Chlorpromazine-hydrochloride-Standard-生命科學試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEChlorpromazine(hydrochloride)(Standard)Cat.No.:HY-B0407ARCASNo.:69-09-0分子式:C??H??Cl?N?S分子量:355.33作用靶點:DopamineReceptor;Autophagy;CytochromeP450;5-HTReceptor作用通路:GPCR/GProtein;NeuronalSignaling;Autophagy;MetabolicEnzyme/Protease儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 Chlorpromazine(hydrochloride)(Standard)是Chlorpromazine(hydrochloride)的分析標準品。本產(chǎn)品用于研究及分析應用。Chlorpromazinehydrochloride是一種口服有效的、可透過血腦屏障的抗精神病劑，能有效拮抗D2多巴胺受體和5-HT2A，已廣泛用于精神分裂癥和其他精神疾病。Chlorpromazinehydrochloride可通過多種途徑發(fā)揮抗癌活性，IC50&Target D2dopaminereceptors;5-HT2A[1][6].REFERENCESKamgar-DayhoffP,etal.Multifacetedeffectofchlorpromazineincancer:implicationsforcancertreatment.Oncotarget.2021Jul6;12(14):1406-1426.ShinSY,etal.TheantipsychoticagentchlorpromazineinducesautophagiccelldeathbyinhibitingtheAkt/mTORpathwayinhumanU-87MGgliomacells.Carcinogenesis.2013Sep;34(9):2080-9.YangZ,etal.Cancercell-intrinsicXBP1drivesimmunosuppressivereprogrammingofintratumoralmyeloidcellsbypromotingcholesterolproduction.CellMetab.2022Nov2:S1550-4131(22)00461-2.LeeSJ,etal.Mechanismofinhibitionbychlorpromazineofthehumanpainthresholdsodiumchannel,Nav1.7.NeurosciLett.2017Feb3;639:1-7.ThomasD,etal.TheantipsychoticdrugchlorpromazineinhibitsHERGpotassiumchannels.BrJPharmacol.2003Jun;139(3):567-74.SuzukiH,etal.Comparisonoftheanti-dopamineD?andanti-serotonin5-HT(2A)activitiesofchlorpromazine,bromperidol,haloperidolandsecond-generationantipsychoticsparentcompoundsandmetabolitesthereof.JPsychopharmacol.2013Apr;27(4):396-400.McePdfHeight1/1 MasterofBioactiveMolecules—您身邊的抑制劑大師www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-