世界最杰出的生物醫(yī)學(xué)論文

1、世界最杰出的生物醫(yī)學(xué)論文 千名生物學(xué)家（Faculty of 1000 Biology）和千名醫(yī)學(xué)家（Faculty of 1000 Medicine）是英國BioMed Central出版集團(tuán)，所建立的兩個醫(yī)學(xué)生物學(xué)論文數(shù)據(jù)庫。它是由美國哈佛大學(xué)和英國劍橋大學(xué)等近5000多名世界頂級生物醫(yī)學(xué)同行專家，所推薦和評選出的世界醫(yī)學(xué)和生物學(xué)的最新發(fā)表的論文所組成。論文依據(jù)創(chuàng)新性、新理論、新發(fā)現(xiàn)、新技術(shù)、科學(xué)價值和實(shí)際應(yīng)用前景等原則，從世界上幾千種重要的醫(yī)學(xué)生物學(xué)雜志，成千上萬篇論文中，實(shí)時進(jìn)行篩選和評定，評選出F1000因子，并進(jìn)行分級排序，分為杰出(Exceptional 9分)、必讀(Must

2、Read 6分)和推薦(Recommend 3分)三個級別，并寫有簡短的評語。再向醫(yī)學(xué)生物學(xué)界進(jìn)行推薦和發(fā)布，以提供世界上最重要、最優(yōu)秀的生物醫(yī)學(xué)論文信息和最新研究成果與發(fā)展趨勢。 F1000只重視論文的實(shí)際科學(xué)價值和臨床應(yīng)用前景，不考慮期刊的狀況和論文在何處發(fā)表，影響因子（I F）值也僅僅作為輔助參考指標(biāo)。被推薦出的論文不足SCI發(fā)表論文的千分之二，其中杰出的論文僅占所推薦論文的5%。F1000還依據(jù)不同的科學(xué)領(lǐng)域，適時評選出最近和最受關(guān)注（Must-Viewed）的10篇最佳論文，稱為“Top 10”，并不斷更新。此外還邀請世界上最知名和權(quán)威的領(lǐng)域科學(xué)家，編寫生物醫(yī)學(xué)最近的進(jìn)展、評論和綜述

3、，刊登在“F1000 Reports上”。 F1000是一個新的醫(yī)學(xué)生物學(xué)論文數(shù)據(jù)庫，是一個新的生物醫(yī)學(xué)論文評價工具，是一個新的醫(yī)學(xué)論文評估的專家系統(tǒng)。它不僅可以幫助我們來快速檢索世界上最“杰出”、“必須閱讀”和“值得推薦”的生物醫(yī)學(xué)論文；還可以了解每篇發(fā)表論文的專家評價觀點(diǎn)和意見，使我們可以節(jié)時、高效、全面認(rèn)識和了解當(dāng)今世界上生物醫(yī)學(xué)最新研究成果和發(fā)展動向，引導(dǎo)和促進(jìn)生物醫(yī)學(xué)科學(xué)的發(fā)展。研究論文能為F1000所收錄和推薦，成為F1000“杰出”論文，代表著該論文的極高的科學(xué)水平和重要的科學(xué)價值。 目前我國每年被SCI收錄的醫(yī)學(xué)生物學(xué)論文已逾萬篇，成為“論文大國”，但能為F1000收錄為“杰出

4、”的論文卻寥寥。以20092010年為例，在F1000收錄和推薦出1017篇“杰出”論文中，中國只有11篇，其中還有4篇是臺灣和香港的。從20002010年F1000共評出近5000篇“杰出”論文，中國（包括臺灣和香港）總共只有25有篇。反應(yīng)出我國現(xiàn)在醫(yī)學(xué)生物學(xué)研究“跟”多“創(chuàng)”少，重“量”不重“質(zhì)” ；一般資料性的工作多，有創(chuàng)新性、有實(shí)際應(yīng)用價值、有重要理論和應(yīng)用前景的論文少的潛在而深刻的危機(jī)。我們必須在原始創(chuàng)新和實(shí)際應(yīng)用上再上一層樓！我們要發(fā)表SCI論文，要發(fā)表高IF影響因子論文；我們更要多發(fā)表F1000“杰出”論文，發(fā)表創(chuàng)新性強(qiáng)，有重要理論價值和實(shí)際應(yīng)用前景的科學(xué)論文，這才能成為真正的科

5、技強(qiáng)國。 這里我們收集了20092010年心血管、腫瘤、細(xì)胞生物學(xué)、分子生物學(xué)、免疫學(xué)、神經(jīng)科學(xué)等領(lǐng)域F1000的“杰出”論文供大家參考，更多的F1000論文，可在F1000Biology和F1000Medicine網(wǎng)站上搜索。   Biochemistry   Bioinformatics   Biotechnology   Cancer Biology   Cardiovascular Biology   Cell Biology   Chemical

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10、over and a shaker'- 53BP1 allows DNA doublestrand breaks a chance to dance and unite cell-A virtual cycle- theory and experiment converge on the exit from mitosis cell-Aberrant mRNA transcripts and nonsense-mediated decay cell-Autophagy of intracellular microbes and mitochondria- two sides of th

11、e same coin cell-Brd4 engagement from chromatin targeting to transcriptional regulation- selective contact with acetylated histone H3 and H4 cell-Conformational changes in receptor tyrosine kinase signaling- an ErbB garden of delights cell-Destroy to create- E3 ubiquitin ligases in neurogenesis cell

12、-Doing cell biology in embryos- regulated membrane traffic and its implications for cadherin biology cell-Epigenetic regulation of antigen receptor gene rearrangement cell-G-protein-coupled receptor structure cell-Induced pluripotent stem (iPS) cells- an up-to-the-minute review cell-Inhibitor of Apo

13、ptosis (IAP) proteins as drug targets for the treatment of cancer cell-Intracellular trafficking and signaling in development cell-LOV conquers (sm)All GTPases cell-Membrane deformation and separation cell-Microtubule motors- moving forward on many fronts cell-Mitochondria and apoptosis- a quick tak

14、e on a long view cell-novel functions of the exocyst complex in polarized epithelia in animals cell-PARP inhibitors in BRCA1-BRCA2 germline mutation carriers with ovarian and breast cancer cell-Plk4-SAK-ZYG-1 in the regulation of centriole duplication cell-Putative functions of caspase-2 cell-Recent

15、 advances in polyubiquitin chain recognition cell-Recent advances in understanding Golgi biogenesis cell-Regulatory roles of the cadherin superfamily cell-Role of caspases and non-caspase proteases in cell death cell-Roles of AD-cofilin in actin polymerization and beyond cell-Roles of the small GTPa

16、ses RhoA and Rac1 in cell behavior cell-Single-molecule dynamics of nuclear mRNA cell-Spindle checkpoint silencing- ensuring rapid and concerted anaphase onset cell-Telomeric RNAs as a novel player in telomeric integrity cell-The roles, mechanisms, and controversies of autophagy in mammalian biology

17、 cell-Transport vesicle uncoating- it's later than you think cell-Understanding lipid rafts and other related membrane domains cell-Vesicle coating and uncoating- controlling the formation of large COPII-coated carriers cell-When transcription meets recombination ecology-Characterizing changes i

18、n marine ecosystem services ecology-Climate change and biodiversity conservation- impacts, adaptation strategies and future research directions ecology-Current themes and recent advances in modelling species occurrences ecology-Eco-evolutionary dynamics- intertwining ecological and evolutionary proc

19、esses in contemporary time ecology-Evaluation of global change impacts on diffuse pollution ecology-Evolutionary impacts of fishing ecology-Extinction risks from climate change- macroecological and historical insights Ecology-Modelling ecosystem services in terrestrial systems ecology-The consequenc

20、es of human-driven ocean acidification for marine life ecology-Toward understanding the effect of top predators on ecosystems genome-A direct measurement of crossing over in human prophase oocytes genome-Advances in the genetics of primary torsion dystonia genome-Applications of high-throughput sequ

21、encing to chromatin structure and function in mammals genome-Bioinformatic detection of horizontally transferred DNA in bacterial genomes genome-CRISPR-Cas- an adaptive immunity system in prokaryotes genome-Distinct disorders affecting the brain share common genetic origins genome-Emerging technolog

22、ies for the genomic analysis of cancer genome-Genetics of pulmonary arterial hypertension- do the molecular findings have translational value- genome-Hidden ribozymes in eukaryotic genome sequence genome-how medical sequencing and network biology will enable personalized medicine genome-Insulators-

23、linking genome architecture to gene regulation genome-Mapping chromatin conformation genome-Pharmacogenetics of osteoporosis genome-PRDM9 sticks its zinc fingers into recombination hotspots and between species genome-Prediction of function in protein superfamilies genome-RecA-independent single-stra

24、nded DNA oligonucleotide-mediated mutagenesis genome-Recent advances in RNA sequence analysis genome-Retrotransposons and germ cells- reproduction, death, and diversity genome-The application of massively parallel sequencing technologies genome-Ubiquitous antisense transcription in eukaryotes- novel

25、 regulatory mechanism or byproduct of opportunistic -NA polymerase genome-When transcription meets recombination- a lesson from the human RECQ protein complexes imm-Antigen processing for MHC presentation by autophagy imm-inf-A novel mucosal RORt+NKp46+ cell subset is a source of interleukin-22 imm-

26、inf-Advances in understanding the interaction between the gut microbiota and adaptive mucosal immune responses imm-inf-Alternative macrophage activation and the regulation of metabolism imm-inf-An update on pathobiologic roles of anti-glycan antibodies in Guillain-Barr茅 syndrome imm-inf-B cell-targe

27、ted therapies in autoimmunity- rationale and progress imm-inf-Bacterial surface proteins and vaccines imm-inf-Do apicomplexan parasite-encoded proteins act as both ligands and receptors during host cell invasion imm-inf-Do apicomplexan parasites hijack the host cell microRNA pathway for their intrac

28、ellular development imm-inf-Duality in the Th17-Treg developmental decision imm-inf-Electron transport chains of lactic acid bacteria - walking on crutches is part of their lifestyle imm-inf-Genetic reprogramming of host cells by bacterial pathogens imm-inf-Gut commensal flora- tolerance and homeost

29、asis imm-inf-HIV vaccination- turning the spotlight on effector memory T cells as mucosal gatekeepers imm-inf-HIV-1 host interactions- integration of large-scale datasets imm-inf-Latest advances in innate antiviral defence imm-inf-Lessons from the failure of the adenovector HIV vaccine imm-inf-New t

30、emplates for HIV-1 antibody-based vaccine design imm-inf-Ocular immune privilege imm-inf-Recent insights into fatty acid acquisition and metabolism in malarial parasites imm-inf-Recent strategies to identify broadly neutralizing antibodies against influenza A virus imm-inf-Regulation of the IgE resp

31、onse imm-inf-The garden of antimicrobial delights imm-inf-The inflammasome and alum-mediated adjuvanticity imm-inf-The role of microbial polysaccharides in host-pathogen interaction imm-inf-Thymic egress- S1P of 1000 imm-inf-Two mechanisms that account for major histocompatibility complex restrictio

32、n of T cells imm-inf-Why is Pseudomonas aeruginosa a pathogen imm-The role of IL-23 in the immunopathogenesis of psoriasis ns-A current view of Alzheimer's disease ns-An uncorrelated state for the cortex ns-channelopathies- new antibody-mediated disorders of the central nervous system ns-Control

33、 of Schwann cell myelination ns-De novo prions ns-Development of object recognition in humans ns-Dysfunction of the CaV2.1 calcium channel in cerebellar ataxias ns-E3 ubiquitin ligases in neurogenesis ns-mechanotransduction in inner-ear hair cells ns-Multiple functions of dopamine neurons ns-Music d

34、rives brain plasticity ns-Neuronal calcium sensor proteins ns-Recent advances in neural development ns-Seeing with the mind's eye ns-Setting the absolute threshold of vision ns-Sources of the spatial code within the hippocampus ns-The growth cone- an integrator of unique cues into refined axon g

35、uidance ns-The posterior parietal cortex and non-spatial cognition ns-Transcranial magnetic stimulation studies of visuospatial attentional control ns-What drives corticospinal output ns-Why do oligodendrocyte lineage cells express glutamate receptors physiol-'Functional' body composition- d

36、ifferentiating between benign and non-benign obesity physiol-Biased agonism physiol-Bitopic ligands- all-in-one orthosteric and allosteric physiol-Central control of feeding physiol-Depression and metabolism- linking changes in leptin and ghrelin to mood physiol-Malarial parasite pathogenesis and dr

37、ug targets physiol-Multiple functions of dopamine neurons physiol-New antibiotics for antibiotic-resistant bacteria physiol-pharmacol-The pathophysiology of diastolic heart failure physiol-Purinergic cotransmission physiol-Regulation of the mTOR signaling pathway physiol-Role of neuropeptides, hormo

38、nes, and growth factors in regulating thymopoiesis in middle to old age physiol-Stress and eating behaviour physiol-Targeting cytokines in inflammatory diseases physiol-The ABCB1 transporter gene and antidepressant response physiol-The evolving story of orexin biology- the hits keep coming physiol-T

39、RPV4 as a target for bladder overactivity physiol-Using the ribosome to synthesize peptidomimetics structural biology-Biased agonism structural biology-Describing protein conformational ensembles structural biology-Detailed mechanism for transposition by TnpA transposase involves DNA -shape rather t

40、han direct protein-DNA recognition to generate an active nucleoprotein complex structural biology-Diversity of protein structures and difficulties in fold recognition-the curious case of protein G structural biology-Implications of the RecA structure structural biology-Mechanistic and functional ver

41、satility of radical SAM enzymes structural biology-Membrane deformation and separation structural biology-Molecular dynamics-based approaches for enhanced sampling of long-time, large-scale conformational changes in biomolecules structural biology-Monte Carlo, harmonic approximation, and coarse-grai

42、ning approaches for enhanced sampling of biomolecular structure structural biology-Nuclear magnetic resonance captures the elusive structural biology-Osmolyte solutions and protein folding structural biology-protein conformation and the ubiquitination reaction cascade structural biology-Recent advan

43、ces in polyubiquitin chain recognition structural biology-RNA pseudoknots-folding and finding structural biology-Structure of spliceosomal ribonucleoproteins structural biology-The unforeseeable hammerhead ribozyme structural biology-Understanding lipid rafts and other related membrane domains struc

44、tural biology-Unnatural amino acids- better than the real things F1000 Top 10bi-A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury bi-Cell line misidentification- the beginning of the end bi-Chaperonin-dependent accelerated substitution rates in prokaryotes b

45、i-Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model bi-Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis bi-High-resolution analysis of parent-of-origin allelic expression in the mouse brain bi-Long-timescale molecular-dyna

46、mics simulations of the major urinary protein provide atomistic interpretations of the unusual thermodynamics of ligand binding bi-Mammalian microRNAs predominantly act to decrease target mRNA levels bi-Robust Growth of Escherichia coli bi-Sex-specific parent-of-origin allelic expression in the mous

47、e brain bi-Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopy bi-The genetic landscape of a cell biochem-Functional modules and structural basis of conformational coupling in mitochondrial complex I biochem-In Vivo Double and Triple La

48、beling of Proteins Using Synthetic Amino Acids biochem-One SNARE complex is sufficient for membrane fusion biochem-Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy biochem-Robust Growth of Escherichia coli biochem-Self-confirming AND logic nanoparticles for fault-free MRI

49、 biochem-Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopy biochem-Structure of RCC1 chromatin factor bound to the nucleosome core particle biochem-Structure of the torque ring of the flagellar motor and the molecular basis for rotati

50、onal switching biochem-The architecture of respiratory complex I biochem-The functional capacity of the natural amino acids for molecular recognition biochem-Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans biology-Activation of beta-catenin in dendritic cells regulates immu

51、nity versus tolerance in the intestine biology-An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis biology-Astrocytes control breathing through pH-dependent release of ATP biology-Chaperonin-dependent accelerated substitution rates in prokaryotes biology-C

52、rucial role for human Toll-like receptor 4 in the development of contact allergy to nickel biology-Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension biology-MiR-33 contributes to the regulation of cholesterol homeostasis biology-Neuroscience and

53、the correct level of explanation for understanding mind biology-Role of secondary sensory cortices in emotional memory storage and retrieval in rats biology-Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer biology-TGF-beta signaling specifies axons during brain development biology

54、-The Amphimedon queenslandica genome and the evolution of animal complexity biology-The coevolution of human hands and feet biotech-Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5 biotech-Exploiting the determinants of stochastic gene expression in Saccharomyces cerev

55、isiae for genome-wide prediction of expression noise biotech-Fragment-based drug discovery applied to hsp90. Discovery of two lead series with high ligand efficiency biotech-Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis biotech-Metabolomic and transcriptomic stres

56、s response of Escherichia coli biotech-Sex-specific parent-of-origin allelic expression in the mouse brain biotech-Small-molecule inducers of insulin expression in pancreatic alpha-cells biotech-Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR sp

57、ectroscopy biotech-The genetic landscape of a cell biotech-Type IIA topoisomerase inhibition by a new class of antibacterial agents ca-A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution ca-Allogeneic hematopoietic cell transplantation for hem

58、atological malignancy ca-An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein ca-Cdc14- a highly conserved family of phosphatases with non-conserved functions ca-Early palliative care for patients with metastatic non鈥搒mall-cell lung cancer ca-Efficacy o

59、f azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes- a randomised, open-label, phase III study ca-Fusion gene-negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma ca-Hematopoiesis in three dimensions- human and murine bone marrow architecture visualized by confocal microscopy ca-Histone H3 Thr-3 Phosphorylation by Haspin