卵巢性索間質(zhì)腫瘤課件-002

卵巢性索-間質(zhì)腫瘤卵巢性索-間質(zhì)腫瘤1分化及分類●女性性索分化層細胞露:66%卵泡纖維瘤組:28%卵泡膜、纖維輯/肉瘤化性間質(zhì)3%兩性混合分化兩性母細胞、環(huán)管狀性索瘤親分性索質(zhì)腫瘤類固醵細胞分化leydig細胞瘤、聞質(zhì)黃瘤非特異性類固酸細胞男性性素分化夜持Leydig細胞:1%間質(zhì)Lydg細胞瘤分化及分類2粒層細胞癟(GcT。單純由或>]0%的明粒層細胞組成禮景常為纖雄卵泡膜瘤樣●具有惡性潛能10%50%可氯發(fā)分型成年型和幼年型粒層細胞癟(GcT3(-減年型(AGcT1占卵粒層細胞瘤的95%2年齡:中年至絕經(jīng)期婦女(>40y)3大體:多為單側(cè)(95%),分葉狀切面黃色實性/竇性可伴出血媧死(-減年型(AGcT44鏡下所見:奧型粒層細胞:胞漿少,被成卵圓形飛見核溝,被分<1-2/10HPF黃素化懂酸性或空泡狀胞漿,失去特征性溝偶見奇異形核:不影購預后排列高分化:微(ca|-Exner小體/巨濾泡啼分化:島狀狀低分化:緞帶樣、彌漫漫潤(肉瘤樣)間質(zhì):纖雄卵泡膜樣?？砂榫衷畈亓幼?鏡下所見:5粒層細胞瘤:2teSsa%粒層細胞瘤6[rmor,mirch和g。26[rmor,mirch7tumoryththadrionodFig.26.11Well-ditferentiatedFig-26.12Wwl-citferentiatedgranulosacelltuscumisimportatumoryththadrionodFig.268題F|g.26.14ellsor(B)smallspindledcells.題95.粒層綱胞磨變異型:1)TubularpatterneTubulesindistinguishablefromthoseofasertolicelltumorarepresentoButtubulesarealmostinvariablyminor5.粒層綱胞磨變異型:10卵巢性索間質(zhì)腫瘤課件_00211卵巢性索間質(zhì)腫瘤課件_00212卵巢性索間質(zhì)腫瘤課件_00213卵巢性索間質(zhì)腫瘤課件_00214卵巢性索間質(zhì)腫瘤課件_00215卵巢性索間質(zhì)腫瘤課件_00216卵巢性索間質(zhì)腫瘤課件_00217卵巢性索間質(zhì)腫瘤課件_00218卵巢性索間質(zhì)腫瘤課件_00219卵巢性索間質(zhì)腫瘤課件_00220卵巢性索間質(zhì)腫瘤課件_00221卵巢性索間質(zhì)腫瘤課件_00222卵巢性索間質(zhì)腫瘤課件_00223卵巢性索間質(zhì)腫瘤課件_00224卵巢性索間質(zhì)腫瘤課件_00225卵巢性索間質(zhì)腫瘤課件_00226卵巢性索間質(zhì)腫瘤課件_00227卵巢性索間質(zhì)腫瘤課件_00228卵巢性索間質(zhì)腫瘤課件_00229卵巢性索間質(zhì)腫瘤課件_00230卵巢性索間質(zhì)腫瘤課件_00231卵巢性索間質(zhì)腫瘤課件_00232卵巢性索間質(zhì)腫瘤課件_00233卵巢性索間質(zhì)腫瘤課件_00234卵巢性索間質(zhì)腫瘤課件_00235卵巢性索間質(zhì)腫瘤課件_00236卵巢性索間質(zhì)腫瘤課件_00237卵巢性索間質(zhì)腫瘤課件_00238卵巢性索間質(zhì)腫瘤課件_00239卵巢性索間質(zhì)腫瘤課件_00240卵巢性索間質(zhì)腫瘤課件_00241卵巢性索間質(zhì)腫瘤課件_00242卵巢性索間質(zhì)腫瘤課件_00243卵巢性索間質(zhì)腫瘤課件_00244卵巢性索間質(zhì)腫瘤課件_00245卵巢性索間質(zhì)腫瘤課件_00246卵巢性索間質(zhì)腫瘤課件_00247卵巢性索間質(zhì)腫瘤課件_00248卵巢性索間質(zhì)腫瘤課件_00249卵巢性索間質(zhì)腫瘤課件_00250卵巢性索間質(zhì)腫瘤課件_00251卵巢性索間質(zhì)腫瘤課件_00252卵巢性索間質(zhì)腫瘤課件_00253卵巢性索間質(zhì)腫瘤課件_00254