課件正常淋巴結(jié)

淋病變基本診斷模細(xì)胞學(xué)（皮質(zhì)區(qū)TB淋病變基本診斷模式 淋病變基本診斷模式組織學(xué)結(jié)構(gòu)異 淋病變基本診斷模式淋病變基本診斷模式核膜，不規(guī)則核 RS Lacunar Popcorn

淋病變基本診斷模式淋病變基本診斷模式淋病變基本診斷模式淋病變基本診斷模式淋病變基本診斷模式 BlastoidBurkkitt‘s（foliiculargrowthpattern）淋病變基本診斷模式淋病變基本診斷模式淋病變基本 Castleman淋病變基本診斷模式骨髓（CLL）或淋（SLL）正常結(jié)構(gòu)破壞，腫瘤細(xì)胞淋淋Blastoid WesuggestthatthenodularorfollicularpatternofT-celllymphomaarisesbyspreadoftumorcellsfromthepatentsurroundingperifollicularsinusintothemarginalandmantlezonesofreactivefollicles.淋病變基本診斷模式 淋病變基本診斷模式淋病變基本診斷模式?Largeexpansilefolliclesarescatteredamongusualreactivefollicles,andareseveraltimestheir?Largefolliclescomprisemostlysmall–Admixedisolatedorsmallgroupsofgerminalcentercells–Somemayhavesingleormultipleremnantgerminalcenters(whichcanbequi ?NoL&HFollicularlymphoma(floral

淋病變基本診斷模式炎 淋病變基本診斷模式淋病變基本診斷模式HL,NSHL‘‘lacunar淋病變基本診斷模式淋病變基本診斷模式LRHL:LargenodularpatternsimilartoNLPHL;residualGCcanbeseenNodulesandinterfollicularzonemainlycomposedofsmalllymphocytes,withfewsmacellsorRScellsarescatteredwithinandbetweenthenodules.Insomecases,theyarefoundinexpandedmantlezones(so-calledfollicularHL).RScellsareneverfoundingerminalcenters.NodularlymphocytepredominantHL, – ‘Popcorncell’’,alsoknownasL&H(lymphocyticandhistiocyticFollicularlymphoma(floralFollicularlymphoma(floralDifferencesfromAllfolliclesareFeaturestoconfirmMonotonyofcellpopulationingerminalBcl-2immunoreactivityingerminalIglightchainAtypicalpolymorphouswithagranuloma-likeDiagnosis:B-CLLwithRSB-CLL/SLLwithRS-likeInrarecasesofB-CLL/SLL,therearescatteredlargeatypicalRS-likecellswithactivatedBcell,RScellorintermediateimmunophenotypeLargecellsareselectivelyEBV+(EBER+,HowtoreachaMonotonousbackgroundsmalllymphocytes+/-proliferationcentersSmalllymphocytesareBcellswithcoexpressionof+/- T或K細(xì)淋病變基本診斷模式LennertLennertLennert T或K細(xì)淋病變基本診斷模式CNSLshowacharacteristicgrowthpatternwithanangiocentricinfiltrationandsplittingofbloodvessels.Ingeneralthetumourcellhibitadiffusegrowthpattern;onlyatthetumourbordersthecellsmaybeconfinedtoperivascularspaces.HistopathologicaldetectionofeitheroneoftheseorbothgrowthpatternsdependonthesiteofbiopsywithinthetumouranddonotallowtodiscriminatweendisttsubtypesofPCNSL.case淋病變基本診斷模式淋病變基本診斷模式淋淋 淋病變基本診斷模式 withRS-likeBcellsVeryrare--morelikelytobeseeninScatteredverylargeRS-likecells–B-lineage,EBV+,CanbemistakenforclassicalHodgkinlymphomaorHowtoreachadiagnosis:recognizingtheatypiaofthebackgroundTlymphoidcellscase變變淋病變基本診斷模式淋病變基本診斷模式

淋病變基本診斷模式Oftenyoungage,M>SolitaryenlargedlymphnoderatherthanmattedMostlyinvolvingsuperficialnodes(cervical,inguinal,axillary);almostnevermediastinalOftenstageI/IIdiseaseatpresentationPrognosis：10年率3-5%BcellNLPHL:LymphnodeUsuallytotallyButarimofresidualnodaltissue(withreactivefollicles)canoccurinperiphery;onlyrarelyarereactivefolliclesintima ymixedwiththeneosticThecharacteristicLarge,round,dark-Usuallycloselypacked,sometimesMayappearmottledduetopresenceofMaybesurroundedbyawreathofinnodulesMostlyR-Scellvariants