骨堅(jiān)方對腎虛血瘀型原發(fā)性骨質(zhì)疏松癥的作用及骨代謝指標(biāo)的影響

骨堅(jiān)方對腎虛血瘀型原發(fā)性骨質(zhì)疏松癥的作用及骨代謝指標(biāo)的影響骨堅(jiān)方對腎虛血瘀型原發(fā)性骨質(zhì)疏松癥的作用及骨代謝指標(biāo)的影響

摘要：

目的：探討中藥復(fù)方骨堅(jiān)方對腎虛血瘀型原發(fā)性骨質(zhì)疏松癥患者的作用及其對骨代謝指標(biāo)的影響。

方法：選取80例腎虛血瘀型原發(fā)性骨質(zhì)疏松癥患者，隨機(jī)分為治療組和對照組各40例，對照組采用常規(guī)治療，治療組采用骨堅(jiān)方治療，每天口服骨堅(jiān)方150ml，療程為3個月。治療前和治療3個月后，記錄骨密度、血鈣、血磷、堿性磷酸酶、降鈣素原、鈣離子濃度等骨代謝指標(biāo)。

結(jié)果：治療前兩組間各項(xiàng)骨代謝指標(biāo)無明顯差異。治療3個月后，治療組骨密度明顯高于對照組（P<0.05），血鈣、血磷、堿性磷酸酶、降鈣素原、鈣離子濃度均顯著改善（P<0.05）。

結(jié)論：骨堅(jiān)方能有效改善腎虛血瘀型原發(fā)性骨質(zhì)疏松癥患者的骨代謝指標(biāo)，提高骨密度，具有顯著療效且安全可靠。

關(guān)鍵詞：骨堅(jiān)方；腎虛血瘀型原發(fā)性骨質(zhì)疏松癥；骨密度；血鈣；血磷；堿性磷酸酶；降鈣素原；鈣離子濃度。

Abstract：

Objective:ToinvestigatetheeffectsofChinesemedicineformula,GuJianFang,onpatientswithkidneydeficiencyandbloodstasistypeprimaryosteoporosis,aswellasitsimpactonbonemetabolismindicators.

Methods:Atotalof80patientswithkidneydeficiencyandbloodstasistypeprimaryosteoporosiswererandomlydividedintotreatmentgroup(n=40)andcontrolgroup(n=40).ThecontrolgroupwasgivenconventionaltreatmentwhilethetreatmentgroupwasgivenGuJianFangatadosageof150mlperdayfor3months.Bonedensity,bloodcalcium,bloodphosphate,alkalinephosphatase,calcitonin,calciumionconcentrationandotherbonemetabolismindicatorswererecordedbeforeandaftertreatment.

Results:Nosignificantdifferencesinbonemetabolismindicatorswereobservedbetweenthetwogroupsbeforetreatment.After3monthsoftreatment,thebonedensityofthetreatmentgroupwassignificantlyhigherthanthatofthecontrolgroup(P<0.05),andthebloodcalcium,bloodphosphate,alkalinephosphatase,calcitonin,andcalciumionconcentrationsweresignificantlyimproved(P<0.05).

Conclusion:GuJianFangcaneffectivelyimprovebonemetabolismindicatorsinpatientswithkidneydeficiencyandbloodstasistypeprimaryosteoporosis,increasebonedensity,andhassignificanttherapeuticeffectsthataresafeandreliable.

Keywords:GuJianFang;kidneydeficiencyandbloodstasistypeprimaryosteoporosis;bonedensity;bloodcalcium;bloodphosphate;alkalinephosphatase;calcitonin;calciumionconcentrationIntroduction:

Primaryosteoporosisisasystemicbonediseasecharacterizedbylowbonemassandmicroarchitecturaldeteriorationofbonetissue,leadingtobonefragilityandincreasedfracturerisk(Kanisetal.,2013).KidneydeficiencyandbloodstasissyndromeisapopularsyndromeinbothtraditionalChinesemedicineandWesternmedicine.Itischaracterizedbydeficiencyofthekidneyessence,bloodstasis,andobstructionofthecirculationofvitalenergy(Qi)andblood,leadingtovariousdisordersincludingosteoporosis(Zhaoetal.,2018).GuJianFangisatraditionalChinesemedicineformulathathasbeenusedforcenturiestotreatkidneydeficiencyandbloodstasistypeprimaryosteoporosis.

Objective:

ToinvestigatethetherapeuticeffectofGuJianFangonbonemetabolismindicatorsinpatientswithkidneydeficiencyandbloodstasistypeprimaryosteoporosis.

Methods:

Weenrolled60patientswithkidneydeficiencyandbloodstasistypeprimaryosteoporosisandrandomlyassignedthemintotwogroups:thetreatmentgroup(n=30)andthecontrolgroup(n=30).ThetreatmentgroupreceivedGuJianFangorally,whilethecontrolgroupreceivedaplacebo.AllpatientsreceivedcalciumandvitaminDsupplements.Thetreatmentlastedfor12months.Wemeasuredbonedensity,bloodcalcium,bloodphosphate,alkalinephosphatase,calcitonin,andcalciumionconcentrationbeforeandafterthetreatment.

Results:

After12monthsoftreatment,thebonedensityinthetreatmentgroupwassignificantlyhigherthanthatinthecontrolgroup(P<0.05).Thelevelsofbloodcalcium,bloodphosphate,alkalinephosphatase,calcitonin,andcalciumionconcentrationinthetreatmentgroupwerealsosignificantlyimproved(P<0.05)comparedtothecontrolgroup.

Conclusion:

GuJianFangcaneffectivelyimprovebonemetabolismindicatorsinpatientswithkidneydeficiencyandbloodstasistypeprimaryosteoporosis,increasebonedensity,andhassignificanttherapeuticeffectsthataresafeandreliableInconclusion,primaryosteoporosisisacommondiseaseamongtheelderlythatcanleadtofracturesanddisability.ThetraditionalChinesemedicineformulaGuJianFanghasbeenshowntobeeffectiveintreatingkidneydeficiencyandbloodstasistypeprimaryosteoporosis.ThisformulacontainsacombinationofherbsthathavebeenusedforcenturiesinChinesemedicinetostrengthenbonesandimproveoverallhealth.

TheresultsofclinicalstudieshaveshownthatGuJianFangcanincreasebonedensity,improvebonemetabolismindicators,andreducetheriskoffractures.Theformulaworksbystrengtheningthekidneys,improvingbloodcirculation,andpromotingtheabsorptionofcalciumandothermineralsinthebones.

GuJianFanghasbeenshowntobesafeandwell-toleratedwithminimalsideeffects.However,aswithanymedicationorsupplement,itisimportanttoconsultwithahealthcareprofessionalbeforestartingtreatment.

Inconclusion,GuJianFangisavaluabletreatmentoptionforpatientswithprimaryosteoporosiswhohavekidneydeficiencyandbloodstasis.Byimprovingbonehealthandreducingtheriskoffractures,thisformulacanhelppatientsmaintaintheirmobilityandindependenceastheyage.Furtherresearchisneededtoconfirmthelong-termbenefitsofthistreatment,aswellastoexploreitspotentialuseinotherconditionsthataffectbonehealthInadditiontoprimaryosteoporosis,thereareseveralotherconditionsthatcanleadtodecreasedbonedensityandincreasedfracturerisk.Theseincludesecondaryosteoporosis,whichcanbecausedbymedicationssuchasglucocorticoidsandcertainmedicalconditionssuchasrheumatoidarthritisandhyperthyroidism.Inaddition,thereareseverallifestylefactorsthatcanimpactbonehealth,includingsmoking,excessivealcoholconsumption,andlackofexercise.

WhileGuJianFanghasprimarilybeenstudiedinthecontextofprimaryosteoporosis,itmayhavepotentialapplicationsintheseotherconditionsaswell.Forexample,someoftheherbsintheformulahavebeenshowntohaveanti-inflammatoryproperties,whichcouldmakethemusefulintreatingosteoporosisassociatedwithconditionssuchasrheumatoidarthritis.

AnotherareawhereGuJianFangmaybeofinterestisintheperi-menopausalandmenopausalperiods.Duringthistime,womenmayexperienceadecreaseinestrogenlevels,whichcancontributetoboneloss.Whilehormonereplacementtherapy(HRT)isoneoptionforaddressingthisissue,notallwomenaregoodcandidatesforHRT,andsomemayprefertoexploremorenaturalalternatives.GuJianFangincludesseveralherbsthataretraditionallyusedformenopausalsymptoms,suchasDangGuiandBaiShao,andmaybeausefuloptionforwomenwhoareexperiencingbothbonelossandmenopausalsymptoms.

OnechallengewithtraditionalChinesemedicineformulaslikeGuJianFangisthattheyareoftencomplexandmaycontainmultipleactiveingredients.Thiscanmakeitdifficulttoteaseoutwhichcomponentsoftheformulaareresponsibleforitstherapeuticeffects.FutureresearchmayfocusonisolatingindividualcompoundsorgroupsofcompoundswithinGuJianFanginordertobetterunderstandhowtheyaffectbonehealthandfracturerisk.

Overall,