PQM130-DataSheet-生命科學試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPQM130Cat.No.:HY-128346CASNo.:2089415-51-8分?式:C??H??NO?分?量:381.46作?靶點:Amyloid-β作?通路:NeuronalSignaling儲存?式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性數(shù)據(jù)體外實驗DMSO:1.82mg/mL(4.77mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.6215mL13.1075mL26.2151mL5mM---------10mM---------請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C儲存時，請在6個?內使?，-20°C儲存時，請在1個?內使?。BIOLOGICALACTIVITY?物活性PQM130?種能透過?腦的、魏羅酮-多奈哌齊雜化化合物，多靶點的候選藥物，可?于Aβ1-42低聚物引起的神經(jīng)毒性，還具有抗炎活性。PQM130具有神經(jīng)保護作?的、有潛?的抗AD藥物。體內研究PQM130(0.5-1mg/kg,i.p.,dailyfor10days)treatmentafterthei.c.v.AβOinjectionreducesoxidativedamageandneuroinflammationandinducescellsurvivalandproteinsynthesisthroughthemodulationofGSK3βandextracellularsignal-regulatedkinases(ERK1/2)[1].1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEAnimalModel:AdultmaleC57Bl/6mice(9weeksold,25-30gbodyweight)[1].Dosage:0.5and1.0mg/kg.Administration:IPinjectiondailyfor10days.Result:AmelioratedAβ1-42O-inducedcognitivedeficitsinmice.PreventedAβ1-42O-inducedneuronaldeathinmice.AntagonizedAβ1-42O-InducedOxidativeStressinMice.RegulatedGSK3βandERK1/2proteinexpressionsinmice.ReducedAβ1-42O-inducedastrocyticactivationinmice.REFERENCES[1].MorroniF,etal.PQM130,aNovelFeruloyl-DonepezilHybridCompound,EffectivelyAmelioratestheCognitiveImpairmentsandPathologyinaMouseModelofAlzheimer'sDisease.FrontPharmacol.2019Jun12;10:658.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;