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2022-2023年浙江省舟山市公共英語五級(筆試)真題一卷(含答案)學(xué)校:________班級:________姓名:________考號:________
一、1.ListeningComprehension(15題)1.Whatisthecharacteristicofspecialtygoods?
A.Theyaregoodsthatcanbeboughtataspecialprice.
B.Theyarespecialkindsofproducts.
C.Theyarecharacterizedintheirbrands.
D.Theyneedspecialeffortstoget.
2.PartC
Directions:Youwillhearatalk.Asyoulisten,answerthequestionsorcompletethenotesinyourtestbookletforQuestions21-30bywritingNOTMORETHANTHREEwordsinthespaceprovidedontheright.YouwillhearthetalkTWICE.
Younowhave1minutetoreadQuestions21-30.
聽力原文:ForthoseofyouwhoareeitheralreadystudyingintheUnitedStatesorplanningtooneday,itmightbeinterestingtoknowsomethingabouttheforeignstudentpopulationintheUnitedStates.Fortheacademicyear1995/96therewasasumofapproximately344,000foreignstudentsstudyingintheUnitedStates.Thisfigureof344000mayseemlikeaverylargenumberuntilyoucompareitwiththetotalpopulationof241,000,000.Theforeignstudentpopulationhasbeengrowingforanumberofyearsandisstillgrowing,buttherateofincreasehasdroppedsharplyduringthe1990s.Duringthe1980s,thepopulationgrewquiterapidly.Forexample,between1985and1990.theaverageyearlyincreasewas12.5%.However,thepictureinthe1990sisquitedifferent.Therateofincreasehasdeclinedquitenoticeably.Infact,therateofincreasebetween1994/95and1995/96wasonly0.5%,orone-halfofonepercent.Althoughtheoverallrateofincreasehasdroppedtoonly0.5%.thenumberofstudentsfromsomepartsoftheworldisincreasingwhilethenumberofstudentsfromotherareasisdecreasing.Forexample,duringthissameperiod,thatisbetweentheacademicyears1994/95and1995/96,therewasadecreaseinthenumberofstudentsfromtheMiddleEast,whilethenumberofstudentsfromSouthandEastAsiaincreased.Thesechangesinthenumberofstudentscomingfromdifferentpartsoftheworldnodoubtreflectedchangingeconomicandpoliticalsituations.I'msureyouareawareofmanyofthesechanges,andperhapswecandiscussthematournextmeeting.Fortodaylet'sconfineourtalktofirst,adiscussionoftheoriginofthesestudents,or,inotherwords,wheretheycamefrom;second,thekindsofstudiestheypursue;and,finally,theacademiclevelstheyarefoundin.Ifwehavealittletimeleft,wemightquicklytalkaboutinwhichgeographicareasmostofthemgotoschool.
Let'sdiscusstheoriginsoftheforeignstudentpopulationintheUnitedStatesfortheacademicyear1995/96.Let'sdiscussitinorderfromthoseareassendingthemoststudentstothoseareassendingthefeweststudents.IfwelookatthefiguresprovidedbytheannualcensusofforeignstudentsintheUnitedStatesfortheyear1995/96,weseethatmostoftheforeignstudentsstudyingintheUnitedStatesduringthisyearwerefromSouthandEastAsia.ThisisaratherlargegeographicalareawhichincludessuchconutriesasChina,Korea,Pakistan,India,Malaysia,andIndonesia.Thetotalnumberofstudentsfromthisarea,SouthandEastAsiawas156,830.Inotherwords,roughly2outofevery5foreignstudentscomefromSouthandEastAsia.Almost24000ofthistotalwerefromChina.Malaysiawasclosebehindwithjustalittleover23000students.ThenextlargestnumberofstudentscamefromtheMiddleEast.ThenumberofstudentsfromtheMiddleEastcametoaboutone-thirdthenumberfromSouthandEastAsia.ThefourthlargestnumbercamefromSouthAmerica.NextcanleEurope,Africa,NorthAmerica,andOceania.Let'srecapitulatewhatwe'vesaid.ThelargestnumberofstudentsstudyingintheUnitedStatesduringtheacademicyear1995/96werefromSouthandEastAsia,followedbytheMiddleEast,SouthAmerica,Europe,Africa,NorthAmerica,andOceania.
Whatfieldsaretheselargenumbersofforeignstudentsstudyingin?Itprobablywon'tsurpriseyouthatthelargestnumberareinthefieldofengineering.Infact,21.7%ofthetotalnumberarestudyingengineering.Businessandmanagementisclosebehind,however,withatotalof18.9%.Thethirdmostpopularfieldwasmathematicsand
3.Theystartedworkingin1968basedontheobservationmadebyJung,thefounderof______.
4.Youcanfindyournoseinthedarknessbecauseofyour"feltimage".
A.TrueB.Fasle
5.StudyinginanEnglish-speakingcountryisaveryeffectivewaytolearnEnglish.
A.TrueB.Fasle
6.Chainsdon'tproducetheirowncoursebookmaterial.
A.RightB.Wrong
7.Shiraliprobablyliveduntil168;Tsurbaprobablyliveduntilage160.
A.TrueB.Fasle
8.Ourhumanfriendssometimesmaymakeusbored,butthefriendsinbooksmayalsobehurtbyus.
A.TrueB.Fasle
9.Thepossibilitiesofourliteraryexperiencesarealmostunlimited.
A.TrueB.Fasle
10.PartC
Directions:Youwillhearatalk.Asyoulisten,answerthequestionsorcompletethenotesinyourtestbookletforQuestions21-30bywritingNOTMORETHANTHREEwordsinthespaceprovidedontheright.YouwillhearthetalkTWICE.
Younowhave1minutetoreadQuestions21-30.
聽力原文:ForthoseofyouwhoareeitheralreadystudyingintheUnitedStatesorplanningtooneday,itmightbeinterestingtoknowsomethingabouttheforeignstudentpopulationintheUnitedStates.Fortheacademicyear1995/96therewasasumofapproximately344,000foreignstudentsstudyingintheUnitedStates.Thisfigureof344000mayseemlikeaverylargenumberuntilyoucompareitwiththetotalpopulationof241,000,000.Theforeignstudentpopulationhasbeengrowingforanumberofyearsandisstillgrowing,buttherateofincreasehasdroppedsharplyduringthe1990s.Duringthe1980s,thepopulationgrewquiterapidly.Forexample,between1985and1990,theaverageyearlyincreasewas12.5%.However,thepictureinthe1990sisquitedifferent.Therateofincreasehasdeclinedquitenoticeably.Infact,therateofincreasebetween1994/95and1995/96wasonly0.5%,orone-halfofonepercent.Althoughtheoverallrateofincreasehasdroppedtoonly0.5%,thenumberofstudentsfromsomepartsoftheworldisincreasingwhilethenumberofstudentsfromotherareasisdecreasing.Forexample,duringthissameperiod,thatisbetweentheacademicyears1994/95and1995/96,therewasadecreaseinthenumberofstudentsfromtheMiddleEast,whilethenumberofstudentsfromSouthandEastAsiaincreased.Thesechangesinthenumberofstudentscomingfromdifferentpartsoftheworldnodoubtreflectedchangingeconomicandpoliticalsituations.I'msureyouareawareofmanyofthesechanges,andperhapsyoucandiscussthematournextmeeting.Fortodaylet'sconfineourtalktofirst,adiscussionoftheoriginofthesestudents,or,inotherwords,wheretheycamefromsecond,thekindsofstudiestheypursue;and,finally,theacademiclevelstheyarefoundin.Ifwehavealittletimeleft,wemightquicklytalkaboutinwhichgeographicareasmostofthemgotoschool.
Let'sdiscusstheoriginsoftheforeignstudentpopulationintheUnitedStatesfortheacademicyear1995/96.Let'sdiscussitinorderfromthoseareassendingthemoststudentstothoseareassendingthefeweststudents.IfwelookatthefiguresprovidedbytheannualcensusofforeignstudentsintheUnitedStatesfortheyear1995/96,weseethatmostoftheforeignstudentsstudyingintheUnitedStatesduringthisyearwerefromSouthandEastAsia.Thisisaratherlargegeographicalareawhichincludessuchconu-triesasChina,Korea,Pakistan,India,Malaysia,andIndonesia.Thetotalnumberofstudentsfromthisarea,SouthandEastAsiawas156,830.Inotherwords,roughly2outofevery5foreignstudentscomefromSouthandEastAsia.Almost24000ofthistotalwerefromChina.Malaysiawasclosebehindwithjustalittleover23000students.ThenextlargestnumberofstudentscamefromtheMiddleEast.ThenumberofstudentsfromtheMiddleEastcametoaboutone-thirdthenumberfromSouthandEastAsia.ThefourthlargestnumbercamefromSouthAmerica.NextcameEurope,Africa,NorthAmerica,andOceania.Let'srecapitulatewhatwe'vesaid.ThelargestnumberofstudentsstudyingintheUnitedStatesduringtheacademicyear1995/96werefromSouthandEastAsia,followedbytheMiddleEast,SouthAmerica,Europe,Africa,NorthAmerica,andOceania.
Whatfieldsaretheselargenumbersofforeignstudentsstudyingin?Itprobablywon'tsurpriseyouthatthelargestnumberareinthefieldofengineering.Infact,21.7%ofthetotalnumberarestudyingengineering.Businessandmanagementisclosebehind,however,withatotalof18.9%.Thethirdmostpopularfieldw
11.Do-it-YourselfhasbecomeoneofMr.Miller'shobbies.
A.TrueB.Fasle
12.聽力原文:Now,letmefirstgiveyouabriefintroductiontotheAmericanpoet,EmilyDickinson.EmilyDickinsonwasAmerica'sbest-knownfemalepoetandoneoftheforemostauthorsinAmericanliterature.BorninAmherst,Massachusetts,Dickinsonwasthemiddlechildofaprominentlawyerandone-termUnitedStatescongressionalrepresentative,EdwardDickinson,andhiswife.EmilyNorcrossDickinson.From1840to1847sheattendedtheAmherstAcademy.a(chǎn)ndfrom1847to1848shestudiedattheMountHolyokeFemaleSeminary(nowMountHolyokeCollege)inSouthHadley,afewtripstoBostonforeyetreatmentsintheearly1860s。DickinsonremainedinAmherst.livinginthesamehouseonMainStreetfrom1855untilherdeath.Duringherlifetime,shepublishedonlyabout10ofhernearly2,000poems,innewspapers,Civilwarjournais,andapoetryanthology.ThefirstvolumeofPoemsofEmilyDickinsonwaspublishedin1890,afterDickinson'sdeath.
AlthoughfewofDickinson'spoemswereformallypublishedduringherlifetime,sheherself“published”bysendingoutatleastone-thirdofherpoemsinthemorethan1,000lettersshewrotetoatleast100differentcorrespondents.Dickinson'smethodofbindingabout800ofherpoemsinto40manuscript.booksanddistributingseveralhundredoftheminlettersisnowwidelyrecognizedasherparticularform.ofself-publication.Shealsoreadherpoemsaloudtoseveralpeople,includinghercousinsLouiseandFrancesNorcross,overaperiodofthreedecades.
Well.that'sallaboutherlife.Nowshallweconcentrateonherfamouspoem,“SuccessisCountedSweetest”.
InwhichstatewasEmilyDicksonborn?
A.Michigan.B.Ohio.C.Massachusetts.D.Washington.
13.Sugarincoldsweetdrinksslowstheliquidfromgettingintotheblood-stream.
A.TrueB.Fasle
14.WhatwaspotatousedforinEuropeatfirst?
15.Strokevictimssometimesrefusetoregardtheirinjuredsidesaspartsoftheirbodiesbecausetheyareunwillingtoadmittheirdisabilities.
A.RightB.Wrong
二、2.UseofEnglish(10題)16.
【C9】
17.
【C8】
18.(47)
19.(48)
20.
【C10】
21.Psychologiststakecontrastiveviewsofhowexternalrewards,from【31】______praisetocoldcash,affectmotivationandcreativity.Behaviorists,【32】______researchtherelation【33】______actionsandtheirconsequencesarguethatrewardscanimproveperformanceatworkandschool.Cognitiveresearchers,whostudyvariousaspectsofmentallife,maintain【34】______rewardsoftendestroycreativity【35】______encouragingdependence【36】______approvalandgiftsfromothers.
Thelatterviewhasgainedmanysupporters,especially【37】______educators.Butthecarefuluseofsmallmonetaryrewardssparks【38】______ingrade-schoolchildren,suggesting【39】______properlypresentedinducementsindeedaidinventiveness,【40】______toastudyintheJuneJournalofPersonalityandSocialPsychology"Ifkidsknowthey'reworkingfora【41】______andcanfocus【42】______arelativelychallengingtask,theyshowthemostcreativity",saysRobertEisenbergeroftheUniversityofDelawareinNewark."Butit'seasytokillcreativitybygivingrewardsfor【43】______performanceorcreatingtoo【44】______anticipationforrewards."
Ateacher【45】______continuallydrawsattentiontorewardsorwhohands【46】______highgradesforordinaryachievementendsup【47】______discouragedstudents,Eisenbergerholds.【48】______anexampleofthelatterpoint,henotesgrowingeffortsatmajoruniversitiestotightengradingstandardsandrestorefailing【49】Inearliergrades,theuseofso-calledtokeneconomies,in【50】______studentshandlechallengingproblemsandreceiveperformance-basedpointstowardvaluedrewards,showspromiseinraisingeffortandcreativity,theDelawarepsychologistclaims.
(31)
22.
【C5】
23.(43)
24.
【C6】
25.(32)
三、3.ReadingComprehension(15題)26.
______isalongwithmanycomparativelysmallbuildingsoneitherside?
27.Beforeabigexam,asoundnight'ssleepwilldoyoubetterthanporingovertextbooks.That,atleast,isthefolkwisdom.Andscience,intheform.ofbehavioralpsychology,supportsthatwisdom.Butsuchbehavioralstudiescannotdistinguishbetweentwocompetingtheoriesofwhysleepisgoodforthememory.Onesaysthatsleepiswhenpermanentmemoriesform.Theothersaysthattheyareactuallyformedduringtheday,butthen"edited"atnight,toflushawaywhatissuperfluous.
Totellthedifference,itisnecessarytolookintothebrainofasleepingperson,andthatishard.Butafteradecadeofpainstakingwork,ateamledbyPierreMaquetatLiegeUniversityinBelgiumhasmanagedtodoit.TheparticularstageofsleepinwhichtheBelgiangroupisinterestedisrapideyemovement(REM)sleep,whenbrainandbodyareactive,heartrateandbloodpressureincrease,theeyesmovebackandforthbehindtheeyelidsasifwatchingamovie,andbrainwavetracesresemblethoseofwakefulness.Itisduringthisperiodofsleepthatpeoplearemostlikelytoreliveeventsofthepreviousdayindreams.
Dr.MaquetusedanelectronicdevicecalledPETtostudythebrainsofpeopleastheypracticedataskduringtheday,andastheysleptduringthefollowingnight.Thetaskrequiredthemtopressabuttonasfastaspossible,inresponsetoalightcomingoninoneofsixpositions.Astheylearnthowtodothis,theirresponsetimesgotfaster.Whattheydidnotknowwasthattheappearanceofthelightssometimesfollowedapattern—whatisreferredtoas"artificialgrammar".Yetthereductionsinresponsetimeshowedthattheylearntfasterwhenthepatternwaspresentthanwhentherewasnot.
Whatismore,thosewithmoretolearn(i.e.the"grammar",aswellasthemechanicaltaskofpushingthebutton)havemoreactivebrains.The"editing"theorywouldnotpredictthat,sincethenumberofirrelevantstimuliwouldbethesameineachcase.Andtoeliminateanydoubtsthattheexperimentalsubjectswerelearningasopposedtounlearning,theirresponsetimeswhentheywokeupwereevenquickerthanwhentheywenttosleep.
Theteam,therefore,concludedthatthenerveconnectionsinvolvedinmemoryarereinforcedthroughreactivationduringREMsleep,particularlyifthebraindetectsaninherentstructureinthematerialbeinglearnt.Sonow,ontheeveofthatcrucialtest,mathsstudentscansleepsoundlyintheknowledgethatwhattheywillrememberthenextdayarethebasicrulesofalgebraandnottheincoherenttalkfromtheradionextdoor.
Researchersinbehavioralpsychologyaredividedwithregardto______.
A.howdreamsaremodifiedintheircourses
B.thedifferencebetweensleepandwakefulness
C.whysleepisofgreatbenefittomemory
D.thefunctionsofagoodnight'ssleep
28.
Accordingtothepassage,whichofthefollowingisnottrue?
A.SomeAmericanswouldnotacceptthevalueofconservationandenvironmentprotection,becausethisvaluewouldprobablymakethemunemployed.
B.ManyAmericanshavebeenusedtowasting,soitwillbedifficultforthemtoacceptthenewvalueofconservation.
C.SomeoldvaluesarestillhavingaverystronginfluenceonAmericanpeople,althoughtheyareharmfulinthisnewage.
D.MostAmericanshavefullyrealizedtheneedtoprotecttheenvironment,sotheyhavetakenmeasurestorecyclejunkedgoods.
29.PartC
Directions:Answerquestions71-80byreferringtothefollowinggames.
Note:AnswereachquestionbychoosingA,BorCandmarkitonANSWERSHEET1.Somechoicesmayberequiredmorethanonce.
A=TheImperialPalaceB=TheTempleofHeavenC=PotalaPalaceD=JokhangTempleWhichpalaceortemple...
isthespiritualcenterofTibet?71.______
iscircularinthenorthernpartwhilesquareinthesouthernpart?72.______
presentsthelargestandmostcompleteensembleoftraditionalarchitecture?73.______
coversabuildingspaceof90thousandsquaremeters?74.______
istheoldestoneamongthefourinthetext?75.______
canpresentthevisitorthesignificanceofHeavenKitchen?76.______
isacombinationofarchitecturalstylesfromHan,TibetanandNepalese?77.______
wasthereligiousandpoliticalcenterofoldTibet?78.______
isalongwithmanycomparativelysmallbuildingsoneitherside?79.______
presentsanedictsignedwiththeGreatFifth'shandprint?80.______
A
TheImperialPalace
Whatstrikesonefirstinabirds-eyeviewofBeijingproperisavasttractofgoldenroofsflashingbrilliantlyinthesunwithpurplewallsoccasionallyemergingamidthemandastretchofluxurianttreeleavesflankingoneachside.ThatistheformerImperialPalace,popularlyknownastheForbiddenCity,fromwhichtwenty-fouremperorsoftheMingandQingDynastiesruledChinaforsome500years—from1420to1911.TheMingEmperorYongLe,whousurpedthethronefromhisnephewandmadeBeijingthecapital,ordereditsconstruction,onwhichapproximately10,000artistsandamillionworkmentoiledfor14yearsfrom1406to1420.Atpresent,thePalaceisanelaboratemuseumthatpresentsthelargestandmostcompleteensembleoftraditionalarchitecturecomplexandmorethan900,000piecesofcourttreasuresinalldynastiesinChina.
LocatedinthecenterofBeijing,theentirepalacearea,rectangularinshapeand72hectaresinsize,issurroundedbywallstenmetershighandamoat52meterswide.Ateachcornerofthewallstandsawatchtowerwithadouble-eaveroofcoveredwithyellowglazedtiles.
Themainbuildings,thesixgreathalls,onefollowingtheother,aresetfacingsouthalongthecentralnorth-southaxisfromtheMeridianGate,thesouthentrance,toShenwumen,thegreatgatepiercinginthenorthwall.Oneithersideofthepalacearemanycomparativelysmallbuildings.SymmetricallyinthenortheasternsectionliethesixEasternPalacesandinthenorthwesternsectionthesixWesternPalaces.ThePalaceareaisdividedintotwoparts:theOuterCourtandtheInnerPalace.Theformerconsistsofthefirstthreemainhalls,wheretheemperorreceivedhiscourtiersandconductedgrandceremonies,whilethelatterwasthelivingquartersfortheimperialresidence.AttherearoftheInnerPalaceistheImperialGardenwheretheemperorandhisfamilysoughtrecreation.
B
TheTempleofHeaven
TheTempleofHeavenwasinitiallybuiltinYongleYear18oftheMingDynasty(in1420).Situatedinthesouthernpartofthecity,itcoversthetotalareaof273hectares.WiththeadditionsandrebuildingduringtheMing,QingandotherDynasties,thisgrandsetofstructureslookmagnificentandglorious;thedignifiedenvironmentappearssolemnandrespectful.ItistheplaceforbothMingandQingDynasty'sEmperorstoworshipHeavenandprayforgoodharve
30.
Whycanmanypeoplesee“silverlinings”totheeconomicshowdown?
A.Theywouldbenefitincertainways.
B.Thestockmarketshowssignsofrecovery.
C.Suchaslowdownusuallyprecedesaboom.
D.Thepurchasingpowerwouldbeenhanced.
31.Themanbehindthisnotion,JackMaple,isadandywhoaffectsdarkglasses,homburgs(翹邊帽)andtwo-toeshoes;yethehasbecomesomethingofalegendinAmerica'spolicedepartments.Forsomeyears,startinginNewYorkandmovingontohigh-crimespotssuchasNewOrleansandPhiladelphia,heandhisbusinesspartner,JohnLinderhavemarketedatwo-tiersystemforcuttingcrime.
First,policedepartmentshavetosortthemselvesout:rootoutcorruption,streamlinetheirbureaucracy,andmakemorecontactwiththepublic.Second,theyhavetoadoptacomputersystemcalledComstatwhichhelpsthemtoanalyzestatisticsofallmajorcrimes.Theseareconstantlykeyedintothecomputer,whichthendisplayswhereandwhentheyhaveoccurredonacolor-codedmap,enablingthepolicetomonitorcrimetrendsastheyhappenandtospothigh-crimeareas.InNewYork,Comstat'sstatisticalmapsareanalyzedeachweekatameetingofthecity'spolicechiefandprecinctcaptains.
MessrsMapleandLinder("specialistsincrime-reductionservices")havenodoubtthattheirsystemisamaincontributortothedropincrime.WhentheyintroduceditinNewOrleansinJanuary1997,violentcrimedroppedby22%inayear;whentheymerelystartedworkinginformallywiththepolicedepartmentinNewark,NewJersey,violentcrimefellby13%.Policedepartmentsarenowlininguptopayasmuchas$50,000amonthforthesetwomentoputthemstraight.
Probablyallthesenewpoliciesandbitsoftechnicalwizardry,addedtogether,havemadeabigdifferencetocrime.Butthereremainanomaliesthatcannotbeexplained,suchasthefactthatcrimeinWashingtonD.C.,hasfallenasfastasanywhere,althoughthepolicedepartmenthasbeencorruptandhopelessand,inlargestretchesofthecity,neitherpolicenorresidentsseemdisposedtofightthecriminalsintheirmidst.
Themoreimportantreasonforthefallincrimerates,manysay,isamuchlesssophisticatedone.Itisafactthatcrimerateshavedroppedastheimprisonmentratesoared.In1997thenationalincarcerationrate,at645per100000peoplewasmorethandoubletheratein1985,andthenumberofinmatesincityandcountyjailsroseby9.4%.almostdoubleitsannualaverageincreasesince1990.Surelysomecriminologistsargue,onesetoffiguresisthecauseoftheother.Itisprecisebecausemorepeoplearebeingsenttoprison,theyclaimthatcrimeratesarefalling.A1993studybytheNationalAcademyofSciencesactuallyconcludedthatthetriplingoftheprisonpopulationbetween1975and1989hadloweredviolentcrimeby10-15%.
Yetcauseandeffectmaynotbesoobviouslylinked.Tobeginwith,thesaleandpossessionofdrugsarenotcountedbytheFBIinitscrimeindex,whichislimitedtoviolentcrimesandcrimesagainstproperty.Yetdrugoffencesaccountformorethanathirdoftherecentincreaseinthenumberofthosejailed;since1980,theincarcerationratefordrugarrestshasincreasedby1000%.Andalthoughaboutthree-quartersofthosegoingtoprisonfordrugoffenceshavecommittedothercrimesaswell,thereisnotyetacrystal-clearconnectionbetweenfillingthejailswithdrug-pushersandadeclineintherateofviolentcrime.Again,thoughnationalfiguresaresuggestive,localonesdiverge:theplaceswherecrimehasdroppedmostsharply(suchasNewYorkCity)arenotalwaystheplaceswhereincarcerationhasrisenfastest.
JackMaplestartedhiscareerin______.
A.PhiladelphiaB.OregonC.NewOrleansD.NewYork
32.(73)
33.At18,AshanthiDeSilvaofsuburbanClevelandisalivingsymbolofoneofthegreatintellectualachievementsofthe20thcentury.Bornwithanextremelyrareandusuallyfataldisorderthatleftherwithoutafunctioningimmunesystem(the"bubble-boydisease",namedafteranearliervictimwhowaskeptaliveforyearsinasterileplastictent),shewastreatedbeginningin1990witharevolutionarynewtherapythatsoughttocorrectthedefectatitsverysource,inthegenesofherwhitebloodcells.Itworked.Althoughherlastgene-therapytreatmentwasin1992,sheiscompletelyhealthywithnormalimmunefunction,accordingtooneofthedoctorswhotreatedher,W.FrenchAndersonoftheUniversityofSouthernCalifornia.Researchershavelongdreamedoftreatingdiseasesfromhemophiliatocancerbyreplacingmutantgeneswithnormalones.Andthedreamingmaycontinuefordecadesmore."Therewillbeagene-basedtreatmentforessentiallyeverydisease,"Andersonsays,"within50years."
It'snotentirelyclearwhymedicinehasbeensoslowtobuildonAnderson'searlysuccess.TheNationalInstitutesofHealthbudgetofficeestimatesitwillspend$432millionongene-therapyresearchin2005,andthereisnoshortageofpromisingleads.Thetherapeuticgenesareusuallydeliveredthroughvirusesthatdon'tcausehumandisease."ThevirusissortoflikeaTrojanhorse,"saysRonaldCrystalofNewYorkPresbyterian/WeillCornellMedicalCollege."Thecargoisthegene."
AttheUniversityofPennsylvania'sAbramsohCancerCenter,immunologistCarlJunerecentlytreatedHIVpatientswithageneintendedtohelptheircellsresisttheinfection.AtCornellUniversity,researchersarepursuinggene-basedtherapiesforParkinson'sdiseaseandararehereditarydisorderthatdestroyschildren'sbraincells.AtStanfordUniversityandtheChildren'sHospitalofPhiladelphia,researchersaretryingtofigureouthowtohelppatientswithhemophiliawhotodaymustinjectthemselveswithexpensiveclottingdrugsforlife.Animalexperimentshaveshowngreatpromise.
Butsomehow,thingsgetlostinthetranslationfromlaboratorytopatient.Inhumantrialsofthehemophiliatreatment,patientsshowaresponseatfirst,butitfadesovertime.Andthefieldhasstillnotrecoveredfromthesetbackitsufferedin1999,whenJesseGelsinger,an18-year-oldwithararemetabolicdisorder,diedafterreceivinganexperimentalgenetherapyattheUniversityofPennsylvania.Someexpertsworrythatthefieldwillbetarnishedfurtherifthenextpeopletobenefitarenotpatientsbutathletesseekinganedge.Thissummer,researchersattheSalkInstituteinSanDiegosaidtheyhadcreateda"marathonmouse"byimplantingagenethatenhancesrunningability;already,officialsattheWorldAnti-DopingAgencyarepreparingtotestathletesforsignsof"genedoping".Buttheprincipleisthesame,whetheryou'retryingtohelpahealthyrunnerrunfasterorallowamuscular-dystrophypatienttowalk."Everybodyrecognizesthatgenetherapyisaverygoodidea,"saysCrystal."Andeventuallyit'sgoingtowork."
ThecaseofAshanthiDesilvaismentionedinthetextto______.
A.showthepromiseofgene-therapy
B.giveanexampleofmoderntreatmentforfataldiseases
C.introducethea
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