重組人干擾素-α2b作用機(jī)制 - Medchemexpress - MCE中國(guó)

1、Product Data SheetRecombinant Human Interferon-alpha2bCat. No.: HY-P7023Synonyms: rHuIFN-2b; IFNA; INFA2; IFN-a 2bSpecies: HumanSource: E. coliAccession: P01563Gene ID: 3440Molecular Weight: Approximately 19.2 kDaPROPERTIESAA SequenceC D L P Q T H S L G S R R T L M L L A Q M R R I S L F S C L K D R

2、H D F G F P Q E E F G N Q F Q K A E T I P V L H E M I Q Q I F N L F S T K D S S A AWD E T L L D K F Y T E L Y Q Q L N D L E A C V I Q G V G V T E T P L M K E D S I L A V R K Y F Q R I T L Y L K E K K Y S P C AW E V V R A E I M R S F S L S T N L Q E S L R S K EBiological Activity The ED50 is 2.0 107

3、units/mg.Appearance Lyophilized powder.Formulation Lyophilized after extensive dialysis against PBS.Endotoxin Level 0.2 EU/g, determined by LAL method.Reconsititution Reconstitute the lyophilized recombinant Human Interferon-alpha2b (rHuIFN-2b) to 100 g/mL using ddH2O.Storage & Stability Lyophilized

4、 recombinant Human Interferon-alpha2b (rHuIFN-2b) is stored at -20C. After reconstitution, it is stableat 4C for 2 weeks or -20C for longer. It is recommended to freeze aliquots at -20C or -80C for extended storage.Shipping Room temperature in continental US; may vary elsewhere.DESCRIPTIONBackground

5、 Human Interferon- is a cytokine belonging to the type I Interferons (IFNs), acts as a regulatory mediator of theimmune response, and also shows antiviral, antitumor activity. IFNs are used in treatment of hepatitis B and C and inantitumor therapy1. Human Interferon-2 can also be used to treat hairy

6、 cell leukemia, chronic myelogenousleukemia, malignant melanoma, follicular lymphoma, condylomata acuminata, and AIDS-related Kaposi sarcoma2.Page 1 of 2 www.MedChemEREFERENCES1. Gerasymenko IM, et al. MULTIPLEX PCR ASSAY FOR DETECTION OF HUMAN SOMATOTROPIN AND INTERFERON ALPHA2b GENES IN PLANT MATE

7、RIAL.Tsitol Genet. 2015 May-Jun;49(3):3-8.2. Chang CH, et al. A new method to produce monoPEGylated dimeric cytokines shown with human interferon-2b. Bioconjug Chem. 2009 Oct21;20(10):1899-907.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-379