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Globalstatusreport
onalcoholandhealthandtreatment
ofsubstanceusedisorders
Globalstatusreport
onalcoholandhealthandtreatment
ofsubstanceusedisorders
Globalstatusreportonalcoholandhealthandtreatmentofsubstanceusedisorders
ISBN978-92-4-009674-5(electronicversion)
ISBN978-92-4-009675-2(printversion)
?WorldHealthOrganization2024
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Content
Foreword.....................................................................................................iv
Acknowledgements.........................................................................................v
Abbreviations..............................................................................................viii
Executivesummary........................................................................................xi
Introduction...............................................................................................xvii
1.Psychoactivesubstanceuse,healthanddevelopment...........................................1
2.Alcoholconsumption,alcohol-relatedharmandpolicyresponses............................23
2.1Globalstatusandtrendsinalcoholconsumption(SDG3.5.2indicator)....................26
2.2Globalstatusandtrendsinthehealthconsequencesofalcoholconsumption............43
2.3Alcoholpolicies....................................................................................64
3.Strengtheningtreatmentforsubstanceusedisorders:towardsuniversal
healthcoverage.........................................................................................79
3.1Treatmentofsubstanceusedisorders..........................................................82
3.2TreatmentcoverageandServiceCapacityIndex(SCI)forsubstanceusedisorders.....105
4.Conclusions:towardsattainmentofSDGhealthtarget3.5...................................119
Annexes....................................................................................................129
Annex1.Datasourcesandmethods...............................................................131
Annex2.Statisticalannexonalcoholandhealth.................................................165
Annex3.Statisticalannexontreatmentofsubstanceusedisorders...........................244
Annex4.Estimatesofdrug-attributablediseaseburden........................................294
References.................................................................................................297
iii
Foreword
Psychoactivesubstanceuse,includingdrugsandproductscontaining
alcohol,carriesasignificanthealthandsocialburden.In2019alone,
alcoholcaused2.6milliondeathsworldwide,andpsychoactive
drugsaccountedfornearly600000deaths.Psychoactivesubstance
usealsoresultsinnegativesocialandeconomicconsequencesfor
communities.Assuch,theimpactofsubstanceuseonhealthand
developmentisrecognizedinthe2030AgendaforSustainable
Development,throughSustainableDevelopmentGoals(SDG)health
target3.5,whichcallsforthestrengthenedpreventionofsubstance
useandtreatmentofsubstanceusedisorders.
DrTedrosAdhanomGhebreyesus
Director-General
WorldHealthOrganization
Thisreportpresentsacomprehensiveglobalupdateonthestatusandprogressaroundthetwo
keyindicatorssetoutinSDGhealthtarget3.5:alcoholconsumptionandtreatmentcoveragefor
substanceusedisorders.Itsetsouteightpriorityareaswhereactionneedstobetaken.
Despitesomereductioninalcoholconsumptionandrelatedharmworldwidesince2010,the
healthandsocialburdenduetoalcoholuseremainsunacceptablyhigh.Youngerpeopleare
disproportionatelya?ectedbyalcoholconsumption:thehighestproportionofalcoholattributable
deaths–13%–in2019wasamongpeopleaged20-39years.
Whilewehaveseenaslightincreaseinthenumberofcountriesadoptingnationalalcoholpolicies,
littleprogresshasbeenmadeinimplementingthehigh-impactpolicyinterventionsprovento
reducealcohol-relatedharm,suchasimpactfulpricingpoliciesorcomprehensivemarketingand
availabilityrestrictions.TheWHOGlobalalcoholactionplan2022-2030setsoutthese‘bestbuys’and
supportscountriestostrengthenactionsonreducingalcohol-relatedharms,butimplementation
e?ortsmustbesteppedupurgently.
Thereportalsohighlightsanothercriticalgap:accesstoqualityandethicaltreatmentforsubstance
usedisordersisstilllargelylimitedoruna?ordableforthosemostinneed.Thisa?ectsalmosthalf
abillionofpeopleworldwidewholivewithalcoholordrugusedisorders.Stigma,discrimination
andmisconceptionsaboutthee?icacyoftreatmentcontributetogapsinhealthservicesandlow
prioritizationofsubstanceusedisordersbyhealthanddevelopmentagencies.
WearenotontracktoachievesignificantprogressforSDGtarget3.5unlessweaccelerateaction
now.WHOremainscommittedtoworkingwithgovernments,internationalpartners,civilsociety
organizationsand,asappropriate,otherstakeholderstomakerealandmeasurableprogress
towardsthesetargets.Giventheheavyhealthandsocialburdenthatpsychoactivesubstanceuse
continuestohaveonpeople,theirfamiliesandcommunitiesacrosstheworld,e?ortstoreduce
psychoactivesubstanceusemustbeapublichealthpriority.
iv
Acknowledgements
ThisreportwaspreparedbytheAlcohol,DrugsandAddictiveBehavioursUnit(ADA)inthe
DepartmentofMentalHealth,BrainHealthandSubstanceUse(MSD)oftheWorldHealth
Organization(WHO),Geneva,Switzerland.Thereportwasconceptualizedby,anddeveloped
undertheoverallguidanceof,DévoraKestel(Director,MSD)andVladimirPoznyak(UnitHead,
ADA)withintheframeworkofWHOactivitiesonglobalmonitoringtoinformprogresstowards
achievementofSustainableDevelopmentGoal(SDG)healthtarget3.5andimplementationof
theGlobalstrategytoreducetheharmfuluseofalcohol.Thedevelopmentofthisreportislinked
toWHO’sworkontheglobalinformationsystemsonalcoholandhealthandresourcesforthe
preventionandtreatmentofsubstanceusedisorders.
WithinWHO’ssecretariat,MinghuiRenattheinitialstageandsubsequentlyJér?meSalomon
providedguidanceandsupporttotheprojectintheirconsecutiverolesasAssistantDirector-
General,UniversalHealthCoverage/CommunicableandNoncommunicableDiseases(UCN).
ProductionofthisreportwasledbyVladimirPoznyakwhoalsoservedasanexecutiveeditorof
thereport.TheWHOsta?involvedindevelopmentandproductionofthereportwere:Alexandra
Fleischmann,DzmitryKrupchankaandDagRekveoftheADAunitatWHOheadquartersinGeneva.
IlincaRaduandJiangLongcontributedtothedatacollection,compilationandproductionofthe
reportintheircapacityasconsultants.JuanTellooftheWHODepartmentofHealthPromotion
providedtechnicalinputtothedevelopmentofthechapteronalcoholandhealth.BochenCao,
HaidongWang,JessicaHoandAnnetMahananioftheWHODivisionofData,Analytics&Delivery
forImpact(DDI)contributedtotheestimatesofalcohol-anddrug-attributablediseaseburdenand
providedtechnicalinputatdi?erentstagesofthereport’sdevelopment.Estimatesofdrug-attributable
diseaseburdenwereproducedbyColinMathers.LeanneRiley,ReginaGutholdandMelanieCowanof
WHO’sNoncommunicableDiseasesDepartmentprovideddatafromtheWHO-supportedsurveysand
technicalinputtothereport.KtFriarandCameronDenneyoftheDDIdivisioncreatedthemapsused
inthereport,andPhilippeBoucher,ZoeBrillantesandJovenLarinofthesamedivisionweretechnical
counterpartsfromtheGlobalHealthObservatoryforupdatingtheglobalinformationsystems.
Fortheirsignificantcontributionstoindividualchaptersandannexesweacknowledgethe
following:
Chapter1:RobinRoom,MeganCook,Anne-MarieLaslett,ThomasBabor,VladimirPoznyak.
Chapter2:JürgenRehm,KevinShield,DavidJernigan,PamelaTrangenstein,DagRekve,Vladimir
Poznyak.
Chapter3:DzmitryKrupchanka,TomasFormanek,ThomasBabor,VladimirPoznyak.
Chapter4:VladimirPoznyak,MaristelaGoldnadelMonteiro,DavidBramley.
Annexes:KevinShield,PamelaTrangenstein,AlexandraFleischmann,DzmitryKrupchanka,
IlincaRadu.
v
Globalstatusreportonalcoholandhealthandtreatmentofsubstanceusedisorders
ThecollectionofdatawithintheframeworkoftheWHOglobalsurveyonprogressonSDGhealth
target3.5andthedevelopmentofthisreportwasundertakenincollaborationwiththesixWHO
regionalo?icesandWHOcountryo?ices.Keycontributorstothedatacollectionandcompilation
intheWHOregionalo?iceswere:
WHOAfricanRegion:FlorenceBaingana
WHORegionoftheAmericas:MaristelaGoldnadelMonteiro,SohiIvneet
WHOEasternMediterraneanRegion:KhalidSaeed,WafaaElsawi
WHOEuropeanRegion:CarinaFerreira-Borges,SergeyBychkov,MariaNeufeld
WHOSouth-EastAsiaRegion:NazneenAnwar
WHOWesternPacificRegion:MartinVandendyck,CarolineLukaszyk,KiraFortune,Amy
Bestman.
ThefollowingcolleaguesfromtheWHOregionalo?icesprovidedtechnicalinputatdi?erent
stagesoftheprojectdevelopment:FlorenceBainganaandChidoRatidzaiRwafaMadzvamutse
(AfricanRegion),RenatoOliveiraandMarioZapata(RegionoftheAmericas/PanAmericanHealth
Organization),KhalidSaeedandDaliaElasi(EasternMediterraneanRegion),CarinaFerreira-
BorgesandMariaNeufeld(EuropeanRegion),AndreaBruni(South-EastAsiaRegion),Martin
Vandendyck,XiYinandDanFang(WesternPacificRegion).
Technicaladviceandreviewsduringtheprocessofdevelopmentofthedatacollectiontooland
productionoftheestimatesincludedinthisreportwereprovidedbymembersoftheTechnical
AdvisoryGrouponAlcoholandDrugEpidemiology,includingSawitriAssanangkornchai,Prince
ofSongklaUniversity,Songkla,Thailand;GuilhermeBorges,NationalInstituteofPsychiatry,
MexicoCity,Mexico;LouisaDegenhardt,NationalDrugandAlcoholResearchCentre,Universityof
SouthWales,Sydney,Australia;GerhardGmel,UniversityHospitalCentre,Lausanne,Switzerland;
GopalakrishnaGururaj,NationalInstituteofMentalHealthandNeurosciences(NIMHANS),
Bangalore,India;WeiHao,MentalHealthInstitute,CentralSouthUniversity,Changsha,China;
MatthewHickman,UniversityofBristol,Bristol,UnitedKingdomofGreatBritainandNorthern
Ireland;SusumuHiguchi,KurihamaMedicalandAddictionCenter,Kanagawa,Japan;PiaM?kel?,
FinnishInstituteforHealthandWelfare(THL),Helsinki,Finland;IsidoreObot,CentreforResearch
andInformationonSubstanceAbuse(CRISA),UniversityofUyo,Uyo,Nigeria;CharlesParry,
MentalHealth,Alcohol,SubstanceUseandTobaccoResearchUnit(MASTRU),SouthAfrican
MedicalResearchCouncil,CapeTown,SouthAfrica;FlavioPechansky,CenterforDrugand
AlcoholResearch,FederalUniversityofRioGrandedoSul,PortoAlegre,Brazil;AfarinRahimi-
Movaghar,IranianNationalCenterforAddictionStudies,TehranUniversityofMedicalSciences,
Tehran,IslamicRepublicofIran;JürgenRehm,CentreforAddictionandMentalHealth(CAMH),
Toronto,Canada;IngeborgRossow,NorwegianInstituteofPublicHealth,Oslo,Norway;Emanuele
Scafato,NationalCentreonAddictionsandDoping,Rome,Italy;TimStockwell,CanadianInstitute
forSubstanceUseResearch,UniversityofVictoria,Victoria,Canada;JallalToufiq,Moroccan
ObservatoryonDrugsandAddictions,RabatFacultyofMedicine,Rabat,Morocco.
Technicaladviceandinputtothedevelopmentofthereportanditskeymessageswereprovided
bytheeditorialgroupthatincludedHamadAlGhaferi,SchoolofHealthandEnvironmental
Studies,HamdanBinMohammedSmartUniversity,Dubai,UnitedArabEmirates;Sawitri
Assanangkornchai,PrinceofSongklaUniversity,Songkla,Thailand;ThomasBabor,University
ofConnecticutSchoolofMedicine,Connecticut,UnitedStatesofAmerica;ColinDrummond,
NationalAddictionCentre,InstituteofPsychiatry,PsychologyandNeuroscience,King’sCollege
vi
Acknowledgements
London,London,UnitedKingdomofGreatBritainandNorthernIreland;WeiHao,MentalHealth
Institute,CentralSouthUniversity,Changsha,China;DavidJernigan,BostonUniversitySchoolof
MentalHealth,Boston,UnitedStatesofAmerica;EvgenyKrupitsky,BekhterevNationalMedical
ResearchCentreforPsychiatryandNeurology,St.Petersburg,RussianFederation;Nazarius
MbonaTumwesigye,SchoolofPublicHealth,MakerereUniversity,Kampala,Uganda;Maria
ElenaMedina-Mora,NationalInstituteofPsychiatry,MexicoCity,Mexico;NeoMorojele,Faculty
ofHumanities,UniversityofJohannesburg,Johannesburg,SouthAfrica;JacekMoskalewicz,
InstituteofPsychiatryandNeurology,Warsaw,Poland;PratimaMurthy,NationalInstituteof
MentalHealthandNeurosciences(NIMHANS),Bangalore,India;JürgenRehm,CentreforAddiction
andMentalHealth(CAMH),Toronto,Canada;RobinRoom,LaTrobeUniversity,Melbourne,
Australia;KevinShield,CentreforAddictionandMentalHealth(CAMH),Toronto,Canada.
Preparationoftheestimatesonalcoholconsumptionandalcohol-attributablediseaseburden
includedinthereportwasacollaborativee?ortoftheADAunitintheWHODepartmentofMental
HealthandSubstanceUsewiththeCentreforAddictionandMentalHealth(CAMH),Toronto,
Canada.ParticularthanksareduetoKevinShield,JürgenRehm,AshleyWhettlauferandAri
Franklin.
AngelaMe,ChloeCharpentier,HernanEpsteinandKamranNiazofthefromResearchand
TrendAnalysisBranchandGiovannaCampelloandAnjaBussefromthePrevention,Treatment
&RehabilitationSectionoftheUnitedNationsO?iceonDrugsandCrime(UNODC)provided
technicalinputtothechapterontreatmentforsubstanceusedisorders.
ThereportwouldnothavebeenpossiblewithoutthecontributionsoftheWHOMemberStates
nationalcounterpartsforimplementationoftheGlobalstrategytoreducetheharmfuluseof
alcoholandthecountryfocalpointsnominatedforparticipationintheWHOsurveyonprogress
onSDGhealthtarget3.5whoprovidedcountry-leveldataandotherrelevantinformationon
alcoholconsumption,alcohol-relatedharm,policyresponsesandservicecapacityfortreatment
ofsubstanceusedisorders.WHOextendsitsgratitudetoallcontributorsandreviewersnot
otherwisestated.
WHOinternswhocontributedtotheprocessofdatacollectionandcompilationinclude:Sibella
Breidahl,RuchikaJain,LinmiaoJiang,AanisahKhanzadaJiang.
Finally,WHOgratefullyacknowledgesthefinancialsupportoftheNationalRehabilitationCentre
inAbuDhabi(UAE)andtheGovernmentofNorwayforthedevelopmentandproductionofthis
report.
vii
Abbreviations
15+Populationofthoseaged15yearsandolder
AAFAlcohol-attributablefraction
ABVAlcoholbyvolumeADAlcoholdependenceADH1BAlcoholdehydrogenase1B
AFRWHOAfricanRegion
AFROWHORegionalO?iceforAfrica
AIDSAcquiredimmunodeficiencysyndrome
ALDAlcoholicliverdisease
AMRWHORegionoftheAmericas
AMRO/PAHOWHORegionalO?iceforAmericas/PanAmericanHealthOrganization
APCAlcoholpercapitaconsumptionARBDAlcohol-relatedbirthdefects
ARIMAAutoregressiveintegratedmovingaverage
ARNDAlcohol-relatedneurodevelopmentaldisorder
ASDRAge-standardizeddeathrate
ASSISTAlcohol,SmokingandSubstanceInvolvementScreeningTest
AUDAlcoholusedisorder
AUDITAlcoholUseDisordersIdentificationTest
BACBloodalcoholconcentration
BMIBodymassindex
BrACBreathalcoholconcentration
CAMHCentreforAddictionandMentalHealth
CBTCognitive-behaviouraltherapy
CEACost-e?ectivenessanalysisCIConfidenceinterval
CMContingencymanagement
CVDCardiovasculardisease
DALYDisability-adjustedlifeyear
EMRWHOEasternMediterraneanRegion
viii
Abbreviations
EMROWHORegionalO?icefortheEasternMediterranean
EURWHOEuropeanRegion
EUROWHORegionalO?iceforEurope
ESPADEuropeanSchoolSurveyProjectonAlcoholandOtherDrugs
FAOFoodandAgricultureOrganizationoftheUnitedNations
FAOSTATFoodandAgricultureOrganizationoftheUnitedNations(FAO)statisticaldatabase
FASFetalalcoholsyndrome
FASDFetalalcoholspectrumdisorder
GBDGlobalburdenofdiseaseGDPGrossdomesticproduct
GENACISGender,alcohol,andculture:aninternationalstudy
GHEGlobalhealthestimatesGHOGlobalhealthobservatory
GISAHWHOglobalinformationsystemonalcoholandhealth
GNIGrossnationalincome
GSHSGlobalschool-basedstudenthealthsurveys
GSRAHGlobalstatusreportonalcoholandhealth
HAARTHighlyactiveantiretroviraltherapy
HCDHeavycontinuousdrinking
HCVHepatitisCvirus
HEDHeavyepisodicdrinking
HIVHumanimmunodeficiencyvirus
IARCInternationalAgencyforResearchonCancer
ICDInternationalClassificationofDiseases
IHMEInstituteforHealthMetricsandEvaluation
IHRInternationalHealthRegulations
INCBInternationalNarcoticsControlBoard
IWSRInternationalWineandSpiritsResearch
LMICLowandmiddle-incomecountries
MDGsMillenniumDevelopmentGoals
METMotivationalenhancementtherapy
MVAMotorvehicleaccidentsNCDNoncommunicablediseaseNGONon-governmentalorganization
ix
Globalstatusreportonalcoholandhealthandtreatmentofsubstanceusedisorders
NSPNeedleandsyringeprogramme
OIVOrganisationInternationaledelaVigneetduVin
OAMTOpioidagonistmaintenancetreatment
PAFPopulation-attributablefraction
pFASPartialfetalalcoholsyndrome
PPPPurchasingpowerparity
RBSResponsiblebeverageservice
RRRelativerisk
SACUSouthernAfricanCustomsUnion
SAMHSASubstanceAbuseandMentalHealthServicesAdministration
SCIServicecapacityindex
SDGsSustainableDevelopmentGoals
SEARWHOSouth-EastAsiaRegion
SEAROWHORegionalO?iceforSouth-EastAsia
SESSocioeconomicstatus
STDsSexuallytransmitteddiseases
STIsSexuallytransmittedinfections
STEPSSTEP-wiseapproachtosurveillance
SUDSubstanceusedisorder
TBTuberculosis
UIUncertaintyintervals
UNUnitedNations
UNODCUnitedNationsO?iceonDrugsandCrime
UNWTOWorldTourismOrganization
USDUSdollar
WHAWorldHealthAssemblyWHOWorldHealthOrganization
WIWineInstitute
WPRWHOWesternPacificRegion
WPROWHORegionalO?iceforWesternPacific
YLDYearsoflifewithdisability
YLLYearsoflifelost
x
Executivesummary
Chapter1.Psychoactivesubstanceuse,healthanddevelopment
Inviewoftheparticularpropertiesofpsychoactivesubstancesandtheirimpactonhealth
anddevelopment,mostpsychoactivesubstancesrequirespecialprovisionsforregulationof
theirproduction,distribution,marketinganduse.
Theimpactofpsychoactivesubstanceuseonhealthanddevelopmentisdeterminedby
multiplesocioeconomic,psychosocialandbiologicalfactorswhichneedtobeaddressedin
e?ectiveprevention,treatmentandharmreductionstrategiesandinterventions.
Theimpactofalcohol,tobaccoandpsychoactivedruguseonthehealthoftheworld’s
populationisunacceptablyhighbyanymetric,andfortheworkingagepopulationitexceeds
theimpactofanyotherriskfactor.
Thereisacomplexrelationshipbetweensubstanceuse,alcohol-anddrug-relatedharmsand
socioeconomicstatus,andpeoplewithlowersocioeconomicstatusaredisproportionally
a?ectedbyharmsduetosubstanceuse.
Substanceusehasasignificantimpactonmentalhealth,andsubstanceusedisorder
co-occurwithmentalhealthconditionsandworsentheirhealthoutcomes,includingall-cause
prematuremortalityaswellasmortalityduetosuicides.
Substanceusehasasignificantimpactonthedevelopmentandoutcomesofanumberof
majornoncommunicablediseases,andtheglobalimpactofpsychoactivedrugsandsubstance
usedisordersonnoncommunicablediseaseshastobefurtherexploredanddocumented.
InjectingdrugusecontinuestobeanimportantdriverofepidemicsofHIVandviralhepatitis
insomepopulations,andsubstanceuseandsubstanceusedisordersareassociatedwithan
increasedriskofacquiringinfectionsandwithnegativee?ectsontreatmentoutcomes.
Substanceuseandsubstanceusedisordersaremajorcontributorstovarioustypesofinjuries,
includingtra?ic-andviolence-relatedinjuries.Reducingthenumberofglobaldeathsdueto
injuriesrequiresimplementationofe?ectivestrategiesandinterventionstopreventinjuries
associatedwithalcoholanddruguse.
Commercialdeterminantsofsubstanceusehavetobeaddressedasapartofcomprehensive
policyresponsestoreducethenegativeimpactofpsychoactivesubstanceuseonhealthand
developmentinpopulations.
Chapter2.Alcoholconsumption,alcohol-relatedharmandpolicyresponses
Alcoholconsumption
Totalalcoholpercapitaconsumptionintheworldpopulationdecreasedslightlyfrom5.7litres
in2010to5.5litresin2019(relativereductionof4.5%)withthehighestlevelsofpercapita
consumptionin2019intheWHOEuropeanRegion(9.2litres)andtheRegionofAmericas(7.5
litres).
xi
Globalstatusreportonalcoholandhealthandtreatmentofsubstanceusedisorders
TheCOVID-19pandemichadasignificantimpactonglobalalcoholconsumption,withan
estimated10%relativereductionfrom2019to2020butwithdi?erent,andsometimes
opposite,impactsindi?erentcountriesandpopulationgroups.
In201956%oftheworld’spopulationaged15+abstainedfromdrinkingalcohol–thenumbers
ofdrinkersandabstainersintheworldarerelativelystableovertime.
Thelevelofalcoholconsumptionpercapitaamongdrinkersamountsonaverageto27grams
ofpurealcoholperday,whichisassociatedwithappreciablyincreasedrisksofnumerous
healthconditionsandassociatedmortalityanddisability.
In2019,17%ofpeopleaged15+yearsand38%ofcurrentdrinkersengagedinheavyepisodic
drinkingor“bingedrinking”(consumingatleast60gofpurealcoholononeormoreoccasions
inthelastmonth),whilecontinuousheavydrinkingwashighlyprevalent(6.7%)amongmen.
Trendsintotalalcoholpercapitaconsumption(APC)di?erbetweenWHOregionswitha
substantialdecreaseinEuropeandamarkedincreaseinAPCinSouth-EastAsiasince2000.
InallWHOregionsgenderdi?erencesinalcoholconsumptionaresignificantwithnomajor
changesovertimeglobally.
In201
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