏感焦礙癥癥慮Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyLssR|制5TH再攝取門控系統(tǒng)→突觸間隙5T濃度升高58sSRs類藥物的副反應(yīng)(三高、三低)Valadononry.chAsposeslidesforNET4odientPEvaluationonly.CreatedwithAsposeSlidesforNET4.0dientProfilo71Copyright2019-2019AsposePtyLsSRs類藥物的副反應(yīng)(三高、三低)59抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件60抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件61抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件62抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件63抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件64抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件65抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件66抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件67抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件68抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件69抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件70抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件71抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件72抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件73抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件74抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件75抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件76抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件77抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件78抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件79抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件80抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件81抗抑郁藥物神經(jīng)遞質(zhì)的藥理課件8