棒桿菌微生物學(xué)教學(xué)課件

1、第二篇 致病性細菌第21章棒狀桿菌屬 微生物學(xué)教研室 錢鈞department of microbiology, harbin medical university教學(xué)大綱n掌握內(nèi)容：白喉棒狀桿菌形態(tài)染色、培養(yǎng) 特性 致病物質(zhì)及所致疾病 微生物學(xué)檢查法及特異性防治原則n熟悉內(nèi)容：白喉棒狀桿菌的免疫性及錫克試驗原 理及結(jié)果判定n了解內(nèi)容：棒狀桿菌屬的分類、分布及致病性department of microbiology, harbin medical university問題n白喉棒狀桿菌的特異性預(yù)防n白喉棒狀桿菌致病物質(zhì)及所致疾病 department of microbiology, har

2、bin medical university棒狀桿菌屬n白喉棒狀桿菌（）n類白喉桿菌） 白喉棒狀桿菌department of microbiology, harbin medical university形態(tài)與染色n革蘭陽性，細長彎曲，一端或兩端膨大呈棒狀n美藍或奈瑟染色，菌體兩端或一端可見著色較深的異染顆粒department of microbiology, harbin medical university培養(yǎng)特性n需氧或兼性厭氧n呂氏培養(yǎng)基n亞碲酸鉀（k2teo23h2o）血瓊脂平板department of microbiology, harbin medical universi

3、ty變異、抵抗力n變異u形態(tài)、菌落和毒力us型變?yōu)閞型department of microbiology, harbin medical university致病物質(zhì)n白喉毒素（diphtheria toxin）n索狀因子（cord factor）nk抗原department of microbiology, harbin medical universitydepartment of microbiology, harbin medical university白喉棒狀桿菌（鼻咽腔）飛沫、污染物品鼻 咽喉氣管局部細菌和毒素的作用灰白色假膜粘膜水腫及假膜脫落，引起呼吸道阻塞，甚至窒息死亡。外

4、毒素入血毒血癥心肌肝腎上腺外周神經(jīng)內(nèi)臟出血心肌炎軟腭麻痹 聲嘶 腎上腺功能障礙2-7天潛伏期所致疾病：白喉department of microbiology, harbin medical universitydepartment of microbiology, harbin medical university免疫性n抗毒素免疫n錫克試驗（schick test）department of microbiology, harbin medical university微生物學(xué)檢查法n標本department of microbiology, harbin medical university防治原則n人工自動免疫 depart