Nitracrine-hydrochloride-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENitracrinehydrochlorideCat.No.:HY-U00279BCASNo.:6514-85-8分?式:C??H??ClN?O?分?量:360.84作?靶點(diǎn):DNA/RNASynthesis作?通路:CellCycle/DNADamage儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Nitracrinehydrochloride?種鉑類抗腫瘤藥物，具有選擇性對(duì)缺氧細(xì)胞的毒性。Nitracrinehydrochloride在缺氧條件下對(duì)中國倉?巢細(xì)胞系A(chǔ)A8展現(xiàn)出顯著的細(xì)胞毒性，其效能約為?索尼達(dá)唑的100,000倍。Nitracrinehydrochloride通過與DNA的插?結(jié)合和形成共價(jià)加合物來發(fā)揮其作?。Nitracrinehydrochloride在缺氧條件下的細(xì)胞毒性與其還原代謝形成烷化物質(zhì)有關(guān)，同時(shí)可能通過與DNA的插?增強(qiáng)對(duì)DNA的反應(yīng)性，從?提?效能。Nitracrinehydrochloride還可抑制RNA合成，有助于其抗腫瘤效果。REFERENCES[1].WilsonWR,etal.Selectivetoxicityofnitracrinetohypoxicmammaliancells.BrJCancer.1984Feb;49(2):215-23.[2].GniazdowskiM,etal.Nitracrineanditscongeners--anoverview.GenPharmacol.1995May;26(3):473-81.[3].DaghastanliNA,etal.Cytotoxicityofnitroheterocycliccompounds,quinifurylandnitracrine,towardsleukaemicandnormalcellsonthedarkandunderilluminationwithvisiblelight.JPhotochemPhotobiolB.2004Jul19;75(1-2):27-32.[4].SelectivetoxicityofnitracrinetohypoxicmammaliancellsMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-537003